Patents by Inventor Thomas R. Blohm

Thomas R. Blohm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5436237
    Abstract: The present invention relates to 4-amino-.DELTA..sup.4 -steroids which are useful as inhibitors of 5.alpha.-reductase. The compounds are prepared by the reaction of an appropriate 4-azido steroid with triphenylphosphine in an aqueous inert solvent with heating.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: July 25, 1995
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Philip M. Weintraub, Joseph P. Burkhart, Thomas R. Blohm
  • Patent number: 5318961
    Abstract: The present invention relates to 4-amino-.DELTA..sup.4 -steroids which are inhibitors of 5.alpha.-reductase. The compounds are useful for treating DHT-mediated diseases.
    Type: Grant
    Filed: December 20, 1992
    Date of Patent: June 7, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Philip M. Weintraub, Joseph P. Burkhart, Thomas R. Blohm
  • Patent number: 5143909
    Abstract: The present invention relates to a method for the inhibition of C.sub.17-20 lyase enzyme which comprises administering to a patient in need of such inhibition, an effective amount of certain 4-amino-17-(hydroxyalkyl or dihydroxyalkyl)steroids or their esters or ethers. Certain of the aminosteroids used in the process are novel compounds.
    Type: Grant
    Filed: March 19, 1991
    Date of Patent: September 1, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Philip M. Weintraub, Cynthia A. Gates, Thomas R. Blohm
  • Patent number: 5120840
    Abstract: The present invention relates to 4-amino-.DELTA..sup.4 -steroids which are useful as inhibitors of 5.alpha.-reductase. The compounds are prepared by the reaction of an appropriate 4-azido steroid with triphenylphosphine in an aqueous inert solvent with heating.The present application is a continuation-in-part of application Ser. No. 561,041, filed Aug. 1, 1990 and application Ser. No. 671,555, filed Mar. 19, 1991.
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: June 9, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Philip M. Weintraub, Joseph P. Burkhart, Thomas R. Blohm
  • Patent number: 5100917
    Abstract: The present invention relates to novel A-nor-steroid-3-carboxylic acid derivatives and to their use as inhibitors of mammalian 5.alpha.-reductase.
    Type: Grant
    Filed: September 11, 1990
    Date of Patent: March 31, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gary A. Flynn, Philippe Bey, Thomas R. Blohm
  • Patent number: 5075464
    Abstract: This invention is directed to 17.beta.-(cyclopropylamino)androstenes and also to a method for using such compounds in the treatment of androgen-dependent disorders. The compounds are prepared by the hydride reduction of an appropriate steroidal imine or enamine.
    Type: Grant
    Filed: June 14, 1989
    Date of Patent: December 24, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Thomas R. Blohm, Michael R. Angelastro
  • Patent number: 4966898
    Abstract: This invention is directed to 4-substituted 17.beta.-(cyclopropylamino)androst-5-en-3.beta.-ol and related compounds and also to a method for using such compounds in the treatment of androgen-dependent disorders. The compounds are prepared by the hydride reduction of an appropriate steroidal imine or enamine.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: October 30, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael R. Angelastro, Thomas R. Blohm
  • Patent number: 4966897
    Abstract: This invention is directed to 4-substituted 17.beta.-(cyclopropyloxy)androst-5-en-3.beta.-ols and related compounds and also to a method for using such compounds in the treatment of androgen-dependent disorders. The ethers are prepared by using the Simmons-Smith reaction and an appropriate vinyl ether.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: October 30, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael R. Angelastro, Thomas R. Blohm
  • Patent number: 4891367
    Abstract: This invention is directed to 17.beta.-(cyclopropyloxy)androst-5-en-3.beta.-ol and related compounds and also to a method for using such compounds in the treatment of androgen-dependent disorders. The ethers are prepared by using the Simmons-Smith reaction and an appropriate vinyl ether.
    Type: Grant
    Filed: April 22, 1987
    Date of Patent: January 2, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael R. Angelastro, Thomas R. Blohm
  • Patent number: 4317817
    Abstract: Compounds of the following general formula are testosterone 5.alpha.-reductase inhibitors rendering the compounds useful in the treatment of acne and oily skin and benign prostatic hypertrophy: ##STR1## wherein R is: .dbd.O, --OH, --OCO--alkyl C.sub.1-5, --COOH, --CH.sub.2 OH, --COO--alkyl C.sub.1-6, --COCH.sub.
    Type: Grant
    Filed: December 15, 1980
    Date of Patent: March 2, 1982
    Assignee: Richardson-Merrell Inc.
    Inventors: Thomas R. Blohm, Brian W. Metcalf
  • Patent number: 4187319
    Abstract: Substituted benzaldehydes of the following general structure are useful as hypolipidemic agents: ##STR1## wherein Y is selected from oxygen and divalent sulfur; R is selected from a straight or branched saturated hydrocarbon chain having from 10 to 20 carbon atoms and a straight or branched unsaturated hydrocarbon chain having from 10 to 20 carbon atoms and from 1 to 4 double bonds.
    Type: Grant
    Filed: June 2, 1977
    Date of Patent: February 5, 1980
    Assignee: Richardson-Merrell Inc.
    Inventors: Thomas R. Blohm, J. Martin Grisar, Roger A. Parker
  • Patent number: 4153235
    Abstract: Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic acitivity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
    Type: Grant
    Filed: February 14, 1978
    Date of Patent: May 8, 1979
    Assignee: Richardson-Merrell Inc.
    Inventors: Johann M. Grisar, Thomas R. Blohm, Edward M. Roberts
  • Patent number: 4126611
    Abstract: Compounds possessing hypoglycemic, hypotensive, antiinflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
    Type: Grant
    Filed: February 14, 1978
    Date of Patent: November 21, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Johann M. Grisar, Thomas R. Blohm, Edward M. Roberts
  • Patent number: 4126613
    Abstract: Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## where Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
    Type: Grant
    Filed: August 9, 1973
    Date of Patent: November 21, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Johann M. Grisar, Thomas R. Blohm, Edward M. Roberts
  • Patent number: 4126621
    Abstract: Compounds possessing hypoglycemic, hypotensive, antiinflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
    Type: Grant
    Filed: February 14, 1978
    Date of Patent: November 21, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Johann M. Grisar, Thomas R. Blohm, Edward M. Roberts
  • Patent number: 4126612
    Abstract: Compounds possessing hypoglycemic, hypotensive, anti-inflammatory, anticoagulant and diuretic activity are represented by compounds of the following formula ##STR1## wherein Y is thienyl, cycloalkyl of from 5 to 7 carbon atoms, phenyl or substituted phenyl in which case the substituents on the substituted phenyl are selected from halogen, such as fluorine, chlorine, bromine or iodine, lower alkyl of from 1 to 4 carbon atoms and lower alkoxy of from 1 to 4 carbon atoms; Z is hydrogen or hydroxy; R is hydrogen, lower alkyl of from 1 to 4 carbon atoms, phenyl or benzyl; R.sup.1 is hydrogen, lower alkyl of from 1 to 4 carbon atoms or halogen, such as chlorine, fluorine, bromine or iodine; m is from 3 to 6; and n is from 3 to 11. Pharmaceutical compositions of these compounds and their use are also disclosed.
    Type: Grant
    Filed: February 14, 1978
    Date of Patent: November 21, 1978
    Assignees: Eugene O. Retter, Richardson-Merrell Inc.
    Inventors: Johann M. Grisar, Thomas R. Blohm, Edward M. Roberts
  • Patent number: 4088760
    Abstract: Compounds of the following general formula are testosterone 5.alpha.-reductase inhibitors rendering said compounds useful in the treatment of acne and oily skin: ##STR1## wherein n is an integer of from 0 to 4; R.sub.1 is --COOR.sub.2, --CONR.sub.3 R.sub.4, --CHO or --CH.sub.2 OR.sub.5 ; R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or benzyl; each of R.sub.3 and R.sub.4 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms; and R.sub.5 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 20 carbon atoms and is straight or branched, benzoyl, phenylalkylcarbonyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched, or cycloalkylcarbonyl wherein the cycloalkyl moiety has from 5 to 10 carbon atoms.
    Type: Grant
    Filed: June 23, 1976
    Date of Patent: May 9, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Harvey D. Benson, Thomas R. Blohm
  • Patent number: 4066788
    Abstract: Substituted benzaldehydes of the following general structure are useful as hypolipidemic agents: ##STR1## wherein Y is selected from oxygen and divalent sulfur; R is selected from a straight or branched saturated hydrocarbon chain having from 10 to 20 carbon atoms and a straight or branched unsaturated hydrocarbon chain having from 10 to 20 carbon atoms and from 1 to 4 double bonds.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: January 3, 1978
    Assignee: Richardson-Merrell Inc.
    Inventors: Thomas R. Blohm, J. Martin Grisar, Roger Alan Parker
  • Patent number: 4061746
    Abstract: A method of treating gastrointestinal hypersecretions which comprises administering substituted lactamimide derivatives.
    Type: Grant
    Filed: April 23, 1976
    Date of Patent: December 6, 1977
    Assignee: Richardson-Merrell Inc.
    Inventors: Thomas R. Blohm, J. Martin Grisar, Norbert L. Wiech