Abstract: The present disclosure includes MGMT modifications that cause MGMT resistance to MGMT inhibitors. The present disclosure also includes in vivo, in vitro, and ex vivo modification of MGMT-encoding nucleic acids to encode and express an MGMT variant that is resistant to MGMT inhibitors. Inhibitor-resistant MGMT modifications and modification of an MGMT-encoding nucleic can occur or be used in conjunction with a therapeutic modification, e.g., in a single cell. Expression of inhibitor-resistant MGMT can selectively protect modified cells from a selection regimen, such as a selection regimen including an MGMT inhibitor and an alkylating agent. Accordingly, in vivo, in vitro, and ex vivo modification of MGMT-encoding nucleic acids can be used in gene therapy to select for modified cells.

Abstract: Systems and methods are disclosed for automatically extracting keys and corresponding values in any type of source document. Extracting desired words from the tokens in any type of document is based on a uniform approach to represent the source document. This uniform representation encodes features of the desired tokens along with the neighborhood information so that values associated with a given key can be extracted. The disclosed technique learns the representation of tokens independent of source document type and the learned representation is then used to determine relationships between multiple tokens. The neighborhood information and position information are used to determine various relationships between keys and values.

Abstract: A display system having a dynamic display and a lighting system. The lighting system includes a first light source for generating a first light within a first optical spectrum, a second light source for generating a second light within a second optical spectrum, a first sensor activated when detecting light within the first optical spectrum, and a second sensor activated when detecting light within the second optical spectrum. The lighting system further includes a controller that selectively activates one or more of the first light source and the second light source based on a combination of the first sensor and the second sensor activated. The lighting system also includes a light redistribution element that receives the first light and the second light and directs the first light and the second light toward the display. A showing of the designated information is not disrupted by the second light.

Abstract: A method for calibrating a 3D printer includes the steps of providing information obtained in a factory calibration indicating a center of an inner diameter of a tip orifice in a metal extrusion nozzle and a center of a tip surface for the nozzle and inductively sensing the nozzle with an eddy current sensor when secured to a print head on a gantry or robotic arm of the 3D printer to identify a sensed location of the center of the tip surface of the nozzle. The method includes determining a location of the center of the inner diameter of the tip orifice on the nozzle on the print head and utilizing the provided information to locate the center of the inner diameter of the tip orifice.

Abstract: A method for growing leaf vegetables and/or herbs and/or potato plants, a device there for, a system there for, and use of ferrate for growing leaf vegetables and/or herbs and/or potato plants. The method includes providing a growth substrate, providing one or more leaf vegetable and/or herb and/or potato plant seeds and/or leaf vegetable plants and/or herb plants and/or potato plants to a growth substrate, providing growth media to the one or more leaf vegetable seeds and/or herb seeds and/or potato plant seeds and/or leaf vegetable plants and/or herb plants and/or potato plants, wherein the growth media at least comprises a liquid, and providing ferrate to the growth media.

Abstract: This disclosure describes visual interfaces as well as underlying methods and systems for bringing generative customer experience automation to the enterprises and their end-users. A visual workflow builder is part of a micro-engagement system that allows for creation of workflows without writing any code. The micro-engagement platform is enhanced to support an environment where the content of the micro-engagement can be generated, presented and selected by an enterprise persona and launched to the end-users. The generated content is more dialog-friendly and is based on a set of parameters around specific workflows and prior practices as learned by Large Language Models or other relatively smaller but more domain-specific fine-tuned language models. End-users can also input their descriptions through which apt workflows can be dynamically generated at runtime, thereby personalizing the end-user's engagement experience further.

Abstract: Systems and methods are disclosed for automatically extracting keys and corresponding values in any type of source document. Extracting desired words from the tokens in any type of document is based on a uniform approach to represent the source document. This uniform representation encodes features of the desired tokens along with the neighborhood information so that values associated with a given key can be extracted. The disclosed technique learns the representation of tokens independent of source document type and the learned representation is then used to determine relationships between multiple tokens. The neighborhood information and position information are used to determine various relationships between keys and values.

Abstract: Systems and methods are disclosed for automatically extracting relevant information from various source document that include tabular data. The tabular data in various forms can be received as mixed with other dissimilar data. Tabular data can appear in different orientations, document types, and can be fragmented horizontally or vertically. The proposed technique automatically detects table header data in certain regions of the received source document and associates values to the extracted headers. The proposed system is capable of combining different snippets of smaller tables into a single cohesive and monolithic table with headers designated by a set of keywords and all the values in the various columns (and/or rows) included under or along proper headers.

Abstract: A method for calibrating a 3D printer includes the steps of providing information obtained in a factory calibration indicating a center of an inner diameter of a tip orifice in a metal extrusion nozzle and a center of a tip surface for the nozzle and inductively sensing the nozzle with an eddy current sensor when secured to a print head on a gantry or robotic arm of the 3D printer to identify a sensed location of the center of the tip surface of the nozzle. The method includes determining a location of the center of the inner diameter of the tip orifice on the nozzle on the print head and utilizing the provided information to locate the center of the inner diameter of the tip orifice.

Abstract: A drug delivery device includes a housing having proximal and distal ends and a longitudinal axis extending therebetween, an injection assembly at least partially disposed within the housing at or near the proximal end, a shield slidably coupled with the housing, a drive assembly operably coupled with the injection assembly and the shield, and a cap. The injection assembly includes a needle or a cannula. The shield is positionable in an extended position in which at least a proximal end thereof extends a distance beyond the proximal end of the housing. The drive assembly is engageable to deliver a medicament via the injection assembly. The cap is removably coupled with at least one of the shield or the housing and is adapted to limit movement of the shield when coupled with the shield and/or the housing such that the drive assembly is restricted from delivering the medicament via the injection assembly.

Abstract: A digital license plate includes a display system capable of showing a license number readable by camera systems even under poor external lighting conditions. A light redistribution element is positioned near the display system and a lighting system is positioned to direct light from the light redistribution element and toward the display system. In some embodiments the lighting system includes a narrowband lighting element such as can be provided by a narrowband light source, and the display system includes an electrophoretic or LCD display.

Abstract: The invention relates to a pharmaceutical composition of 8-chloro-5-methyl-1-1-[4-(2-pyridyloxy)cyclohexyl]-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, a process for the preparation thereof and its use in the treatment of diseases. The pharmaceutical composition includes a tablet kernel consisting of a disintegrant, a filler, a glidant and a lubricant.

Abstract: A drug delivery device includes a housing having proximal and distal ends and a longitudinal axis extending therebetween, an injection assembly at least partially disposed within the housing including a needle or a cannula, a drive assembly operably coupled with the injection assembly, a shield slidably coupled with the housing and operably coupled with the drive assembly, and a retention mechanism. The drive assembly is engageable to deliver a medicament via the injection assembly. The shield is positionable in an extended position in which at least a proximal end extends a distance beyond the proximal end of the housing and a retracted position where the proximal end of the housing protrudes a distance beyond the proximal end of the shield. Moving the shield to the retracted position engages the drive assembly to deliver the medicament via the injection assembly.

Abstract: Compounds, compositions and method of using these compounds are disclosed for treating a disease or disorder in which it is desirable to inhibit BAX, such as a cardiovascular disease or disorder.

Abstract: The invention relates to a stable, peroxide-free pharmaceutical composition of 8-chloro-5-methyl-1-[4-(2-pyridyloxy)cyclohexyl]-4,6-dihydro-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, and a process for the preparation thereof and its use in the treatment of diseases or conditions in which V1a inhibition plays a role or is implicated, such as autism spectrum disorder (ASD), and the core social and communication deficits of patients associated therewith. The formulation includes a compressed tablet kernel comprising: (a) compound of formula I, disintegrant, filler, glidant and lubricant; and (b) a film coating system comprising coating agent, colorant, plasticizer, anti-tacking agent, and coating vehicle. The process for making the formulation comprises combining the tablet kernel ingredients into a blend, sieving the blend, and compressing the blend to form a tablet kernel, and spraying the film coating system onto the tablet kernels.

Abstract: A nuclear radiation detector is disclosed. The detector includes a housing including therein: a scintillator; and a multi-pixel optical sensor positioned, relative to the scintillator, to receive photons emitted by the scintillator in response to interactions with nuclear radiation. The housing isolates the scintillator and the multi-pixel optical sensor from external light. The detector includes one or more processors operably connectable to the multi-pixel optical sensor; and one or more data stores coupled to the processors having instructions stored thereon which cause the processors to perform operations.

Abstract: Systems and techniques are provided for performing wireless communications. In some aspects, calibration of a station (STA) in a wireless communication network can be managed based on receiving a beacon frame that includes a Restricted Access Window (RAW) Parameter Set (RPS) Information Element (IE), and determining that an Association Identity (AID) indicated in the RPS IE of the received beacon frame matches a calibration AID associated with the STA. A process can further include determining a RAW based on the RPS IE and scheduling a RAW clear medium calibration (RAW-cmc) event within the RAW, based at least in part on the determination that the AID indicated in the RPS IE matches the calibration AID. Subsequently, the scheduled RAW-cmc event within the RAW can be used to perform calibration for the STA as scheduled.

Abstract: Data including current locations of candidate clouds to be seeded is obtained; based on same, a vehicle is caused to move proximate at least one of the candidate clouds to be seeded. Weather and cloud system data are obtained from a sensor suite associated with the vehicle, while the vehicle and sensor suite are proximate the at least one of the candidate clouds to be seeded. Vehicle position parameters are obtained from the sensor suite associated with the vehicle. Based on the weather and cloud system data and the vehicle position parameters, it is determined, via a machine learning process, which of the candidate clouds should be seeded, and, within those of the candidate clouds which should be seeded, where to disperse an appropriate seeding material. The vehicle is controlled to carry out the seeding on the candidate clouds to be seeded, in accordance with the determining step.

Abstract: A manhole lock system includes a frame positioned over an access opening, a cover movable between a closed position in which the cover extends over the access opening, and an open position in which the access opening is exposed; and a lock mechanism for locking the cover in the closed position. The lock mechanism includes a lock member that is movable along a path between a unlocked position and a locked position, wherein in the locked position the lock member prevents the cover from moving to the open position, wherein in the unlocked position the lock member is retracted to enable movement of the cover to the open position.