Abstract: The present invention relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g. fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains e.g. human immunoglobulin (antibody) single variable domains, and also single variable domains derived from non-human sources such as a llama or camel, e.g. a VHH including a nanobody TM (described in e.g. WO 94/04678 and WO 95/04079 inter alia). The invention further relates to uses, formulations, compositions comprising such modified C terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these molecules.

Abstract: The present disclosure includes MGMT modifications that cause MGMT resistance to MGMT inhibitors. The present disclosure also includes in vivo, in vitro, and ex vivo modification of MGMT-encoding nucleic acids to encode and express an MGMT variant that is resistant to MGMT inhibitors. Inhibitor-resistant MGMT modifications and modification of an MGMT-encoding nucleic can occur or be used in conjunction with a therapeutic modification, e.g., in a single cell. Expression of inhibitor-resistant MGMT can selectively protect modified cells from a selection regimen, such as a selection regimen including an MGMT inhibitor and an alkylating agent. Accordingly, in vivo, in vitro, and ex vivo modification of MGMT-encoding nucleic acids can be used in gene therapy to select for modified cells.

Abstract: Methods, apparatus, systems, and articles of manufacture to extend brake life cycle are disclosed herein. An example vehicle disclosed herein includes a first brake associated with a first wheel of the vehicle, a second brake associated with a second wheel of the vehicle, memory, a brake controller to execute instructions to detect a parking event, compare a temperature of at least one of the first brake or the second brake to a temperature threshold, in response to determining the temperature satisfies the temperature threshold engage the first brake for a first duration, disengage the first brake after the first duration, and engage the second brake for a second duration.

Abstract: In a method for chromium upgrading of interconnects made of ferritic steel to be used in solid oxide cell stacks, comprising the steps of shaping the interconnect, depositing a coating comprising Cr on at least one surface of the shaped interconnect and performing one or more thermal treatments at a temperature below 1000° C., the resulting Cr concentration near the surface of the interconnect is higher than the Cr concentration in the ferritic steel before shaping. Specifically, the average Cr concentration of the shaped interconnect is increased to 26 wt % Cr or higher.

Abstract: Systems and methods are disclosed for automatically extracting keys and corresponding values in any type of source document. Extracting desired words from the tokens in any type of document is based on a uniform approach to represent the source document. This uniform representation encodes features of the desired tokens along with the neighborhood information so that values associated with a given key can be extracted. The disclosed technique learns the representation of tokens independent of source document type and the learned representation is then used to determine relationships between multiple tokens. The neighborhood information and position information are used to determine various relationships between keys and values.

Abstract: A SOC stack has interconnects with a maximum distance between the contact points which are designed to compensate for pressure difference between one side of the interconnect to the other side.

Abstract: There is provided a method of measuring liquid volume in a sealed container of a breast pump of known volume comprising liquid and gas. The method includes a measurement phase, measuring the volume of gas in the container by changing a first parameter of the gas by a known amount. The method also includes measuring a change in a second parameter of the gas; calculating the volume of gas in the container using the measured change and a predetermined operation equation; and determining the volume of liquid in the container based on the calculation.

Abstract: A sensor assembly includes a body having a first end, a second end, and a longitudinal axis extending between the first and second ends, wherein at least part of the body is tubular and defines a cavity that extends along the longitudinal axis to facilitate delivery of medication therethrough, and a plurality of electrodes formed on a surface of the body, wherein each of the electrodes extends at least partially longitudinally along the body, with an electrical contact closer to the first end and a sensing region closer to the second end.

Abstract: There is disclosed a method of forming chlorine dioxide comprising passing chlorous acid through a membrane including a catalyst suitable to catalyse the formation of chlorine dioxide from chlorous acid. There is also disclosed a membrane suitable for forming an aqueous solution of chlorine dioxide comprising a catalyst suitable to catalyse the formation of chlorine dioxide from chlorous acid or alkali metal chlorite.

Abstract: The present invention relates to an electroluminescent device comprising a compound of formula (I) and a compound of formula (II), and a display device comprising the organic electroluminescent device.

Abstract: A cylinder head for an internal combustion engine with a combustion chamber, including a base body with a combustion chamber wall for closing off the combustion chamber of the internal combustion engine, the base body having a hole which penetrates the combustion chamber wall with a first opening and includes a contact section with a tapered inner contact surface; and a sealing sleeve which has a sealing section with a tapered outer sealing surface, wherein the sealing sleeve and the base body are clamped together in such a way that the contact surface and the sealing surface are in sealing contact, and wherein at least one of the contact section and the sealing section is at least partially plastically deformed.

Abstract: The present invention relates to an apparatus for determining agricultural relevant information in an agricultural environment. It is described to provide a processing unit with at least one image of an agricultural area. The at least one image corresponds with at least one area of the agricultural area. The at least one image comprises remotely acquired reflectance intensity data relating to a plurality of features on the ground. An image of the at least one image is of a first area of the agricultural environment. The processing unit is provided with at least one sensor data relating to the first area of the agricultural environment. The processing unit implements a radiation propagation model of the atmosphere that utilizes at least one model parameter. The processing unit determines modified at least one model parameter. The processing unit determines at least one agricultural relevant information for an examination area of the at least one area.

Abstract: The invention is directed to a tire comprising an innerliner including a recess with a depth within a range of 20 ?m to 3000 ?m and a stepped sidewall, wherein at least one step of the recess' sidewall includes a height within a range of 5 ?m to 1500 ?m. Furthermore, the invention is directed to a method of processing a tire including an inner surface, wherein the method comprises creating a stepped recess in an area of the inner surface by removing a first thickness of elastomer composition in a first subarea, removing a second thickness of elastomer composition in a second subarea, wherein the second subarea at least partially overlaps with the first subarea so that a third thickness of elastomer composition is removed in an overlapping zone of the first subarea and the second subarea.

Abstract: A display system having a dynamic display and a lighting system. The lighting system includes a first light source for generating a first light within a first optical spectrum, a second light source for generating a second light within a second optical spectrum, a first sensor activated when detecting light within the first optical spectrum, and a second sensor activated when detecting light within the second optical spectrum. The lighting system further includes a controller that selectively activates one or more of the first light source and the second light source based on a combination of the first sensor and the second sensor activated. The lighting system also includes a light redistribution element that receives the first light and the second light and directs the first light and the second light toward the display. A showing of the designated information is not disrupted by the second light.

Abstract: In one aspect, the invention is directed to a tire including an inner surface comprising an elastomer composition and partially enclosing a tire cavity. The tire further comprises a component including an attachment surface comprising a polymer composition, which is attached to a portion of the inner surface via an adhesive, wherein the attachment surface comprises a surface pattern comprising elevations including a height within a range of 20 ?m to 1000 ?m. In a second aspect, the invention is directed to a method of attaching a component to a portion of an inner surface of a tire. Furthermore, the invention is directed to a sensor container assembly comprising a sensor container and a tire pressure sensor.

Abstract: A silicon carbide device includes: a transistor cell having a stripe-shaped trench gate structure extending from a first surface into a silicon carbide body, the gate structure having a gate length along a lateral first direction, a bottom surface and a first gate sidewall of the gate structure being connected via a first bottom edge of the gate structure; at least one source region of a first conductivity type in contact with the first gate sidewall; and a shielding region of a second conductivity type in contact with the first bottom edge of the gate structure across at least 20% of the gate length. No source regions of the first conductivity type are in contact with a second gate sidewall of the gate structure.

Abstract: The invention relates inter alia to a device for filling a container. The device comprises a filling valve for discharging a filling material into the container. The device further comprises a throttle valve for adjusting a flow rate of the filling material. The throttle valve comprises a valve member for adjusting a flow cross-section. The throttle valve has a pneumatic drive that is operatively connected to the valve member for moving the valve member, and an electric drive that is operatively connected to the valve member for moving the valve member. Advantageously, the device can combine the advantages of a pneumatic throttle control and the advantages of an electric throttle control.

Abstract: A device for producing a 3D-printed active substance-releasing system with active substance depots, such that a radiation source in operation causes a polymerisation of a layer of the base material on the construction platform and that an inkjet printhead incorporates an active substance mixture, which has at least one active substance, into the base material in a locationally selective manner. A trough is provided, in which a base material and a construction platform are arranged, and polymerising selected regions of a layer of the base material on the construction platform and introducing, by means of an inkjet printing method, an active substance mixture, which has at least one active substance, into the base material and/or polymerised base material in a locationally selective manner in order to thereby create active ingredient depots in the active ingredient-releasing system.

Abstract: A position sensor, wherein the position sensor detects the movement of a target relative to a sine receiver coil and a cosine receiver coil and generates a corresponding sine signal and a corresponding cosine signal, and a method for error detection of a position sensor.