Abstract: A tool management system includes a plurality of individual tool retention units that are in electronic communication with a central webserver. Each tool retention unit is designed to independently monitor a designated toolset and transmit tool use data to the webserver. The data compiled by the webserver can be routinely evaluated to ensure proper accountability of all tools within a particular workspace. Due to the autonomous nature of each unit, subsets of tools within a larger monitored collection can be added, removed or replaced without disruption of monitoring amongst the remainder of tools. In one embodiment, a tool retention unit is constructed as a chest comprising a plurality of individual, swappable drawers housed within a common frame. In use, each drawer is provided with a controller that is configured to monitor its designated toolset and transmit any tool-related data to a main controller in communication with the webserver.

Abstract: A sensor including a flexible channel defining a fluid flow path, the flexible channel configured to at least partially deflect when a force is imparted on the flexible channel. A gel layer is in contact with an outer surface of the flexible channel, and a transducer is in contact with the gel layer. Transducer is configured to generate an output signal that corresponds to an amount of strain imparted on the flexible channel.

Abstract: A tool management system includes a plurality of individual tool retention units that are in electronic communication with a central webserver. Each tool retention unit is designed to independently monitor a designated toolset and transmit tool use data to the webserver. The data compiled by the webserver can be routinely evaluated to ensure proper accountability of all tools within a particular workspace. Due to the autonomous nature of each unit, subsets of tools within a larger monitored collection can be added, removed or replaced without disruption of monitoring amongst the remainder of tools. In one embodiment, a tool retention unit is constructed as a chest comprising a plurality of individual, swappable drawers housed within a common frame. In use, each drawer is provided with a controller that is configured to monitor its designated toolset and transmit any tool-related data to a main controller in communication with the webserver.

Abstract: A sensor including a flexible channel defining a fluid flow path, the flexible channel configured to at least partially deflect when a force is imparted on the flexible channel. A gel layer is in contact with an outer surface of the flexible channel, and a transducer is in contact with the gel layer. Transducer is configured to generate an output signal that corresponds to an amount of strain imparted on the flexible channel.

Abstract: Novel methods and devices are disclosed for automatically producing a simulated moving bed chromatography system and parameters from input of a fixed-bed liquid chromatography process directed at separating the same product. Tools and algorithms are provided which automatically convert fixed-bed process parameters into an executable simulated moving bed chromatography program. Familiar tabular input interfaces and a unique circular phase map of the simulated moving bed system that is generated according to input data makes the methods and apparatus of the invention extremely user-friendly and easy to use.

Abstract: A self-contained sampling probe characterized by a drive module and a syringe module removably coupled coaxially to the drive module to allow for different syringe modules to be interchangeably coupled to the drive module. The coupling is effected by quick connect and disconnect devices, and the syringe module may carry an identifier. The probe is engageable by a gripper or insertable in an interface device, both of which provide for communication of the probe with other system components. The probe has a dimension that is 8 mm or less in at least one projection coincident with an aspirate/dispense axis of the probe.

Abstract: An analytical system and method that enables more efficient transport of movable devices (22) among stations (24, 25, 26). According to one aspect of the invention, the system and method permit operational timesharing of a transport mechanism (34) for the movable devices. According to another aspect of the invention, control of the transport mechanism is effected on an event-driven basis. The invention has particular application to an adaptive, motion and fluids system for automating the sample handling/management process associated with analytical processes and especially bioanalytical processes such as introducing samples into LC and HPLC systems.

Abstract: A self-contained sampling probe characterized by a drive module and a syringe module removably coupled coaxially to the drive module to allow for different syringe modules to be interchangeably coupled to the drive module. The coupling is effected by quick connect and disconnect devices, and the syringe module may carry an identifier. The probe is engageable by a gripper or insertable in an interface device, both of which provide for communication of the probe with other system components.

Abstract: A self-contained sampling probe characterized by a drive module and a syringe module removably coupled coaxially to the drive module to allow for different syringe modules to be interchangeably coupled to the drive module. The coupling is effected by quick connect and disconnect devices, and the syringe module may carry an identifier. The probe is engageable by a gripper or insertable in an interface device, both of which provide for communication of the probe with other system components.

Abstract: A self-contained sampling probe characterized by a drive module and a syringe module removably coupled coaxially to the drive module to allow for different syringe modules to be interchangeably coupled to the drive module. The coupling is effected by quick connect and disconnect devices, and the syringe module may carry an identifier. The probe is engageable by a gripper or insertable in an interface device, both of which provide for communication of the probe with other system components.

Abstract: An apparatus and method that address carry-over and contamination resulting from incomplete washing/flushing of syringe surfaces routinely exposed to samples and/or reagents. Specifically, the apparatus and method provide for washing the interior of a syringe barrel as well as interior and exterior surfaces of a syringe needle.

Abstract: A self-cleaning injection port assembly that uses a movable wash chamber closure device (26) for opening and closing an injection needle entry passage (34) of an injection port wash chamber. For sample injection, the wash chamber closure device (26) can be moved clear of the path along which the injection needle passes through the wash chamber into the injection port, thereby enabling insertion of the injection needle into the injection port. For washing, the wash chamber closure device (26) is moved to a position closing the entry passage (34) of the injection port wash, after which cleaning fluid may be circulated through the injection port for cleaning.

Abstract: A self-contained sampling probe characterized by a drive module and a syringe module removably coupled coaxially to the drive module to allow for different syringe modules to be interchangeably coupled to the drive module. The coupling is effected by quick connect and disconnect devices, and the syringe module may carry an identifier. The probe is engageable by a gripper or insertable in an interface device, both of which provide for communication of the probe with other system components.

Abstract: An array of probes is provided wherein the probes are maintained in place in bores extending through a housing by a friction force applied to the probes. The friction force can be overcome by another force applied to the probes, thereby allowing the probes to move to a new position within the bore. In one embodiment, the probes contain an internal conduit through which liquid samples are introduced into the probes. Thereafter, the probes are moved to contact a substrate surface to move the probes to a new position, the configuration of which replicates the substrate surface configuration. The housing is then raised a predetermined distance to allow sample to be accurately deposited on the substrate surface from a desired height above the substrate surface. The probes are then returned to their original position.