Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: A multi-fiber cable assembly includes a pigtail segments spliced to a trunk segment using multiple mass fusion splices. The splices are disposed within an encapsulation at a common axial location. A flexible conduit extends from one end of the encapsulation to protect bare fibers of the trunk segment. A protective sheath extends from the opposite end of the encapsulation to protect the pigtail segments. The conduit and sheath are axially fixed to the encapsulation.

Abstract: A surgical system includes a surgical instrument that is sensitive to backlash that would adversely affect the transmission of controlled torque and position to the surgical instrument. The surgical instrument is coupled to motors in a surgical instrument manipulator assembly via a mechanical interface. The combination of the mechanical interface and surgical instrument manipulator assembly have low backlash, e.g., less than 0.7 degrees. The backlash is controlled in the surgical instrument manipulator assembly. From the drive output disk in the surgical instrument manipulator assembly to the driven disk of the surgical instrument, the mechanical interface has zero backlash for torque levels used in surgical procedures.

Abstract: A mattress comprising a foam base, a foam core, and a foam comfort layer. The foam core may be reinforced with firmer transverse members selectively placed along the length of the core. The core may also include air passages. The comfort layer may comprise interlocking upper and lower layers configured to form ventilation channels that operate in a bellows-like fashion moving moist, warm out and drawing fresh air in as the sleeping body moves and shifts through the sleep cycle. The ventilation channels in the core and the comfort layer provide for effective dissipation of heat and moisture even from the innermost regions of the mattress. A cooling gel top layer may be included, and the entire assembly may be covered with a fabric top panel and surround. The surround may be vented to facilitate air movement in and out of the mattress.

Abstract: A radiation detector includes a pressure-tight housing having a peripheral, cylindrically-shaped wall and opposite end closures. An electrode wire extends through a center of the housing, spaced from the cylindrically-shaped wall. A pressurized detector gas fills the housing, and circuit connections to the electrode wire and the housing permits application of an electric potential thereto. The electrode wire is composed of a material providing a source of alpha particles for ionizing the gas within the housing, generating an alpha peak on the output spectrum distinct from the peak generated by incident neutrons. A related method is also disclosed.

Abstract: A radiation detector is provided having an anode wire formed of an amorphous metal alloy. In one embodiment the radiation detector comprises a cathode assembly. The cathode assembly includes a main portion, a first end and a second end, where the first end opposes the second end. The cathode assembly also includes a radiation interacting material. An anode extends within the cathode assembly from the first end to the second end, and the anode is comprised of an amorphous metal alloy.

Abstract: A radiation detector includes a pressure-tight housing having a peripheral, cylindrically-shaped wall and opposite end closures. An electrode wire extends through a center of the housing, spaced from the cylindrically-shaped wall. A pressurized detector gas fills the housing, and circuit connections to the electrode wire and the housing permits application of an electric potential thereto. The electrode wire is composed of a material providing a source of alpha particles for ionizing the gas within the housing, generating an alpha peak on the output spectrum distinct from the peak generated by incident neutrons. A related method is also disclosed.

Abstract: In one set of embodiments, trimming of a reference, which may be a bandgap reference and which is configured on an integrated circuit, may be controlled by an algorithm executed by logic circuitry also configured on the integrated circuit. The bandgap reference may be configured to generate a reference voltage provided to an analog to digital converter (ADC) comprised in a temperature sensor that may also be configured on the integrated circuit. The logic circuitry may be configured to execute one or more of a variety of test algorithms, for example a Successive Approximation Method or remainder processing, that are operable to adjust values of reference trim bits used in trimming the bandgap reference.

Abstract: A temperature sensor circuit and system providing accurate readings using a temperature diode whose ideality factor may fall within a determined range. In one set of embodiments a change in diode junction voltage (?VBE) proportional to the temperature of the diode is captured and provided to an ADC, which may perform required signal conditioning functions on ?VBE, and provide a numeric value output corresponding to the temperature of the diode. Errors in the measured temperature that might result from using diodes with ideality factors that differ from an expected ideality factor may be eliminated by programming the system to account for differing ideality factors. The gain of the temperature sensor may be matched to the ideality factor of the temperature diode by using an accurate, highly temperature stable reference voltage of the ADC to set the gain of the temperature measurement system.

Abstract: In a wheel supported floor and carpet push brush of the type having an array of aggressive bristles and another array of bristles which are of lesser diameter than the aggressive bristles carried on the dowel so that the brush can be turned over to bring a selected one of the arrays into operative sweeping position, the improvement wherein the average diameter of the aggressive bristles is no greater than about 0.012 inches with a preferred diameter being about 0.010 inches, and the other array of bristles have an average maximum diameter less than 0.010 inches with a preferred diameter being about 0.008 inches.

Abstract: An amplifier circuit. In one embodiment, the amplifier circuit includes an output stage and a gain stage. The gain stage includes first and second differential output terminals that may be coupled to first and second differential input terminals of the output stage. The gain stage includes a first feedback loop and a second feedback loop. First and second half-stages within the gain stage may be coupled to provide the second feedback loop. The first half-stage may be coupled to control a first output current at the first output terminal of the gain stage, while the second-half-stage may be coupled to control a second output current at the second output terminal of the gain stage.

Abstract: A portable auxiliary cooling system for cooling electrical power transformers is provided with an intelligent controller that is programmable for functioning in a plurality of different operational modes. A plurality of sensors monitor cooling system equipment operation, transformer top oil temperature and transformer current. The cooling system controller includes a user-interface panel, a modem and/or other digital communications circuitry, data storage memory and a computer or microprocessor that performs real-time heat removal rate computations and automatically controls heat pump and fan operation in response to the computed results. System performance data, sensor readings and alarm condition indications are indicated on a user-interface panel and may also be provided to a remote station or operator using conventional digital communication facilities.

Abstract: A portable auxiliary cooling system for cooling electrical power transformers is provided with an intelligent controller that is programmable for functioning in a plurality of different operational modes. A plurality of sensors monitor cooling system equipment operation, transformer top oil temperature and transformer current. The cooling system controller includes a user-interface panel, a modem and/or other digital communications circuitry, data storage memory and a computer or microprocessor that performs real-time heat removal rate computations and automatically controls heat pump and fan operation in response to the computed results. System performance data, sensor readings and alarm condition indications are indicated on a user-interface panel and may also be provided to a remote station or operator using conventional digital communication facilities.

Abstract: Methods and associated systems for multi-layered channel marketing catalog generation and maintenance. A plurality of hierarchically related product/service catalogs are maintained so as to maintain commonality with regard to information contained in the catalogs and to permit customization at each layer. Information from a plurality of manufacturer catalogs are provided and integrated into a single master industry catalog Channel marketing partners of the several manufacturers extract information from the industry catalog for the particular manufacturers with whom they have established marketing agreements. The extracted information is then presented as a channel partner catalog to customers/users of the channel partner. Resellers having established relationships with one or more channel partners extract information from the channel partners' catalogs to create a reseller's catalog.

Abstract: A new safety glove for allowing a user, such as a police officer or a road worker, to direct traffic more easily. The inventive device includes a hand cover having an interior hand space, a front, a back, a palm portion, and a wrist opening into the interior hand space. Also provided are front and back reflective panels. The front reflective panel is coupled to the front of the hand cover and the back reflective panel is coupled to the back of the hand cover.

Abstract: A circuit for producing a reference voltage includes an NPN transistor having its emitter connected to a first terminal, its collector connected to a second terminal, a PNP transistor having its emitter connected to the second terminal, its base connected to the base of the NPN transistor, and having its collector connected to the second terminal. A current source is connected to either the first terminal or the second terminal to force a current which is divided into a current through the PNP transistor and another current through the NPN transistor. The circuit produces a reference voltage equal to the sum of the PNP V.sub.BE voltage and the NPN V.sub.BE voltage. The reference voltage tracks precisely with variations in saturation currents of the PNP transistor and the NPN transistor. The circuit is useful in producing a two V.sub.BE bias voltage between the base of an NPN pullup transistor and a PNP pulldown transistor having a common emitter connection to an output terminal.

Abstract: A 12 bit, 10 megahertz subranging analog-to-digital converter produces a sampled analog input signal. The sampled analog signal is converted by an MSB flash encoder to a 7 bit MSB word that is converted to an analog signal by a 7 bit DAC having 14 bit accuracy. The result is subtracted from the sample analog signal to produce a residue signal by means of a high speed amplifier having first and second multiplexed differential input stages, the first input stage having differential inputs receiving the sampled analog input signal and the analog signal produced by the 7 bit DAC. The second differential input stage has one input connected to ground and the other input resistively coupled to the output of the high speed amplifier. The output of the high speed amplifier is resistively coupled to the second input of the first and second differential stages. The multiplexed input high speed amplifier produces an intermediate input level until the output of the DAC is stable.

Abstract: A sail assembly comprising a mast, spaced apart lateral upper and a lower elongated members fixed to the mast, a track joining first ends of the upper and lower members, two panels of sail material one to each side of the mast connected to the track by runners to allow the sail panels to be furled, sail battens mounted in pockets in the two sail panels with the forward ends of the sail battens retained to resist longitudinal compressive forces when applied to the battens to induce a bend therein, battens in the respective sail panels are aligned to provide batten pairs with the rear ends of the battens of each pair where they project from the batten pockets interconnected but relatively movable, and a line and pulley arrangement longitudinal compressive force to the sail battens at a location remote from the forward ends thereof.