Patents by Inventor Thomas Patrick MARKOTAN

Thomas Patrick MARKOTAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL COMPOSITIONS COMPRISING MACROLIDE DIASTEREOMERS, METHODS OF THEIR SYNTHESIS AND THERAPEUTIC USES
    Publication number: 20230321109
    Abstract: The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell proliferation compared to the corresponding compositions comprising mixture of diastereomers. The disclosure further provides drug-ligand conjugates formed using diastereomer of the macrolide. The disclosure also provides novel method of preparation of diastereomer of the macrolide and their therapeutic uses.
    Type: Application
    Filed: December 22, 2022
    Publication date: October 12, 2023
    Inventors: Thomas NITTOLI, Nareshkumar F. JAIN, Thomas Patrick MARKOTAN
  • Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses
    Patent number: 11596635
    Abstract: The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell proliferation compared to the corresponding compositions comprising mixture of diastereomers. The disclosure further provides drug-ligand conjugates formed using diastereomer of the macrolide. The disclosure also provides novel method of preparation of diastereomer of the macrolide and their therapeutic uses.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: March 7, 2023
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventors: Thomas Nittoli, Nareshkumar F. Jain, Thomas Patrick Markotan
  • PHARMACEUTICAL COMPOSITIONS COMPRISING MACROLIDE DIASTEREOMERS, METHODS OF THEIR SYNTHESIS AND THERAPEUTIC USES
    Publication number: 20190151323
    Abstract: The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell proliferation compared to the corresponding compositions comprising mixture of diastereomers. The disclosure further provides drug-ligand conjugates formed using diastereomer of the macrolide. The disclosure also provides novel method of preparation of diastereomer of the macrolide and their therapeutic uses.
    Type: Application
    Filed: November 13, 2018
    Publication date: May 23, 2019
    Inventors: Thomas NITTOLI, Nareshkumar F. JAIN, Thomas Patrick MARKOTAN
  • PHARMACEUTICAL COMPOSITIONS COMPRISING MACROLIDE DIASTEREOMERS, METHODS OF THEIR SYNTHESIS AND THERAPEUTIC USES
    Publication number: 20160354482
    Abstract: The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell proliferation compared to the corresponding compositions comprising mixture of diastereomers. The disclosure further provides drug-ligand conjugates formed using diastereomer of the macrolide. The disclosure also provides novel method of preparation of diastereomer of the macrolide and their therapeutic uses.
    Type: Application
    Filed: August 26, 2014
    Publication date: December 8, 2016
    Inventors: Thomas NITTOLI, Nareshkumar F. JAIN, Thomas Patrick MARKOTAN