Patents by Inventor Thomas R. Berka

Thomas R. Berka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein protease inhibitors from streptomyces
    Patent number: 5498529
    Abstract: This invention relates to a process for producing a heterologous polypeptide in Streptomyces which involves transforming a Streptomyces organism with a recombinant DNA molecule comprising an LEP-10 of LTl sequence selected from the group consisting of a sequence encoding a gene expression unit, a promoter sequence or an export control encoding sequence each operatively linked to a heterologous coding sequence and then culturing the transformed Streptomyces such that the heterologous polypeptide is expressed.
    Type: Grant
    Filed: December 3, 1993
    Date of Patent: March 12, 1996
    Assignee: SmithKline Beckman Corporation
    Inventors: Thomas R. Berka, James A. Fornwald, Joselina G. Gorniak, Martin Rosenberg, James E. Strickler, Dean P. Taylor
  • Protein protease inhibitors from streptomyces
    Patent number: 5279939
    Abstract: This invention relates to novel protein protease inhibitors as well as DNAs encoding same and vectors and transformed host cells useful for the recombinant production of the inhibitors.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: January 18, 1994
    Assignee: SmithKline Beecham Corporation
    Inventors: Thomas R. Berka, James A. Fornwald, Joselina G. Gorniak, Martin Rosenberg, James E. Strickler, Dean P. Taylor
  • Genetically engineered microorganisms containing a gene segment coding for a lipase from Rhizopus delemar
    Patent number: 5219753
    Abstract: A lipase purified from Rhizopus delemar can be produced by cultivating a genetically engineered host microorganism transformed with a gene coding for the lipase. Additionally disclosed is a method for the detection or screening for production of lipase by genetically engineered organisms.
    Type: Grant
    Filed: June 22, 1989
    Date of Patent: June 15, 1993
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Thomas R. Berka, Michael J. Haas