Abstract: The present invention provides methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators, and compositions having low impurity levels.

Abstract: An expandable introducer includes a hub and a tubular sheath (121) coupled thereto. The tubular sheath (121) defines a central lumen (103). A circumference of the tubular sheath includes a full thickness region (162) having a first wall thickness (T2) and a reduced thickness region (161) having a second wall thickness (T1) smaller than the first wall thickness (T2). The reduced thickness region (162) is configured to be folded such that the tubular sheath includes an unexpanded, folded state and is configured to expand to an expanded, unfolded state in response to a device passing though the central lumen (103). A first outer diameter of the tubular sheath in the unexpanded, folded state is smaller than a second outer diameter of the tubular sheath in the expanded, unfolded state.

Abstract: A multiport passive photonic light circuit chip has multiple waveguides written in at least two layers on a glass substrate. Some waveguides connect transmitting and receiving ports of an optical channel, some waveguides redirect a fraction of optical signals to some other receiving ports, and waveguides have circular cross-sectional shapes wherein a refractive index contrast is in the range of 0.2% to 2%.

Abstract: A coupled valve assembly comprises two valves disposed within separate housings and connected with a common coupling, such that a single actuator causes rotation of the valve stems within both valves. The two valves are configured 90 degrees out of phase with each other, such that the actuator will cause one valve to open at the same time it causes the other valve to close. The coupled valve assembly may be used to selectively divert the flow of production fluids from a wellbore to either a production header or a test header within a production manifold.

Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

Abstract: A dishwasher having a detergent dispenser including an opening allowing the insertion of dishwashing detergent into the dispenser without needing to open the dispenser. The detergent dispenser includes a housing including a tray for holding the inserted detergent and the housing includes a siphon component having a cap and an outlet tube. A delivery tube provides water via one or more nozzles via the opening during operation of the dishwasher. Dissolved detergent is siphoned from the housing via the outlet tube and into the tub.

Abstract: An insulation system and method are disclosed for insulating formed coils of electrical machines, such as motors and generators. The system includes strand/turn insulation that may include one or more layers of different materials, depending upon the dielectric requirements. A ground wall insulation is applied over the group of turns. The coil may be sized in a slot cell section. Additional insulation layers are provided, including a slot corona suppression insulation that extends just beyond stator slots, a voltage grading layer, and an armor layer. The resulting system is highly adaptable to different machine designs and ratings, and affords superior resistance to degradation.

Abstract: A lift device includes a first rail guide coupled vertically to a support wall, a rail coupled to the first rail guide, and a carrier plate coupled to the rail by at least one linear bearing rail block coupled to the carrier plate and the rail. The at least one linear bearing rail block is configured to move along a length of the rail. The lift device further includes a threaded drive shaft extending parallel to the first rail guide, through the carrier plate, and coupled to the carrier plate at a top edge and a bottom edge of the carrier plate, and a drive motor coupled with the drive shaft, wherein the drive motor drives movement of the carrier plate along the drive shaft. The lift device may further include a rotating mechanism configured to move the cylindrical cartridge from a first orientation to a second orientation.

Abstract: An automated bioprocess solution preparation apparatus includes a first mixing chamber containing at least one ingredient for a bioprocess solution, a first port and a second port for a fluid to enter the mixing chamber, and a third port for a liquid bioprocess solution to exit the mixing chamber. The apparatus further includes an array of tubing for fluid flow within the apparatus, a sensor arranged to measure a property of the liquid bioprocess solution exiting the mixing chamber, a first valve associated with the first port, and a second valve associated with the second port. When the property meets or exceeds a threshold value, the apparatus is operable to perform at least one of: closing the first valve to block the fluid from entering the mixing chamber through the first port, and opening the second valve for the fluid to enter the mixing chamber through the second port.

Abstract: An insulation system and method are disclosed for insulating formed coils of electrical machines, such as motors and generators. The system includes strand/turn insulation that may include one or more layers of different materials, depending upon the dielectric requirements. A ground wall insulation is applied over the group of turns. The coil may be sized in a slot cell section. Additional insulation layers are provided, including a slot corona suppression insulation that extends just beyond stator slots, a voltage grading layer, and an armor layer. The resulting system is highly adaptable to different machine designs and ratings, and affords superior resistance to degradation.

Abstract: An automated apparatus for preparing a liquid bioprocess solution includes at least one mixing chamber having a lower port and an upper port for fluid to enter the at least one mixing chamber, an array of tubing for fluid flow within the system, a plurality of valves provided within the tubing, and a mixing controller configured to cause the automated apparatus to perform a series of sequential mixing steps causing the preparation of the liquid bioprocess solution from a dry ingredient. The series of sequential mixing steps include opening a first valve associated with the lower port to provide fluid to the at least one mixing chamber through the lower port, and after a predetermined amount of elapsed time, closing the first valve and opening a second valve associated with the upper port to provide fluid to the at least one mixing chamber through the upper port.

Abstract: Devices and methods for performing a skin biopsy are discussed herein. The skin biopsy device provides for consistent depth and shape, such as by reducing or eliminating operator error or inter-operator variability by generating the same forces across multiple uses. The skin biopsy device can also eliminate puckering of wound closures by incorporating a fusiform blade (e.g., elliptical blade or a diamond-shaped blade). The skin biopsy device includes a casing, a firing pin, a retaining rod, and a blade. The retaining rod holds the blade or can attach to a punch biopsy. The firing pin generates and impacts the retaining rod with a force necessary to drive the blade a given depth into a target tissue to obtain a biological sample.

Abstract: A filter unit for a mixing apparatus includes a hydrophilic filter and a hydrophobic vent filter. The hydrophilic filter is configured to receive a fluid including a liquid and gas. The hydrophilic filter is further configured to sterilize the liquid. The hydrophobic vent filter is configured to receive the gas from the hydrophilic filter. The hydrophobic vent filter further includes a vent and a membrane configured to separate an interior of the filter unit from an exterior of the filter unit, the gas being vented from the filter unit by flowing across the membrane and out of the vent. In some embodiments, the filter unit further includes a defoaming device configured to receive gas, foam comprised the liquid containing trapped gas, and some of the liquid from the hydrophilic filter and is further configured to release at least some of the gas from the foam.

Abstract: In some embodiments, the present disclosure provides an exemplary method that may include the steps of providing a computing device associated with a plurality of user; receiving output data transmitted from a target unit; analyzing the output data; transmitting a plurality of interaction commands; transmitting the plurality of interaction commands to an application or operating system; determining a plurality of identifying key words; dynamically determining a configuration screen image based on an identification of the plurality of identifying key words associated with the plurality of graphical user interface displays; automatically selecting a configuration setting associated with the plurality of interactive image elements based on the configurations screen image; and executing a plurality of ameliorative actions associated with the configuration setting.

Abstract: Devices and methods for performing a skin biopsy are discussed herein. The skin biopsy device provides for consistent depth and shape, such as by reducing or eliminating operator error or inter-operator variability by generating the same forces across multiple uses. The skin biopsy device can also eliminate puckering of wound closures by incorporating a fusiform blade (e.g., elliptical blade or a diamond-shaped blade). The skin biopsy device includes a casing, a firing pin, a retaining rod, and a blade. The retaining rod holds the blade or can attach to a punch biopsy. The firing pin generates and impacts the retaining rod with a force necessary to drive the blade a given depth into a target tissue to obtain a biological sample.

Abstract: A filter unit for a mixing apparatus includes a hydrophilic filter and a hydrophobic vent filter. The hydrophilic filter is configured to receive a fluid including a liquid and gas. The hydrophilic filter is further configured to sterilize the liquid. The hydrophobic vent filter is configured to receive the gas from the hydrophilic filter. The hydrophobic vent filter further includes a vent and a membrane configured to separate an interior of the filter unit from an exterior of the filter unit, the gas being vented from the filter unit by flowing across the membrane and out of the vent. In some embodiments, the filter unit further includes a defoaming device configured to receive gas, foam comprised the liquid containing trapped gas, and some of the liquid from the hydrophilic filter and is further configured to release at least some of the gas from the foam.

Abstract: In some embodiments, the present disclosure provides an exemplary method that may include the steps of providing a computing device associated with a plurality of user; receiving output data transmitted from a target unit; analyzing the output data; transmitting a plurality of interaction commands; transmitting the plurality of interaction commands to an application or operating system; determining a plurality of identifying key words; dynamically determining a configuration screen image based on an identification of the plurality of identifying key words associated with the plurality of graphical user interface displays; automatically selecting a configuration setting associated with the plurality of interactive image elements based on the configurations screen image; and executing a plurality of ameliorative actions associated with the configuration setting.

Abstract: In some embodiments, the present disclosure provides an exemplary method that may include the steps of providing a computing device associated with a plurality of user; receiving output data transmitted from a target unit; analyzing the output data; transmitting a plurality of interaction commands; transmitting the plurality of interaction commands to an application or operating system; determining a plurality of identifying key words; dynamically determining a configuration screen image based on an identification of the plurality of identifying key words associated with the plurality of graphical user interface displays; automatically selecting a configuration setting associated with the plurality of interactive image elements based on the configurations screen image; and executing a plurality of ameliorative actions associated with the configuration setting.

Abstract: An automated apparatus for preparing a liquid bioprocess solution includes at least one mixing chamber having a lower port and an upper port for fluid to enter the at least one mixing chamber, an array of tubing for fluid flow within the system, a plurality of valves provided within the tubing, and a mixing controller configured to cause the automated apparatus to perform a series of sequential mixing steps causing the preparation of the liquid bioprocess solution from a dry ingredient. The series of sequential mixing steps include opening a first valve associated with the lower port to provide fluid to the at least one mixing chamber through the lower port, and after a predetermined amount of elapsed time, closing the first valve and opening a second valve associated with the upper port to provide fluid to the at least one mixing chamber through the upper port.

Abstract: A filter unit for a mixing apparatus includes a hydrophilic filter and a hydrophobic vent filter. The hydrophilic filter is configured to receive a fluid including a liquid and gas. The hydrophilic filter is further configured to sterilize the liquid. The hydrophobic vent filter is configured to receive the gas from the hydrophilic filter. The hydrophobic vent filter further includes a vent and a membrane configured to separate an interior of the filter unit from an exterior of the filter unit, the gas being vented from the filter unit by flowing across the membrane and out of the vent. In some embodiments, the filter unit further includes a defoaming device configured to receive gas, foam comprised the liquid containing trapped gas, and some of the liquid from the hydrophilic filter and is further configured to release at least some of the gas from the foam.