Patents by Inventor Thomas Sandal

Thomas Sandal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ADIPOSE-DERIVED REGENERATIVE CELL PREPARATIONS
    Publication number: 20260139227
    Abstract: The present disclosure relates to adipose-derived regenerative cell (ADRC) preparations and methods of culturing ADRCs to obtain ASCs. In particular the present disclosure relates to adipose-derived stromal cells derived from these cultures and their use in treatment.
    Type: Application
    Filed: January 6, 2026
    Publication date: May 21, 2026
    Inventors: Gitte Lund Christensen, Visnja Radulovic, Elena Pedraz-Cuesta, Maja Lind Nybo, Benjamin Claass, Jone Marita Kvam, Søren Paludan Sheikh, Jakob Lerche Hansen, Thomas Sandal, Reza Yarani
  • MODIFIED PROTEINS AND PEPTIDES
    Publication number: 20250136721
    Abstract: The present invention relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g. fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains e.g. human immunoglobulin (antibody) single variable domains, and also single variable domains derived from non-human sources such as a llama or camel, e.g. a VHH including a nanobody TM (described in e.g. WO 94/04678 and WO 95/04079 inter alia). The invention further relates to uses, formulations, compositions comprising such modified C terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these molecules.
    Type: Application
    Filed: September 23, 2024
    Publication date: May 1, 2025
    Inventors: Claire Ashman, Mary Birchler, Rudolf M.T. De Wildt, Claire Holland, Alan Peter Lewis, Peter Morley, Thomas Sandal, Michael Steward
  • Compositions for treatment of disorders
    Patent number: 12134643
    Abstract: The invention relates to stable and non-aggregating compositions comprising an IL-17A binding molecule, in particular a single domain antibody. Such compositions are useful for topical administration in the treatment of disease, for example skin disease or asthma.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: November 5, 2024
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Karen Bannister, Ulla Lashmar, Daniel Pettit, Thomas Sandal
  • IL-17A BINDING PROTEINS
    Publication number: 20240199731
    Abstract: Binding molecules to IL-17A. The binding molecules are useful in the treatment of disorders, for example psoriasis.
    Type: Application
    Filed: April 26, 2023
    Publication date: June 20, 2024
    Inventors: Bryan Edwards, Ulla Lashmar, Brian McGuinness, Mike Romanos, Thomas Sandal, Yumin Teng
  • THERAPEUTIC MOLECULES
    Publication number: 20230406954
    Abstract: The invention relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Application
    Filed: June 28, 2023
    Publication date: December 21, 2023
    Inventors: Brian McGuinness, Isabelle Osuch, Chris Rossant, Mike Romanos, Nikki Royle, Thomas Sandal, Lorraine Thompson, Michele Writer
  • Therapeutic molecules
    Patent number: 11746158
    Abstract: The invention relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: September 5, 2023
    Assignee: Crescendo Biologics Limited
    Inventors: Brian McGuinness, Isabelle Osuch, Chris Rossant, Mike Romanos, Nikki Royle, Thomas Sandal, Lorraine Thompson, Michele Writer
  • IL-17A binding proteins
    Patent number: 11667705
    Abstract: Binding molecules to IL-17A. The binding molecules are useful in the treatment of disorders, for example psoriasis.
    Type: Grant
    Filed: April 8, 2020
    Date of Patent: June 6, 2023
    Assignee: Crescendo Biologics Limited
    Inventors: Bryan Edwards, Ulla Lashmar, Brian McGuinness, Mike Romanos, Thomas Sandal, Yumin Teng
  • Therapeutic Molecules
    Publication number: 20220112305
    Abstract: The invention relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Application
    Filed: October 22, 2021
    Publication date: April 14, 2022
    Inventors: Brian McGuinness, Isabelle Osuch, Chris Rossant, Mike Romanos, Nikki Royle, Thomas Sandal, Lorraine Thompson, Michele Writer
  • Therapeutic molecules
    Patent number: 11236174
    Abstract: The invention relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: February 1, 2022
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Brian McGuinness, Isabelle Osuch, Chris Rossant, Mike Romanos, Nikki Royle, Thomas Sandal, Lorraine Thompson, Michele Writer
  • COMPOSITIONS FOR TREATMENT OF DISORDERS
    Publication number: 20210261655
    Abstract: The invention relates to stable and non-aggregating compositions comprising an IL-17A binding molecule, in particular a single domain antibody. Such compositions are useful for topical administration in the treatment of disease, for example skin disease or asthma.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 26, 2021
    Inventors: Karen Bannister, Ulla Lashmar, Daniel Pettit, Thomas Sandal
  • Molecules that bind prostate specific membrane antigen (PSMA)
    Patent number: 10975161
    Abstract: The disclosure relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: April 13, 2021
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Eleanora Balloi, Normann Goodwin, Brian McGuinness, Chris Rossant, Thomas Sandal, Lorraine Thompson
  • Composition for treatment of disorders
    Patent number: 10947308
    Abstract: The invention relates to stable and non-aggregating compositions comprising an IL-17A binding molecule, in particular a single domain antibody. Such compositions are useful for topical administration in the treatment of disease, for example skin disease or asthma.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: March 16, 2021
    Assignee: Crescendo Biologics Limited
    Inventors: Karen Bannister, Ulla Lashmar, Daniel Pettit, Thomas Sandal
  • MODIFIED PROTEINS AND PEPTIDES
    Publication number: 20210017293
    Abstract: The present invention relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g. fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains e.g. human immunoglobulin (antibody) single variable domains, and also single variable domains derived from non-human sources such as a llama or camel, e.g. a VHH including a Nanobody™ (described in e.g. WO 94/04678 and WO 95/04079 inter alia). The invention further relates to uses, formulations, compositions comprising such modified C terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these molecules.
    Type: Application
    Filed: September 8, 2020
    Publication date: January 21, 2021
    Inventors: Claire Ashman, Mary Birchler, Rudolf M.T. De Wildt, Claire Holland, Alan Peter Lewis, Peter Morley, Thomas Sandal, Michael Steward
  • Molecules that Bind Prostate Specific Membrane Antigen (PSMA)
    Publication number: 20200392244
    Abstract: The invention relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Application
    Filed: January 12, 2017
    Publication date: December 17, 2020
    Inventors: Eleanora Balloi, Normann Goodwin, Brian McGuinness, Chris Rossant, Thomas Sandal, Lorraine Thompson, Michele Writer
  • IL-17A BINDING PROTEINS
    Publication number: 20200347127
    Abstract: Binding molecules to IL-17A. The binding molecules are useful in the treatment of disorders, for example psoriasis.
    Type: Application
    Filed: April 8, 2020
    Publication date: November 5, 2020
    Inventors: Bryan Edwards, Ulla Lashmar, Brian McGuinness, Mike Romanos, Thomas Sandal, Yumin Teng
  • Modified proteins and peptides
    Patent number: 10808040
    Abstract: The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: October 20, 2020
    Assignee: Glaxo Group Limited
    Inventors: Claire Ashman, Mary Birchler, Rudolf M. T. De Wildt, Claire Holland, Alan Peter Lewis, Peter Morley, Thomas Sandal, Michael Steward
  • IL-17A binding proteins
    Patent number: 10654924
    Abstract: Binding molecules to IL-17A. The binding molecules are useful in the treatment of disorders, for example psoriasis.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: May 19, 2020
    Assignee: CRESCENDO BIOLOGICS LIMITED
    Inventors: Bryan Edwards, Ulla Lashmar, Brian McGuinness, Mike Romanos, Thomas Sandal, Yumin Teng
  • Composition for Treatment of Disorders
    Publication number: 20190300603
    Abstract: The invention relates to stable and non-aggregating compositions comprising an IL-17A binding molecule, in particular a single domain antibody. Such compositions are useful for topical administration in the treatment of disease, for example skin disease or asthma.
    Type: Application
    Filed: July 10, 2017
    Publication date: October 3, 2019
    Inventors: Karen Bannister, Ulla Lashmar, Daniel Pettit, Thomas Sandal
  • Molecules that Bind Prostate Specific Membrane Antigen (PSMA)
    Publication number: 20190023807
    Abstract: The disclosure relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
    Type: Application
    Filed: January 12, 2017
    Publication date: January 24, 2019
    Inventors: Eleanora Balloi, Normann Goodwin, Brian McGuinness, Chris Rossat, Thomas Sandal, Lorraine Thompson
  • ANTI-IL-17RA IMMUNOGLOBULIN SINGLE HEAVY VARIABLE DOMAIN ANTIBODIES
    Publication number: 20180215829
    Abstract: Binding molecules that bind specifically to IL-17RA. The binding molecules are useful in the treatment of disease, for example psoriasis.
    Type: Application
    Filed: January 12, 2016
    Publication date: August 2, 2018
    Inventors: Bryan EDWARDS, Ulla LASHMAR, Brian MCGUINNESS, Mike ROMANOS, Thomas SANDAL, Joyce Young