Patents by Inventor Thomas Reppen

Thomas Reppen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REGULATABLE OR CONDITIONAL EXPRESSION SYSTEMS
    Publication number: 20070054872
    Abstract: Endogenous gene regulation mechanisms together with microRNAs expressed in many organisms can be used to provide regulated or conditional expression of transgenes by placing an appropriate sequence, a microRNA binding site, within the transcribed gene. This microRNA-dependent transcription regulation can be further regulated using microRNA inhibitors.
    Type: Application
    Filed: August 24, 2006
    Publication date: March 8, 2007
    Applicant: Mirus Bio Corporation
    Inventors: Thomas Reppen, David Lewis
  • Monitoring microrna expression and function
    Publication number: 20060265771
    Abstract: In vivo endogenous microRNA (miRNA) activity can be observed over time using miRNA sensor plasmids capable of long term expression. Using reporter genes whose expression can be monitored without sacrificing the animal enables the investigator to follow changes in miRNA expression though developmental stages or in response to environmental factors or treatment regimens.
    Type: Application
    Filed: April 26, 2006
    Publication date: November 23, 2006
    Inventors: David Lewis, Thomas Reppen, Paula Roesch