Abstract: Methods of preventing or treating an immune-mediated hair-loss disorder such as alopecia areata in a mammalian subject include administering an inhibitor of TYK2 to the mammalian subject. TYK2 inhibitors useful in such methods include a compound having the structure of Formula (I) as set forth herein, and a compound having the structure of Formula (II) as set forth herein.

Abstract: An active agent for use in hair growth regulation, particularly for use in the treatment of hair growth (stimulation or inhibition), wherein the active agent activates, enhances, inactivates, blocks or dampens the cellular response of the taste receptor TAS2R4 or interferes with the expression of the receptor. Furthermore, the present invention is directed to compositions for use as a cosmetic or medicament in the treatment of hair growth the composition comprising at least one of the aforementioned active agents and at least one auxiliary agent. In addition, a non-therapeutic method of hair growth regulation is disclosed, wherein an effective amount of at least one of the aforementioned active agents is administered to a subject.