Patents by Inventor Thomas Philip WYCHE

Thomas Philip WYCHE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A HOST-MICROBE CO-CULTURE PERFUSION BIOREACTOR FOR DISCOVERY OF SECRETED PRODUCTS AND NOVEL INTERACTIONS AT THE HUMAN-MICROBIOTA INTERFACE
    Publication number: 20230008576
    Abstract: The present invention relates to a perfusion bioreactor for co-culturing, wherein the bioreactor grows cells in two separate environments and enables communication across environments and populations. The chambers' contents are continuously mixed to expose the environment (or cell population) of each chamber to the secreted products of the other chamber. The said bioreactor comprises at least, but not limited to, two chambers, with separate cell populations with at least two separate environments independently selected from aerobic or anaerobic environment and media favorable to cell growth. The bioreactor allows for multiple samples to be collected during an experiment to enable various analytical techniques and results. Additionally, the bioreactor comprises a multi-chamber cell culture system capable of emulating the gastro-intestinal tract.
    Type: Application
    Filed: November 20, 2020
    Publication date: January 12, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Stephen H. Kasper, Erik C. Hett, Jason Cassaday, Kumael Jafri, Thomas Philip Wyche
  • Ecteinamycin, compositions and uses thereof
    Patent number: 10660874
    Abstract: An isolated or synthesized compound of Formula I and salts thereof are provided. A compound isolated from Actinomadura and having a chemical formula of C38H60O12 is also provided. Compositions including the compounds and methods of using the compounds to treat bacterial infections including gram positive infections such as C. difficile are also disclosed.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: May 26, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Timothy Scott Bugni, Thomas Philip Wyche, Douglas R. Braun, Jeffrey S. Piotrowski, Nasia Safdar
  • ECTEINAMYCIN, COMPOSITIONS AND USES THEREOF
    Publication number: 20170348278
    Abstract: An isolated or synthesized compound of Formula I and salts thereof are provided. A compound isolated from Actinomadura and having a chemical formula of C38H60O12 is also provided. Compositions including the compounds and methods of using the compounds to treat bacterial infections including gram positive infections such as C. difficile are also disclosed.
    Type: Application
    Filed: October 28, 2015
    Publication date: December 7, 2017
    Inventors: Timothy Scott BUGNI, Thomas Philip WYCHE, Douglas R. BRAUN, Jeffrey S. PIOTROWSKI, Nasia SAFDAR