Abstract: The present invention relates to a novel method for the treatment and/or prophylaxis of a tau-mediated neurodegenerative disease and/or of a tau-mediated neurodegenerative pathological condition, especially of a neurodegenerative disease and/or of a neurodegenerative pathological condition associated with and/or accompanied by tau aggregation, and in particular for the treatment and/or prophylaxis of a tauopathy; compounds and/or agents and compositions for such treatment and/or prophylaxis, and the manufacture of the compounds and/or agents and compositions suitable for the said treatment and/or prophylaxis. In this regard, the present invention relates especially to the use of compounds acting as PERK activator, a prodrug thereof, a derivative thereof and/or a pharmaceutically acceptable salt of any thereof, as a medicament.

Abstract: The present invention relates to a novel method for the treatment and/or prophylaxis of a tau-mediated neurodegenerative disease and/or of a tau-mediated neurodegenerative pathological condition, especially of a neurodegenerative disease and/or of a neurodegenerative pathological condition associated with and/or accompanied by tau aggregation, and in particular for the treatment and/or prophylaxis of a tauopathy; compounds and/or agents and compositions for such treatment and/or prophylaxis, and the manufacture of the compounds and/or agents and compositions suitable for the said treatment and/or prophylaxis. In this regard, the present invention relates especially to the use of compounds acting as PERK activator, a prodrug thereof, a derivative thereof and/or a pharmaceutically acceptable salt of any thereof, as a medicament.

Abstract: A bearing arrangement (4) is provided with a bearing inner bush (10) and an outer bush (5), especially for the central joint (1) of a Watt's linkage. The bearing arrangement (4) is provided with a sealing arrangement (12) surrounding the front-side bearing gap between the inner bush (10) and the outer bush (5). The sealing arrangement (12) comprises an elastic sealing element (14) with static as well as dynamic sealing surfaces. The bearing arrangement (4) has a sealing arrangement (12) designed as a sealing module (12), which can be connected to the bearing inner bush (10), the sealing module (12) also comprising a running surface (15) for the axial bearing of the outer bush (5). The arrangement makes possible the especially economical production of modularly designed, highly loadable bush bearings. Furthermore, undivided, continuous bearing bushes can be used, which improves the ability to be mounted and the precision and the service life of the bearing arrangement.

Abstract: A ball and socket joint (1) is provided, for example, for a chassis bearing, with a ball (2), a pivot (3) originating from the ball (2), a housing (4) accommodating the ball, and a sealing bellows (5), which extends between the housing (4) and the pivot (3) and has a housing-side opening (6) and a pivot-side opening (7). The sealing bellows (5) has a circumferential sealing lip (8) for sealing at the pivot-side opening (7). The ball and socket joint (1) has a first guide ring (9), which guides the sealing bellows (5). The first guide ring (9) is arranged at the pivot (3). An especially favorable functional separation is achieved as a result between the guiding function and the sealing function.