Abstract: Disclosed herein are compounds that are Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors having a structure according to Formula I, and compositions containing those compounds. Methods of preparing the compounds, and methods of using the compounds for the treatment of diseases, disorders, or conditions are also described.

Abstract: A therapeutic ultrasound method configured to adaptively transmit ultrasound pulses toward microbubbles in a treatment region to remove an occlusion is described. In some examples, the system may include a treatment pulse unit configured to transmit an ultrasound pulse to a treatment region of a subject, the treatment region including a plurality of microbubbles. An echo detection unit may be configured to receive one or more echoes responsive to the ultrasound pulse. In some examples, the method may also include a data processor configured to identify, using data associated with the echoes, at least one echo signature indicative of a dynamic state of the microbubbles in response to the ultrasound pulse. A controller may be configured to adjust one or more parameters of an additional ultrasound pulse transmitted to the treatment region via the treatment pulse unit based on the at least one echo signature.

Abstract: Compounds, such as compounds having Formula (I): wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: Surgical instruments for interfacing with implants can include an inserter configured to dock to a unilateral portion of an implant. The inserter can include a control shaft that is configured to lock or unlock the inserter coupling with the implant. Actuation of the control shaft can occur by way of a knob that can control movement of the control shaft. The inserter can facilitate positioning of the implant relative to a surgical site and allow for application of counter-torque when imparting torque for tightening a set screw, etc. Additional instruments can also be used to manipulate the implant. For example, auxiliary instruments can be coupled to the inserter, such as a reducer instrument, to facilitate rod reduction, etc. Alternatively or in addition, a holder instrument can be used that has a threaded distal engagement feature for coupling to the implant to facilitate positioning thereof.

Abstract: Systems and techniques for grasp selection may include receiving one or more candidate object trajectories and a current grasp of a robotic hand on an object, sampling random candidate grasps for the one or more candidate object trajectories based on the current grasp, generating one or more grasps to be optimized for each of the one or more candidate object trajectories based on the sampled candidate grasps, and optimizing one or more of the grasps to be optimized for each of the one or more candidate object trajectories based on a cost function.

Abstract: Methods for converting mixtures of anthocyanins occurring in fruit or vegetable juice or extract into particular anthocyanin molecules having desirable colorant properties are provided herein. The method of the present disclosure can be employed to increase the amount of particular anthocyanin molecules, while lowering the total number of anthocyanin molecules present in the natural juice and/or extract. The disclosure is also directed to anthocyanin molecules prepared by the methods of present disclosure and to enzymes capable of catalyzing reactions that provide such effects.

Abstract: A technique for generating and presenting context-aware recommendations to assist a patient in managing a chronic health condition. A health management platform provides various services that are accessible to a patient via a graphical user interface (GUI). Input data are received from various services and processed to generate contextual data associated with the patient such as a health state of the patient. Using the contextual data, a recommendation to access a particular service is generated and presented to the patient via the GUI. For example, in response to determining a health state of a patient, a recommendation to access a service to improve the health state of the patient can be automatically presented via the GUI to encourage the patient to access the service.

Abstract: A circuit arrangement includes a preprocessing circuit configured to obtain context information related to a user location, a learning circuit configured to determine a predicted user movement based on context information related to a user location to obtain a predicted route and to determine predicted radio conditions along the predicted route, and a decision circuit configured to, based on the predicted radio conditions, identify one or more first areas expected to have a first type of radio conditions and one or more second areas expected to have a second type of radio conditions different from the first type of radio conditions and to control radio activity while traveling on the predicted route according to the one or more first areas and the one or more second areas.

Abstract: Systems and methods for apportioning cloud-based resources through the use of domain name services based on real-time cloud-based database engine traffic patterns. For example, the system may monitor incoming cloud-based database engine traffic over a plurality of disparate computer network resources. The system may generate a first recommendation for domain name service based on the first difference, wherein the first recommendation requests a modification of an allocation of the plurality of disparate computer network resources.

Abstract: A welding screen includes a primary barrier made of a magnetic sheet. The welding screen enhances safety by halting or restricting the motion of magnetic and paramagnetic by-products, thereby preventing flame, light, magnetic material, sparks and dust from being scattered during welding or post-weld grinding. This improvement can be applied to various type of welding screens (welding curtain, welding windshield), by using a flexible magnetic sheet material as the primary barrier material.

Abstract: A system and method for the in situ processing of internal SRF cavity surfaces to reduce field emission and improve maximum gradient. An electromagnetic radiation source is introduced in the bore of a superconducting cavity to enhance ionization or dissociation of gases which then remove contaminants from the surface of the cavity, either through direct surface bombardment, chemical reaction or through the production of radiation which interacts with the contaminants. An RF or low frequency electromagnetic field may be established in the cavity which further enhances the ionization or dissociation process and may cause the ions to bombard sites with enhanced electric fields. The invention removes the requirement that the RF field be sufficient by itself to ionize gas in the cavity.

Abstract: A system and method for the in situ processing of internal SRF cavity surfaces to reduce field emission and improve maximum gradient. An electromagnetic radiation source is introduced in the bore of a superconducting cavity to enhance ionization or dissociation of gases which then remove contaminants from the surface of the cavity, either through direct surface bombardment, chemical reaction or through the production of radiation which interacts with the contaminants. An RF or low frequency electromagnetic field may be established in the cavity which further enhances the ionization or dissociation process and may cause the ions to bombard sites with enhanced electric fields. The invention removes the requirement that the RF field be sufficient by itself to ionize gas in the cavity. The in situ processing method could enable exposure of the entire internal surface of multiple cells in an RF structure to ionized or dissociated gas simultaneously rather than on a cell by cell basis.

Abstract: A method of determining the beam position in an energy recovered linac (ERL). The method makes use of in phase and quadrature (I/Q) demodulation techniques to separate the pickup signal generated by the electromagnetic fields generated by the first and second pass beam in the energy recovered linac. The method includes using analog or digital based I/Q demodulation techniques in order to measure the relative amplitude of the signals from a position sensitive beam pickup such as a button, strip line or microstripline beam position monitor.

Abstract: A welding spatter protection screen formed primarily of magnetic sheeting or being a magnet is provided to further safety by halting or restricting the motion of magnetic and paramagnetic by-products, thereby preventing flame, light, magnetic material, sparks and dust from being scattered during welding or post-weld grinding. This improvement can be applied to various type of welding screens (welding curtain, welding windshield), by using a flexible magnetic sheet material as the primary barrier material.

Abstract: A method of selecting an appropriate resin bonded sorbent composition which may be used at least for in part making an enclosure to protect contents from external humidity including the steps of: a) selecting a plurality of resins, a plurality of sorbents and a plurality of ratios therebetween to form a plurality of composites; b) calculating a plurality of failure times for the plurality of composites, wherein each failure time of the plurality of failure times is based on when an internal relative humidity of each composite of the plurality of composites is equal to the maximum internal relative humidity; c) determining which of the plurality of failure times is greater; and, d) selecting one composite of the plurality of composites based on the result of step (c).

Abstract: A lamp assembly including at least one light source, a housing formed from a first moisture barrier composition and a sealing cap formed from a second moisture barrier composition, wherein the at least one light source is arranged within the housing and the sealing cap is hermetically bonded to the housing and the at least one light source, and the sealing cap is arranged to enclose the at least one light source within a volume formed by the housing and the sealing cap.

Abstract: A method of selecting an appropriate resin bonded sorbent composition which may be used at least for in part making an enclosure to protect contents from external humidity including the steps of: a) selecting a plurality of resins, a plurality of sorbents and a plurality of ratios therebetween to form a plurality of composites; b) calculating a plurality of failure times for the plurality of composites, wherein each failure time of the plurality of failure times is based on when an internal relative humidity of each composite of the plurality of composites is equal to the maximum internal relative humidity; c) determining which of the plurality of failure times is greater; and, d) selecting one composite of the plurality of composites based on the result of step (c).

Abstract: A method of selecting an appropriate resin bonded sorbent composition which may be used at least for in part making an enclosure to protect contents from external humidity including the steps of: a) selecting a plurality of resins, a plurality of sorbents and a plurality of ratios therebetween to form a plurality of composites; b) calculating a plurality of failure times for the plurality of composites, wherein each failure time of the plurality of failure times is based on when an internal relative humidity of each composite of the plurality of composites is equal to the maximum internal relative humidity; c) determining which of the plurality of failure times is greater; and, d) selecting one composite of the plurality of composites based on the result of step (c).

Abstract: An oxygen-absorbing composition, device, and method for oxygen scavenging in a low moisture environment are provided. The present invention provides an oxygen absorbing composition which includes an oxygen reducing agent, water, a carrier, an electrolyte salt, and a humectant salt, which may be the same as the electrolyte salt, present in an amount sufficient to reduce the water activity of the composition to below 0.6. Also included are methods of using the composition.

Abstract: The present invention is directed to syringe assemblies comprising detachable needle assemblies, that are configured in such a manner as to minimize the dead space after deployment of the syringe piston and injection of the material in the syringe into a patient's body, as well as with bevel indicators that provide guidance as to optimal angles at which to inject the needles into patients.