Patents by Inventor Thomas R. Malefyt
Thomas R. Malefyt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210177783Abstract: The present invention is directed to tablets for oral administration to a subject, comprising a therapeutically effective amount of SYN120 or a pharmaceutically acceptable salt thereof, wherein the tablet is substantially free of lactose. The present invention is also directed to methods for treating diseases or conditions including Alzheimer's disease and/or Parkinson's disease, comprising administering to a patient in need thereof tablets regarding the same.Type: ApplicationFiled: March 1, 2021Publication date: June 17, 2021Inventors: Christopher G. SALENTINE, Thomas R. MALEFYT
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Patent number: 10973784Abstract: The present invention is directed to tablets for oral administration to a subject, comprising a therapeutically effective amount of SYN120 or a pharmaceutically acceptable salt thereof, wherein the tablet is substantially free of lactose. The present invention is also directed to methods for treating diseases or conditions including Alzheimer's disease and/or Parkinson's disease, comprising administering to a patient in need thereof tablets regarding the same.Type: GrantFiled: January 16, 2019Date of Patent: April 13, 2021Assignee: Biotie Therapies, Inc.Inventors: Christopher G. Salentine, Thomas R. Malefyt
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Publication number: 20210093639Abstract: The present invention provides a controlled-release composition containing tozadenant, at least one cellulose ether, and one or more pharmaceutically acceptable excipients. In the composition, the tozadenant is present in an amount ranging from about 30% (w/w) to about 65% (w/w) based on the total composition weight; and the cellulose ether is present in an amount sufficient to provide: not less than about 10% and not more than about 30% tozadenant dissolution over a 2-hour test period, not less than about 55% tozadenant dissolution over a 10-hour test period, and not less than about 80% tozadenant dissolution over a 16-hour test period. Use of the composition for treatment of Parkinson's disease is also described.Type: ApplicationFiled: May 12, 2020Publication date: April 1, 2021Inventors: Thomas R. MALEFYT, Christopher G. SALENTINE, Mehdi PABORJI, Stephen I. BANDAK
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Patent number: 10653699Abstract: The present invention provides a controlled-release composition containing tozadenant, at least one cellulose ether, and one or more pharmaceutically acceptable excipients. In the composition, the tozadenant is present in an amount ranging from about 30% (w/w) to about 65% (w/w) based on the total composition weight; and the cellulose ether is present in an amount sufficient to provide: not less than about 10% and not more than about 30% tozadenant dissolution over a 2-hour test period, not less than about 55% tozadenant dissolution over a 10-hour test period, and not less than about 80% tozadenant dissolution over a 16-hour test period. Use of the composition for treatment of Parkinson's disease is also described.Type: GrantFiled: May 23, 2016Date of Patent: May 19, 2020Assignee: Biotie Therapies, Inc.Inventors: Thomas R. Malefyt, Christopher G. Salentine, Mehdi Paborji, Stephen I. Bandak
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Patent number: 10314798Abstract: The present invention is directed to tablets for oral administration to a subject, comprising a therapeutically effective amount of SYN120 or a pharmaceutically acceptable salt thereof, wherein the tablet is substantially free of lactose. The present invention is also directed to methods for treating diseases or conditions including Alzheimer's disease and/or Parkinson's disease, comprising administering to a patient in need thereof tablets regarding the same.Type: GrantFiled: September 29, 2017Date of Patent: June 11, 2019Assignee: Biotie Therapies, Inc.Inventors: Christopher G. Salentine, Thomas R. Malefyt
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Publication number: 20190142771Abstract: The present invention is directed to tablets for oral administration to a subject, comprising a therapeutically effective amount of SYN120 or a pharmaceutically acceptable salt thereof, wherein the tablet is substantially free of lactose. The present invention is also directed to methods for treating diseases or conditions including Alzheimer's disease and/or Parkinson's disease, comprising administering to a patient in need thereof tablets regarding the same.Type: ApplicationFiled: January 16, 2019Publication date: May 16, 2019Inventors: Christopher G. SALENTINE, Thomas R. MALEFYT
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Publication number: 20180303843Abstract: The present invention provides a controlled-release composition containing tozadenant, at least one cellulose ether, and one or more pharmaceutically acceptable excipients. In the composition, the tozadenant is present in an amount ranging from about 30% (w/w) to about 65% (w/w) based on the total composition weight; and the cellulose ether is present in an amount sufficient to provide: not less than about 10% and not more than about 30% tozadenant dissolution over a 2-hour test period, not less than about 55% tozadenant dissolution over a 10-hour test period, and not less than about 80% tozadenant dissolution over a 16-hour test period. Use of the composition for treatment of Parkinson's disease is also described.Type: ApplicationFiled: May 23, 2016Publication date: October 25, 2018Applicant: Biotie Therapies, Inc.Inventor: Thomas R. MALEFYT
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Publication number: 20180092868Abstract: The present invention is directed to tablets for oral administration to a subject, comprising a therapeutically effective amount of SYN120 or a pharmaceutically acceptable salt thereof, wherein the tablet is substantially free of lactose. The present invention is also directed to methods for treating diseases or conditions including Alzheimer's disease and/or Parkinson's disease, comprising administering to a patient in need thereof tablets regarding the same.Type: ApplicationFiled: September 29, 2017Publication date: April 5, 2018Applicant: Biotie Therapies, Inc.Inventors: Christopher G. SALENTINE, Thomas R. MALEFYT
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Patent number: 8735576Abstract: Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance.Type: GrantFiled: August 5, 2013Date of Patent: May 27, 2014Assignee: Biotie Therapies, Inc.Inventors: Thomas R. Malefyt, Lesley Pickford
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Publication number: 20130317219Abstract: Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance.Type: ApplicationFiled: August 5, 2013Publication date: November 28, 2013Applicant: Biotie Therapies, Inc.Inventors: Thomas R. Malefyt, Lesley Pickford
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Patent number: 8501938Abstract: Provided are compounds of formula I or II that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods oftreating patients suffering from or susceptible to at least one symptom of abuse of dependence on, or withdrawal from at least one substance.Type: GrantFiled: June 16, 2010Date of Patent: August 6, 2013Assignee: Biotie Therapies, Inc.Inventors: Thomas R. Malefyt, Leslie Pickford
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Patent number: 8212044Abstract: Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance.Type: GrantFiled: November 17, 2011Date of Patent: July 3, 2012Assignee: Biotie Therapies, Inc.Inventors: Thomas R. Malefyt, Lesley Pickford
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Patent number: 8168785Abstract: Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance.Type: GrantFiled: June 17, 2009Date of Patent: May 1, 2012Assignee: Biotie Therapies, Inc.Inventors: Thomas R. Malefyt, Lesley Pickford
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Publication number: 20120083604Abstract: Provided are compounds of formula I or II that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods oftreating patients suffering from or susceptible to at least one symptom of abuse of dependence on, or withdrawal from at least one substance.Type: ApplicationFiled: June 16, 2010Publication date: April 5, 2012Applicant: BIOTIE THERAPIES, INC.Inventors: Thomas R. Malefyt, Leslie Pickford
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Publication number: 20120065403Abstract: Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance.Type: ApplicationFiled: November 17, 2011Publication date: March 15, 2012Applicant: BIOTIE THERAPIES, INC.Inventors: Thomas R. Malefyt, Lesley Pickford
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Publication number: 20100324286Abstract: Provided are compounds and their pharmaceutically acceptable salts that are useful for the treatment of diseases related to the adenosine receptor. Also included are methods of treating patients suffering from or susceptible to at least one symptom of abuse of, dependence on, or withdrawal from at least one substance.Type: ApplicationFiled: June 17, 2009Publication date: December 23, 2010Applicant: SYNOSIA THERAPEUTICS, INC.Inventors: Thomas R. Malefyt, Lesley Pickford