Abstract: A method of forming a polyethylene (PE) article, comprising optionally providing a first support, assembling a plurality of polyethylene substrates on the first support, the plurality of polyethylene substrates defining a PE construct, applying a second support to the PE construct such that the PE construct is positioned between the first support and the second support, positioning the first support, the PE construct, and the second support proximate a housing, and applying a force to the first support, the second support, and the PE construct such that the first support, the second support, and the PE construct expand to conform to the housing, wherein the housing limits distension of the first support, the second support, and the PE construct beyond the housing such that when the PE construct expands, an PE article is formed.

Abstract: An article comprising an expanded polyethylene substrate (12) having a longitudinal length, a first zone (14), and a second zone (16). The first zone having a first density and the second zone having a second density, the second density being greater than the first density, and the second zone is embossed.

Abstract: A method of densifying an expanded polyethylene (ePE) substrate, the method comprising providing an ePE substrate having a first density and a first size, selectively densifying a portion of the ePE substrate to form a densified portion of the ePE substrate, the densified portion of the ePE substrate having a second density that is greater than the first density, the densified portion of the ePE being a densified pattern, and shrinking the ePE substrate to a second size such that the densified pattern is reduced to a fine densified pattern, the second size being smaller than the first size, the fine densified patten being smaller than the densified pattern.

Abstract: A method of processing expanded polyethylene (ePE) comprising positioning an ePE substrate onto a heated component, the ePE substrate having a first size as the ePE substrate is heated on the heated component, removing the ePE substrate from the heated component such that the ePE substrate cools and retracts to second size, wherein the second size is smaller than the first size, and forming the ePE substrate into an ePE article.

Abstract: An expandable sheath is disclosed herein, which has a first polymeric layer and a braided layer positioned radially outward of the first polymeric layer. The braided layer includes a plurality of filaments braided together. The expandable sheaths further include a resilient elastic layer positioned radially outward of the braided layer. The elastic layer is configured to apply radial force to the braided layer and the first polymeric layer. The expandable sheath further includes a second polymeric layer positioned radially outward of the elastic layer and bonded to the first polymeric layer such that the braided layer and the elastic layer are encapsulated between the first and second polymeric layers. Methods of making and using the devices disclosed herein are also disclosed, as are crimping devices that may be used in methods of making the devices disclosed herein.

Abstract: A valve assembly comprising an outer tube, and an inner tube arranged at least partially within the outer tube member, the inner tube is formed of a compliant material and extending along a longitudinal axis between a first end and a second end, and a center portion located between the first and second ends, the center portion defining a center portion outer diameter, a first end ring defining a first end ring outer diameter, the first end ring being defined by a first segment of the inner tube adjacent the first end that has been fixed in a longitudinally compressed state to define the first end ring outer diameter, the first end ring outer diameter being greater than the center portion outer diameter.

Abstract: A device includes a plurality of elongate members, an occlusive component, and a support component. The occlusive component includes a plurality of first features each defined by a first portion of a respective elongate member. The support component includes a plurality of second features each defined by a second portion of the respective elongate member. A first termination element is defined by proximal end portions of the plurality of elongate members and located near a proximal end of the device, and a second termination element is defined by distal end portions of the plurality of elongate members and located near a distal end of the device. One or more anchor elements include a frame attachment portion and an anchor portion, the frame attachment portion including a first portion of a fixation elongate element wrapped around an elongate member, and the anchor portion including an anchor feature.

Abstract: An occlusive device includes a covering component configured to modulate passage of blood or thrombus therethrough, and an occlusion frame that includes a plurality of elongate occlusion frame members. The elongate occlusion frame members are arranged to form a generally disc-shaped member. The occlusion frame is at least partially covered by the covering component. The device further includes an anchor frame that includes a plurality of elongate anchor frame members. The device further includes a first hub component from which the elongate frame members extend, and a second hub component from which the elongate frame members extend.

Abstract: An occlusive device includes a covering component configured to modulate passage of blood or thrombus therethrough, and an occlusion frame that includes a plurality of elongate occlusion frame members. The elongate occlusion frame members are arranged to form a generally disc-shaped member. The occlusion frame is at least partially covered by the covering component. The device further includes an anchor frame that includes a plurality of elongate anchor frame members. The device further includes a first hub component from which the elongate frame members extend, and a second hub component from which the elongate frame members extend.

Abstract: A device includes a plurality of elongate members, an occlusive component, and a support component. The occlusive component includes a plurality of first features each defined by a first portion of a respective elongate member. The support component includes a plurality of second features each defined by a second portion of the respective elongate member. A first termination element is defined by proximal end portions of the plurality of elongate members and located near a proximal end of the device, and a second termination element is defined by distal end portions of the plurality of elongate members and located near a distal end of the device. One or more anchor elements include a frame attachment portion and an anchor portion, the frame attachment portion including a first portion of a fixation elongate element wrapped around an elongate member, and the anchor portion including an anchor feature.

Abstract: A device includes a plurality of elongate members, an occlusive component, and a support component. The occlusive component includes a plurality of first features each defined by a first portion of a respective elongate member. The support component includes a plurality of second features each defined by a second portion of the respective elongate member. A first termination element is defined by proximal end portions of the plurality of elongate members and located near a proximal end of the device, and a second termination element is defined by distal end portions of the plurality of elongate members and located near a distal end of the device. One or more anchor elements include a frame attachment portion and an anchor portion, the frame attachment portion including a first portion of a fixation elongate element wrapped around an elongate member, and the anchor portion including an anchor feature.

Abstract: An occlusive device includes a covering component configured to modulate passage of blood or thrombus therethrough, and an occlusion frame that includes a plurality of elongate occlusion frame members. The elongate occlusion frame members are arranged to form a generally disc-shaped member. The occlusion frame is at least partially covered by the covering component. The device further includes an anchor frame that includes a plurality of elongate anchor frame members. The device further includes a first hub component from which the elongate frame members extend, and a second hub component from which the elongate frame members extend.

Abstract: Deployment systems and methods are provided herein for percutaneous transcatheter deployment of medical devices. A medical device deployment system includes a body member and a body locking member that is configured to cooperatively engage along a portion of the body member such that the body member is releasably coupleable to a medical device.

Abstract: A device frame includes a plurality of elongate frame members, first and second hub members substantially aligned along a longitudinal axis of the device frame, and a coupling element that couples the first hub member to the second hub member. The device frame includes a face section, a laterally facing skirt section, and an inverted section. First portions of the elongate members define the face section and extend radially from the first hub member. Second portions of the elongate members define the laterally facing skirt section and extend in a distal, axial, and helical direction along a first rotational direction from the face section. Third portions of the elongate members define the inverted section and extend in a generally proximal direction from a distal portion of the laterally facing skirt section to the second hub member along a rotational direction opposite the first rotational direction.

Abstract: A medical device delivery system includes an implantable medical device and a delivery device. The implantable medical device includes at least one attachment feature having an elastomeric element. The delivery device includes a catheter and an elongate element. The catheter is arranged to contact the elastomeric element, and the elongate element is arranged to releasably couple with the elastomeric element.

Abstract: The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.

Abstract: The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.

Abstract: The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.

Abstract: A highly flexible implantable lead that offers improved flexibility, fatigue life and fatigue and abrasion resistance improved reliability, effective electrode tissue contact with a small diameter and low risk of tissue damage during extraction. In one embodiment the lead is provided with both defibrillation electrodes and pacing/sensing electrodes. For defibrillation/pacing leads, the lead diameter may be as small as six French or smaller. The construction utilizes helically wound conductors. For leads incorporating multiple separate conductors, many of the helically wound conductors are arranged in a multi-filar relationship. Preferably, each conductor is a length of wire that is uninsulated at about the middle of its length to create an electrode, wherein the conductor is folded in half at about the middle of the length to create first and second length segments that constitute parallel conductors.

Abstract: The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.