Abstract: The present invention is predicated upon the fact that an emission trace from a plasma glow used in fabricating integrated circuits contains information about phenoma which cause variations in the fabrication process such as age of the plasma reactor, densities of the wafers exposed to the plasma, chemistry of the plasma, and concentration of the remaining material. In accordance with the present invention, a method for using neural networks to determine plasma etch end-point times in an integrated circuit fabrication process is disclosed. The end-point time is based on in-situ monitoring of the optical emission trace. The back-propagation method is used to train the network. More generally, a neural network can be used to regulate control variables and materials in a manufacturing process to yield an output product with desired quality attributes. An identified process signature which reflects the relation between the quality attribute and the process may be used to train the neural network.