Abstract: A hygienic cover, hygienic kit, and a method thereof for a hygienic seat location including a stretchable antimicrobial hygienic headrest cover having an ability to conform itself to dimensions of the existing headrest. The cover comprises a stretchable, antimicrobial, a non-mesh fabric configured to provide a barrier between a user and the headrest. The headrest has an elastic opening in the back surface allowing the fabric to stretchily fit over an existing headrest. A tray table cover defined by a top panel, a bottom panel, and a sidewall connecting said top and bottom panels thereby creating an opening to a cavity therein is included. A pre-packaged sanitizing wipe is included to sanitize the seating location, and a container is included to encapsulate the pre-packaged sanitizing wipe, the tray table cover, and the stretchable headrest cover, wherein the headrest cover and the tray table cover are compressed.

Abstract: The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds ad compositions of the invention.

Abstract: A hygienic cover, hygienic kit, and a method thereof for a hygienic seat location including a stretchable antimicrobial hygienic headrest cover having an ability to conform itself to dimensions of the existing headrest. The cover comprises a stretchable, antimicrobial, a non-mesh fabric configured to provide a barrier between a user and the headrest. The headrest has an elastic opening in the back surface allowing the fabric to stretchily fit over an existing headrest. A tray table cover defined by a top panel, a bottom panel, and a sidewall connecting said top and bottom panels thereby creating an opening to a cavity therein is included. A pre-packaged sanitizing wipe is included to sanitize the seating location, and a container is included to encapsulate the pre-packaged sanitizing wipe, the tray table cover, and the stretchable headrest cover, wherein the headrest cover and the tray table cover are compressed.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

Abstract: A hygienic kit and a method thereof for a hygienic seat location including a stretchable antimicrobial hygienic headrest cover having an ability to conform itself to dimensions of the existing headrest. The cover comprises a stretchable, antimicrobial, a non-mesh fabric configured to provide an impenetrable barrier between a user and the headrest. The headrest has an elastic opening in the back surface allowing the fabric to stretchily fit over an existing headrest. A tray table cover defined by a top panel, a bottom panel, and a sidewall connecting said top and bottom panels thereby creating an opening to a cavity therein is included. A pre-packaged sanitizing wipe is included to sanitize the seating location, and a container is included to encapsulate the pre-packaged sanitizing wipe, the tray table cover, and the stretchable headrest cover, wherein the headrest cover and the tray table cover are compressed.

Abstract: Disclosed are various embodiments for an intravascular catheter and methods of use. In one embodiment, an intravascular catheter and needle assembly comprises a catheter needle and a catheter sheath surrounding a portion of the catheter needle. The catheter sheath has an end for insertion that is angled between 5 and 85 degrees.

Abstract: A hygienic kit and a method thereof for a hygienic seat location including a stretchable antimicrobial hygienic headrest cover having an ability to conform itself to dimensions of the existing headrest. The cover comprises a stretchable, antimicrobial, a non-mesh fabric configured to provide an impenetrable barrier between a user and the headrest. The headrest has an elastic opening in the back surface allowing the fabric to stretchily fit over an existing headrest. A tray table cover defined by a top panel, a bottom panel, and a sidewall connecting said top and bottom panels thereby creating an opening to a cavity therein is included. A pre-packaged sanitizing wipe is included to sanitize the seating location, and a container is included to encapsulate the pre-packaged sanitizing wipe, the tray table cover, and the stretchable headrest cover, wherein the headrest cover and the tray table cover are compressed.

Abstract: A stretchable hygienic cover, for utilization with an existing variable geometry vehicle headrest, having an ability to conform itself to dimensions of the existing variable geometry vehicle headrest underlying the stretchable hygienic cover when engaged includes a stretchable, breathable, moisture-absorbent fabric. Further provided in the stretchable hygienic cover is an elastic opening allowing the fabric to stretchably fit over an existing variable geometry vehicle headrest, wherein the elastic opening may stretch and retract in size to grip on to an existing variable geometry vehicle headrest. Also provided is a hygienic kit for a headrest and a method for a hygienic kit for a headrest.

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

Abstract: A stretchable hygienic cover, for utilization with an existing variable geometry vehicle headrest, having an ability to conform itself to dimensions of the existing variable geometry vehicle headrest underlying the stretchable hygienic cover when engaged includes a stretchable, breathable, moisture-absorbent fabric. Further provided in the stretchable hygienic cover is an elastic opening allowing the fabric to stretchably fit over an existing variable geometry vehicle headrest, wherein the elastic opening may stretch and retract in size to grip on to an existing variable geometry vehicle headrest. Also provided is a hygienic kit for a headrest and a method for a hygienic kit for a headrest.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure.

Abstract: A stretchable hygienic cover, for utilization with an existing variable geometry vehicle headrest, having an ability to conform itself to dimensions of the existing variable geometry vehicle headrest underlying the stretchable hygienic cover when engaged includes a stretchable, breathable, moisture-absorbent fabric. Further provided in the stretchable hygienic cover is a closable opening allowing the fabric to stretchably fit over an existing variable geometry vehicle headrest, wherein the closable opening may stretch and retract in size to grip on to an existing variable geometry vehicle headrest. The fabric includes at least two vertical internal bands of resilient material having a greater modulus of elasticity than that of said fabric to allow for a secure engagement to the surface of the headrest. These bands are secured within said fabric.

Abstract: The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the invention. The present invention further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds ad compositions of the invention.

Abstract: A high heat polymer with improved sound deadening properties is provided. The material includes recycled PET (Polyethylene terephthalate) as its base polymer and combination of mineral fillers and fibers to improve heat deflection temperatures and to create a barrier within the polymer that blocks noise. The material uses use a combination of basalt fibers and mica to provide improved resistance to heat and improved elastic modulus and significant dampening of sound. The high heat performance and improved sound attenuation of the material enables the deletion of heat shields and added NVH pads to many under body and under-hood parts, as well as significantly reducing the material cost and weight in automobiles.

Abstract: A stretchable hygienic cover, for utilization with an existing variable geometry vehicle headrest, having an ability to conform itself to dimensions of the existing variable geometry vehicle headrest underlying the stretchable hygienic cover when engaged includes a stretchable, breathable, moisture-absorbent fabric. Further provided in the stretchable hygienic cover is a closable opening allowing the fabric to stretchably fit over an existing variable geometry vehicle headrest, wherein the closable opening may stretch and retract in size to grip on to an existing variable geometry vehicle headrest. The fabric includes at least two vertical internal bands of resilient material having a greater modulus of elasticity than that of said fabric to allow for a secure engagement to the surface of the headrest. These bands are secured within said fabric.

Abstract: Provided herein, inter alia, are compounds and methods of treating diseases including cancer, neurological disease, alcohol withdrawal, depression and anxiety, and neuropathic pain.

Abstract: A retractable running board assembly according to an exemplary aspect of the present disclosure includes, among other things, a running board and a linkage connected to the running board. The linkage includes a hinge provided by a pin rotatable relative to a bushing, which is provided in a recess in the linkage. Further, a seal is provided in the recess between the bushing and an opening of the recess.

Abstract: A retractable running board assembly according to an exemplary aspect of the present disclosure includes, among other things, a running board and a linkage connected to the running board. The linkage includes a hinge provided by a pin rotatable relative to a bushing, which is bushing provided in a recess in the linkage. Further, a seal is provided in the recess between the bushing and an opening of the recess.

Abstract: A high heat polymer with improved sound deadening properties is provided. The material includes recycled PET (Polyethylene terephthalate) as its base polymer and combination of mineral fillers and fibers to improve heat deflection temperatures and to create a barrier within the polymer that blocks noise. The material uses use a combination of basalt fibers and mica to provide improved resistance to heat and improved elastic modulus and significant dampening of sound. The high heat performance and improved sound attenuation of the material enables the deletion of heat shields and added NVH pads to many under body and under-hood parts, as well as significantly reducing the material cost and weight in automobiles.