Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: A system can include an axial field rotary energy device with an axis of rotation and a rotor coaxial with the axis and having a shaft, bearings, rotor disks that are coaxial and permanent magnets on each rotor disk. A printed circuit board (PCB) stator is located between the rotor disks to define an air gap on each side of the PCB stator. An enclosure has two enclosure sections with an inspection port. Bearing caps and bearings are mounted to the rotor. A variable frequency drive (VFD) assembly is coupled to the axial field rotary energy device. The VFD has a flexible conduit that extends between the VFD housing and the axial field rotary energy device. The flexible conduit can adapt to different sizes of axial field rotary energy devices.

Abstract: There is provided a compound of formula I or a pharmacologically acceptable salt thereof for use in a method of treating Hodgkin lymphoma in a patient in need thereof comprising administering to said patient an effective amount of said compound of formula I or a pharmacologically acceptable salt thereof: a combination of said compound of formula I or a pharmaceutically acceptable salt thereof with Brentuximab Vedotin and said combination for use in a method of treating Hodgkin lymphoma in a patient in need thereof comprising administering to said patient an effective amount of said combination.

Abstract: A system has an axial field rotary energy device with a housing, an axis and a rotor with a shaft, bearings, rotor disks and permanent magnets. A printed circuit board (PCB) stator is between the rotor disks to define an air gap on each side thereof. A variable frequency drive (VFD) assembly has a VFD housing and first pads coupled to inductors to facilitate heat removal from the inductors. A concave cradle is coupled to a ferromagnetic core and has a same contour as an outer surface of the ferromagnetic core. A second pad is coupled to a rectifier module. A third pad is coupled to switching devices and has pins to align the switching devices with the third pad. Standoffs are coupled to the VFD housing to support a first printed circuit board assembly (PCBA). A second PCBA is mounted to a shield plate above the first PCBA.

Abstract: A method and apparatus is provided for the continuous microwave depolymerization of high molecular weight organic feedstock material, such as waste plastics and includes intermittent or continuous feeding of the processing material on the surface or into the bulk of the sensitized hot bed located under microwave irradiation. As a result of the interaction of electromagnetic field with processed materials, sensitizer is heated by microwave energy and feedstock material undergoes the depolymerization reactions. The reaction zone can be localized on the surface of the hot bed or distributed in the bulk of the reaction mass depending on the agitation conditions of the reaction mass, such as stirring, or other agitation means, for example by re-circulated gas. Products of the reactions are vaporized and transported to the collection system, which may include a combination of a scrubber, a condenser and a settler.

Abstract: A method and apparatus is provided for the continuous microwave depolymerization of high molecular weight organic feedstock material, such as waste plastics and includes intermittent or continuous feeding of the processing material on the surface or into the bulk of the sensitized hot bed located under microwave irradiation. As a result of the interaction of electromagnetic field with processed materials, sensitizer is heated by microwave energy and feedstock material undergoes the depolymerization reactions. The reaction zone can be localized on the surface of the hot bed or distributed in the bulk of the reaction mass depending on the agitation conditions of the reaction mass, such as stirring, or other agitation means, for example by re-circulated gas. Products of the reactions are vaporized and transported to the collection system, which may include a combination of a scrubber, a condenser and a settler.

Abstract: A method and apparatus is provided for the continuous microwave depolymerization of high molecular weight organic feedstock material, such as waste plastics and includes intermittent or continuous feeding of the processing material on the surface or into the bulk of the sensitized hot bed located under microwave irradiation. As a result of the interaction of electromagnetic field with processed materials, sensitizer is heated by microwave energy and feedstock material undergoes the depolymerization reactions. The reaction zone can be localized on the surface of the hot bed or distributed in the bulk of the reaction mass depending on the agitation conditions of the reaction mass, such as stirring, or other agitation means, for example by recirculated gas. Products of the reactions are vaporized and transported to the collection system, which may include a combination of a scrubber, a condenser and a settler.

Abstract: A method and apparatus is provided for the continuous microwave depolymerization of high molecular weight organic feedstock material, such as waste plastics and includes intermittent or continuous feeding of the processing material on the surface or into the bulk of the sensitized hot bed located under microwave irradiation. As a result of the interaction of electromagnetic field with processed materials, sensitizer is heated by microwave energy and feedstock material undergoes the depolymerization reactions. The reaction zone can be localized on the surface of the hot bed or distributed in the bulk of the reaction mass depending on the agitation conditions of the reaction mass, such as stirring, or other agitation means, for example by re-circulated gas. Products of the reactions are vaporized and transported to the collection system, which may include a combination of a scrubber, a condenser and a settler.

Abstract: A method and apparatus is provided for the continuous microwave depolymerization of high molecular weight organic feedstock material, such as waste plastics and includes intermittent or continuous feeding of the processing material on the surface or into the bulk of the sensitized hot bed located under microwave irradiation. As a result of the interaction of electromagnetic field with processed materials, sensitizer is heated by microwave energy and feedstock material undergoes the depolymerization reactions. The reaction zone can be localized on the surface of the hot bed or distributed in the bulk of the reaction mass depending on the agitation conditions of the reaction mass, such as stirring, or other agitation means, for example by re-circulated gas. Products of the reactions are vaporized and transported to the collection system, which may include a combination of a scrubber, a condenser and a settler.

Abstract: An apparatus and method of making the same for sensing inclination. The apparatus includes a member moveably positioned in a body, the member moves in response to gravity between two positions if the body is rotated relative to an axis exceeding a certain amount. A detector can be used to detect when the member moves and can automatically report rotation. A method of making an inclinometer includes creating the body by laminating layers, where a layer is prefabricated to include an appropriate cut-out to guide the member between the two positions. Another layer or layers can include the detector. An aspect of the invention comprises having each layer include prefabricated features for multiple inclinometers, and then superposing the prefabricated layers, activating adhesive between them to form a lamination defining a plurality of inclinometers, and then separating the lamination into individual inclinometers.

Abstract: An apparatus and method of making the same for sensing inclination. The apparatus includes a member moveably positioned in a body, the member moves in response to gravity between two positions if the body is rotated relative to an axis exceeding a certain amount. A detector can be used to detect when the member moves and can automatically report rotation. A method of making an inclinometer includes creating the body by laminating layers, where a layer is prefabricated to include an appropriate cut-out to guide the member between the two positions. Another layer or layers can include the detector. An aspect of the invention comprises having each layer include prefabricated features for multiple inclinometers, and then superposing the prefabricated layers, activating adhesive between them to form a lamination defining a plurality of inclinometers, and then separating the lamination into individual inclinometers.