Patents by Inventor Thomas Reh

Thomas Reh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8557972
    Abstract: The present invention provides reagents and methods for RNA transfection and protein expression.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: October 15, 2013
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Thomas A. Reh, Olivia M. Bermingham-McDonogh, Toshinori Hayashi
  • Publication number: 20110151557
    Abstract: The present invention provides reagents and methods for RNA transfection and protein expression
    Type: Application
    Filed: December 21, 2010
    Publication date: June 23, 2011
    Applicant: University of Washington
    Inventors: Thomas A. Reh, Olivia M. Bermingham-McDonogh, Toshinori Hayashi
  • Publication number: 20110044957
    Abstract: A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided.
    Type: Application
    Filed: August 23, 2010
    Publication date: February 24, 2011
    Applicant: University of Washington
    Inventors: Ryo KUBOTA, Thomas A. Reh, Andrew J. Fischer
  • Publication number: 20110004272
    Abstract: In one aspect, the invention provides vision prosthesis systems. Exemplary vision prosthesis systems of the invention comprise a light energy generator operably connected to a wearable head piece comprising a device for directing light energy produced by the light energy generator onto a mammalian retina, wherein the light energy generator is tuned to emit light energy of sufficient power to modulate neural activity in the retina. In another aspect, the invention provides methods for irradiating neurons in the retina of the mammalian eye by directing light energy produced by a light energy generator onto a mammalian retina. The methods of the invention may be used to directly modulate the activity of retinal neurons or to introduce molecules into retinal cells.
    Type: Application
    Filed: November 8, 2007
    Publication date: January 6, 2011
    Applicant: WASHINGTON, UNIVERSITY OF
    Inventors: Eric J. Seibel, Thomas A. Reh, Blake Miller
  • Patent number: 7541186
    Abstract: Methods are provided for the in vitro differentiation of human retinal progenitor cells from embryonic stem cells.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: June 2, 2009
    Assignee: University of Washington
    Inventors: Thomas Reh, Deepak Lamba
  • Publication number: 20080175826
    Abstract: A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided.
    Type: Application
    Filed: November 16, 2007
    Publication date: July 24, 2008
    Applicant: University of Washington
    Inventors: Ryo Kubota, Thomas A. Reh, Andrew J. Fischer
  • Patent number: 7312025
    Abstract: A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: December 25, 2007
    Assignee: University of Washington
    Inventors: Ryo Kubota, Thomas A Reh, Andrew J Fischer
  • Patent number: 7311723
    Abstract: In one aspect, the invention provides vision prosthesis systems. Exemplary vision prosthesis systems of the invention comprise a light energy generator operably connected to a wearable head piece comprising a device for directing light energy produced by the light energy generator onto a mammalian retina, wherein the light energy generator is tuned to emit light energy of sufficient power to modulate neural activity in the retina. In another aspect, the invention provides methods for irradiating neurons in the retina of the mammalian eye by directing light energy produced by a light energy generator onto a mammalian retina. The methods of the invention may be used to directly modulate the activity of retinal neurons or to introduce molecules into retinal cells.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: December 25, 2007
    Assignee: University of Washington
    Inventors: Eric J. Seibel, Thomas A. Reh, Blake Miller
  • Publication number: 20070196919
    Abstract: Methods are provided for the in vitro differentiation of human retinal progenitor cells from embryonic stem cells.
    Type: Application
    Filed: February 22, 2006
    Publication date: August 23, 2007
    Inventors: Thomas Reh, Deepak Lamba
  • Publication number: 20050015120
    Abstract: In one aspect, the invention provides vision prosthesis systems. Exemplary vision prosthesis systems of the invention comprise a light energy generator operably connected to a wearable head piece comprising a device for directing light energy produced by the light energy generator onto a mammalian retina, wherein the light energy generator is tuned to emit light energy of sufficient power to modulate neural activity in the retina. In another aspect, the invention provides methods for irradiating neurons in the retina of the mammalian eye by directing light energy produced by a light energy generator onto a mammalian retina. The methods of the invention may be used to directly modulate the activity of retinal neurons or to introduce molecules into retinal cells.
    Type: Application
    Filed: July 9, 2004
    Publication date: January 20, 2005
    Inventors: Eric Seibel, Thomas Reh, Blake Miller
  • Publication number: 20040234500
    Abstract: The present invention relates to a method for promoting the proliferation of retinal stem cells using IL-17B. IL-17B is put into a cell culture medium containing retinal stem cells to promote the proliferation and/or differentiation of retinal stem cells. The retinal stem cells can then be transplanted into the retina to promote the growth of the photoreceptor cells, the rods and the cones. Also IL-17B can be administered directly into the retina to promote the proliferation and/or differentiation of the retinal stem cells.
    Type: Application
    Filed: May 3, 2004
    Publication date: November 25, 2004
    Inventors: Emma E. Moore, Thomas Reh
  • Publication number: 20040147019
    Abstract: A cell culture system related to extended in vitro culture of mature neuronal cells and methods for preparing the cell culture system are provided. In a preferred embodiment the invention provides a cell culture system comprising a mixture of mature neuronal retinal cells and cells isolated from a ciliary body. Methods for identifying bioactive agents that alter neurodegeneration of neuronal retinal cells are also provided.
    Type: Application
    Filed: July 11, 2003
    Publication date: July 29, 2004
    Applicant: University of Washington
    Inventors: Ryo Kubota, Thomas A. Reh, Andrew J. Fischer
  • Patent number: 6750196
    Abstract: In general, the present invention provides methods for promoting the function of retinal cells using neuregulins. A novel aspect of the invention involves the use of neuregulins as growth factors tp promote survival of retinal cells. Treating of the retinal cells to provide these effects may be achieved by contacting retinal cells with a polypeptide described herein. The treatments may be provided to slow or halt net cell loss or to increase the amount or quality of retinal tissue present in the vertebrate.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: June 15, 2004
    Assignee: Acorda Therapeutics
    Inventors: Thomas A. Reh, Mark A. Marchionni, Kathryn L. McCabe, Olivia Bermingham-McDonogh, Nagesh K. Mahanthappa, David I. Gwynne