Patents by Inventor Thomas R. Unnasch

Thomas R. Unnasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Angiogenic Onchocerca volvulus proteins and uses thereof
    Patent number: 6723322
    Abstract: The present invention provides a method for inducing angiogenesis in a tissue, by contacting the tissue with an amount of Ov-ASP effective to induce angiogenesis in the tissue. The present invention further provides a method for screening for an anti-Ov-ASP factor, by contacting a factor of interest with Ov-ASP, and assessing the ability of the factor to inhibit angiogenic activity of Ov-ASP. Additionally, the present invention provides a method for inhibiting angiogenesis in a subject.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: April 20, 2004
    Assignees: New York Blood Center, Inc., Case Western Reservei University, UAB Research Foundation
    Inventors: Sara Lustigman, Eric Pearlman, Thomas R. Unnasch
  • Expression cDNA clones encoding antigens of onchocerca volvulus
    Patent number: 5021342
    Abstract: A cDNA clone (.lambda.RAL-1) that encodes a protein with an apparent molecular weight of 42,000 in vivo and which clone binds with O. volvulus antisera.A recombinant antigen produced by the aforementioned clone, which antigen stimulates T cells from infected individuals to proliferate.A DNA which codes for an O. volvulus peptide sequence, the sequence containing three repeats of the polypeptide sequence KKPEDWD.
    Type: Grant
    Filed: June 30, 1988
    Date of Patent: June 4, 1991
    Assignee: University Hospitals of Cleveland
    Inventors: Bruce M. Greene, Thomas R. Unnasch