Patents by Inventor Thomas R. Hoye

Thomas R. Hoye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monomers and polymers formed thereby
    Patent number: 11111206
    Abstract: Monomers, polymers, or oligomers formed therefrom and methods of forming or utilizing monomers of formula I where R1 is a C1 to C4 alkyl; and X is —OH; —OM where M is lithium (Li), sodium (Na), or potassium (K), NH4+, R5NH3+, R52NH2+, R53NH+, R54N+ where R5 can independently be selected from alkyl, benzyl, and combinations thereof; —OR2 where R2 can be a C1 to C4 alkyl, 2-ethylhexyl, or a hydrocarbon moiety of bio-renewable alcohol or a hydrogenated derivative thereof; —NR3R4, —NR3—NR3R4, —NR3—OR4 where R3 and R4 can independently be H, a C1 to C4 alkyl, or combinations thereof.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: September 7, 2021
    Assignee: Regents of the University of Minnesota
    Inventors: Thomas R. Hoye, Nicolas Ball-Jones, Grant W. Fahnhorst
  • MONOMERS AND POLYMERS FORMED THEREBY
    Publication number: 20190084915
    Abstract: Monomers, polymers, or oligomers formed therefrom and methods of forming or utilizing monomers of formula I where R1 is a C1 to C4 alkyl; and X is —OH; —OM where M is lithium (Li), sodium (Na), or potassium (K), NH4+, R5NH3+, R52NH2+, R53NH+, R54N+ where R5 can independently be selected from alkyl, benzyl, and combinations thereof; —OR2 where R2 can be a C1 to C4 alkyl, 2-ethylhexyl, or a hydrocarbon moiety of bio-renewable alcohol or a hydrogenated derivative thereof; —NR3R4, —NR3—NR3R4, —NR3—OR4 where R3 and R4 can independently be H, a C1 to C4 alkyl, or combinations thereof.
    Type: Application
    Filed: September 20, 2018
    Publication date: March 21, 2019
    Inventors: Thomas R. Hoye, Nicolas Ball-Jones, Grant W. Fahnhorst
  • Compounds from renewable resources
    Patent number: 10047100
    Abstract: Compounds of formula III: and salts thereof are disclosed. Also disclosed are methods for preparing compounds of formula III, intermediates useful for preparing compounds of formula III and methods for preparing compounds and materials from compounds of formula III.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: August 14, 2018
    Inventors: Thomas R. Hoye, Ashok Pehere, Shu Xu
  • COMPOUNDS FROM RENEWABLE RESOURCES
    Publication number: 20170291906
    Abstract: Compounds of formula III: and salts thereof are disclosed. Also disclosed are methods for preparing compounds of formula III, intermediates useful for preparing compounds of formula III and methods for preparing compounds and materials from compounds of formula III.
    Type: Application
    Filed: March 30, 2017
    Publication date: October 12, 2017
    Inventors: Thomas R. Hoye, Ashok Pehere, Shu Xu
  • Cyclization methods
    Patent number: 9505789
    Abstract: The invention provides methods for cyclizing poly-yne compounds under mild conditions to provide cyclic compounds.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: November 29, 2016
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Thomas R. Hoye, Beeraiah Baire, Dawen Niu, Patrick H. Willoughby, Brian P. Woods
  • Taxane silicate prodrugs and nanoparticles
    Patent number: 9375484
    Abstract: The invention provides silicate prodrugs comprising a therapeutic agent linked to one or more groups of formula (I): —Si(OR)3 (I); wherein each R independently has any of the values defined herein, as well as nanoparticles comprising such compounds.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: June 28, 2016
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Thomas R. Hoye, Adam Wohl, Christopher W. Macosko, Jayanth Panyam
  • SILICATE PRODRUGS AND NANOPARTICLES
    Publication number: 20140213550
    Abstract: The invention provides silicate prodrugs comprising a therapeutic agent linked to one or more groups of formula (I): —Si(OR)3 (I); wherein each R independently has any of the values defined herein, as well as nanoparticles comprising such compounds.
    Type: Application
    Filed: May 31, 2012
    Publication date: July 31, 2014
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Thomas R. Hoye, Adam Wohl, Christopher W. Macosko, Jaynath Panyam
  • Calixarene-based peptide conformation mimetics, methods of use, and methods of making
    Patent number: 8716343
    Abstract: A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: May 6, 2014
    Assignee: Regents of the University of Minnesota
    Inventors: Kevin H. Mayo, Thomas R. Hoye, Xuemei Chen
  • Calixarene-based peptide conformation mimetics, methods of use, and methods of making
    Patent number: 8642656
    Abstract: A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: February 4, 2014
    Assignee: Regents of the University of Minnesota
    Inventors: Kevin H. Mayo, Thomas R. Hoye, Xuemei Chen
  • CALIXARENE-BASED PEPTIDE CONFORMATION MIMETICS, METHODS OF USE, AND METHODS OF MAKING
    Publication number: 20120309801
    Abstract: A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.
    Type: Application
    Filed: April 24, 2012
    Publication date: December 6, 2012
    Applicant: Regents of the University of Minnesota
    Inventors: Kevin H. Mayo, Thomas R. Hoye, Xuemei Chen
  • Calixarene-based peptide conformation mimetics, methods of use, and methods of making
    Patent number: 8207228
    Abstract: A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.
    Type: Grant
    Filed: October 4, 2005
    Date of Patent: June 26, 2012
    Assignee: Regents of the University of Minnesota
    Inventors: Kevin H. Mayo, Thomas R. Hoye, Xuemei Cheri
  • Structural, behavioral characterization, and synthesis of attractants for migratory lamprey
    Patent number: 7557097
    Abstract: Compounds that function as lamprey attractants and methods.
    Type: Grant
    Filed: November 20, 2004
    Date of Patent: July 7, 2009
    Assignee: Regents of the University of Minnesota
    Inventors: Peter W. Sorensen, Thomas R. Hoye, Jared M. Fine, Vadims Dvornikovs, Jizhou Wang, Lance A. Vrieze
  • Calixarene-Based Peptide Conformation Mimetics, Methods of Use, and Methods of Making
    Publication number: 20080300164
    Abstract: A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described.
    Type: Application
    Filed: October 4, 2005
    Publication date: December 4, 2008
    Applicant: Regents of the University of Minnesota
    Inventors: Kevin H. Mayo, Thomas R. Hoye, Xuemei Chen
  • Partial peptide mimetics and methods
    Patent number: 7339023
    Abstract: Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO:8), a homolog thereof, or a segment of SEQ ID NO:8 or a homolog thereof, a second amino acid sequence comprising IIVKLND (SEQ ID NO:2), a homolog thereof, or a segment of SEQ ID NO:2 or a homolog thereof, and a ?-turn inducing scaffold bonded between the first and second amino acid sequences.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: March 4, 2008
    Assignee: Regents of the University of Minnesota
    Inventors: Kevin H. Mayo, Thomas R. Hoye, Carolee Flader-Lavey
  • Partial peptide mimetics and methods
    Patent number: 7056514
    Abstract: Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO:8), a homolog thereof, or a segment of SEQ ID NO:8 or a homolog thereof, a second amino acid sequence comprising IIVKLND (SEQ ID NO:2), a homolog thereof, or a segment of SEQ ID NO:2 or a homolog thereof, and a ?-turn inducing scaffold bonded between the first and second amino acid sequences.
    Type: Grant
    Filed: February 20, 2003
    Date of Patent: June 6, 2006
    Assignee: Regents of the University of Minnesota
    Inventors: Kevin H. Mayo, Thomas R. Hoye, Carolee Flader Lavey
  • Partial peptide mimetics and methods
    Publication number: 20040053828
    Abstract: Partial peptide mimetics and methods of making and using, wherein the partial peptide mimetics have a first amino acid sequence comprising ANIKLSVQMKL (SEQ ID NO: 8), a homolog thereof, or a segment of SEQ ID NO: 8 or a homolog thereof, a second amino acid sequence comprising IIVKLND (SEQ ID NO: 2), a homolog thereof, or a segment of SEQ ID NO: 2 or a homolog thereof, and a &bgr;-turn inducing scaffold bonded between the first and second amino acid sequences.
    Type: Application
    Filed: February 20, 2003
    Publication date: March 18, 2004
    Applicant: Regents of the University of Minnesota
    Inventors: Kevin H. Mayo, Thomas R. Hoye, Carolee Flader
  • Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
    Patent number: 5849936
    Abstract: A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.
    Type: Grant
    Filed: July 25, 1996
    Date of Patent: December 15, 1998
    Assignee: Regents of the Univeristy of Minnesota
    Inventors: Thomas R. Hoye, Lushi Tan
  • Synthesis of acetogenins
    Patent number: 5739358
    Abstract: A method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enzyme.
    Type: Grant
    Filed: May 13, 1997
    Date of Patent: April 14, 1998
    Assignee: Regents of the University of Minnesota
    Inventors: Thomas R. Hoye, Zhixiong Ye
  • Synthesis of acetogenins
    Patent number: 5677467
    Abstract: A method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: October 14, 1997
    Assignee: Regents of the University of Minnesota
    Inventors: Thomas R. Hoye, Zhixiong Ye
  • Method for the synthesis of bis-tetrahydrofuranyl Annonaceous acetogenins
    Patent number: 5587491
    Abstract: A method for the synthesis of bis-tetrahydrofuranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.
    Type: Grant
    Filed: March 15, 1995
    Date of Patent: December 24, 1996
    Assignee: Regents of the University of Minnesota
    Inventors: Thomas R. Hoye, Lushi Tan