Patents by Inventor Thomas R. Matthews

Thomas R. Matthews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkaloids of marine origin
    Patent number: 4959370
    Abstract: This invention is directed to novel compounds of Formula (I): ##STR1## wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof and pharmaceutical compositions formulated therewith. This invention is also directed to a method for treating helminthiasis and for inhibiting reverse transcriptase activity in an animal by the administration of compounds of Formula (I).
    Type: Grant
    Filed: March 29, 1989
    Date of Patent: September 25, 1990
    Inventors: Phillip Crews, Thomas R. Matthews, Wayne D. Inman
  • Anthelmintic dysinins of marine origin
    Patent number: 4943589
    Abstract: This invention is directed to a method for treating helminthiasis which comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of Formula (I): ##STR1## where R.sup.1 is hydrogen or --SR.sup.2,whereinR.sup.2 is hydrogen, --C(O)--CH.sub.3, or ##STR2## or a pharmaceutically acceptable salt thereof. This invention is also directed to a composition for treating helminthiasis in an animal which comprises a pharmaceutically acceptable excipient and an anthelmintically effective amount of a compound of Formula (I). This invention is also directed to novel compounds of Formula (I) wherein R.sup.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: July 24, 1990
    Assignees: Syntex (U.S.A.) Inc., The Regents of the Univ. of California
    Inventors: Phillip Crews, Thomas R. Matthews, Paul Horton
  • Gutter cleaner
    Patent number: 4930824
    Abstract: A gutter cleaner for remotely cleaning an overhead gutter or the like which includes an elongate handle, a pair of cooperating fork-like jaws mounted at the upper end of the handle, and a sleeve slidably mounted on the lower end of the handle for selectively opening and closing the fork-like jaws. The jaws include a stationary first jaw and a relatively pivotably movable second jaw which each have a greater width than height so that the jaws may be placed in a gutter extending in a direction lengthwise with the gutter. In this manner a substantial length of the gutter may be cleaned of collected debris with each application of the gutter cleaner thereto.
    Type: Grant
    Filed: April 28, 1989
    Date of Patent: June 5, 1990
    Assignee: Mercantile Enterprises, Inc.
    Inventors: Thomas R. Matthews, Garland B. Ricketts
  • Bengamide anthelmintics
    Patent number: 4831135
    Abstract: Novel .delta.-caprolactam derivatives of formula I have anti-tumor, antibiotic and anthelmintic activity: ##STR1## wherein: R is H, lower alkyl, or lower acyl;R.sub.1, R.sub.2, and R.sub.3 are each independently H or lower acyl;R.sub.4 is H or acyl of 1 to 22 carbon atoms;R.sub.5 is H or lower acyl;R.sub.6 and R.sub.7 are each H or OH, or R.sub.6 and R.sub.7 together form an epoxide or a double bond;and the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 18, 1986
    Date of Patent: May 16, 1989
    Assignees: The Regents of the University of California, Syntex (U.S.A.), Inc.
    Inventors: Philip Crews, Thomas R. Matthews, Emilio Quinoa, Madeline Adamczeski
  • Oxazole anthelmintic agents of marine origin
    Patent number: 4785012
    Abstract: New oxazole derivatives of formula 1 and their pharmacetically acceptable salts have anthelmintic activity: ##STR1## where R is H, OH, or acyloxy of 8 to 22 carbon atoms;R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each independently H or acyl of 1 to 6 carbon atoms.
    Type: Grant
    Filed: April 9, 1987
    Date of Patent: November 15, 1988
    Assignees: Syntex Corporation, The Regents of the University of California
    Inventors: Philip Crews, Thomas R. Matthews, Emilio Q. Cabana, Madeline Adamczeski
  • Method for enhancing the anti-infective activity of muramyldipeptide derivatives
    Patent number: 4684625
    Abstract: Co-administration of a muramyldipeptide derivative with liposomes enhances the anti-infective activity of the muramyldipeptide derivative.
    Type: Grant
    Filed: April 19, 1985
    Date of Patent: August 4, 1987
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Deborah A. Eppstein, Elizabeth Fraser-Smith, Thomas R. Matthews
  • Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
    Patent number: 4522811
    Abstract: Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides.
    Type: Grant
    Filed: July 8, 1982
    Date of Patent: June 11, 1985
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Deborah A. Eppstein, Elizabeth B. Fraser-Smith, Thomas R. Matthews