Patents by Inventor Thomas Scheper

Thomas Scheper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240294607
    Abstract: The present invention relates to isolated, recombinant polypeptides comprising the gamma chain of fibrinogen and a His-Tag. The present invention further relates to nucleic acids encoding said polypeptides, vectors comprising said nucleic acids, host cells, preferably bacterial host cells, comprising said nucleic acids or vectors, biohybrid materials comprising conjugates comprising said polypeptides, uses of the above, and methods for producing said polypeptides.
    Type: Application
    Filed: May 20, 2021
    Publication date: September 5, 2024
    Inventors: Thomas SCHEPER, Iliyana PELANOVA, Pia GELLERMANN, Sabrina GRÜNERT
  • Patent number: 10914737
    Abstract: The invention relates to a device and a method for automated evaluation of incubated immunoblot strips (5). What is essential for such immunoblot strips (5) is that these have regions coated with antigens, which regions discolour under the formation of so-called bands (6) as soon as a binding occurs, in particular between the antigen and an antibody present in a patient sample. Within the scope of the described technical solution, a camera (2) is initially used to make recordings of the surface of an incubated immunoblot strip (5) and these recordings are transmitted in digitized form to an evaluation unit (1). Finally, the discolourings, which occurred in the form of bands (6), are detected and at least partly quantified in the evaluation unit (1), such that a diagnosis suggestion is generated taking into account the number of bands (6) and the colour strength thereof.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: February 9, 2021
    Assignee: EUROIMMUN Medizinische Labordiagnostika AG
    Inventors: Wolfgang Meyer, Thomas Scheper, Robert Kaffka
  • Patent number: 10802024
    Abstract: A method for diagnosing a limbic encephalitis, PNS, encephaloymyelitis, leukoencephalopathy, retinitis or optic atrophy, includes detecting a bornavirus in a sample, preferably from the group comprising mammalian 2 bornavirus, even more preferably VSBV-1, and mammalian 1 bornavirus, even more preferably BoDV-1; to a carrier containing a means for the capture of an antibody against at least one polypeptide selected from the group of BoDV-1-N, BoDV-1-P, VSBV-N and VSBV-P. A kit contains the carrier and a means for the detection of a captured antibody and a control for the detection of the presence of a sample. The carrier or kit or of a primer can be used for the detection of a bornavirus or a probe can be used for the diagnosis of an encephalitis, for the prognostication of post-transplantation complications, for the monitoring of a therapy of an encephalitis or of post-transplantation complications or for the differentiation between an autoimmune encephalitis and an encephalitis caused by infection.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 13, 2020
    Assignee: EUROIMMUN Medizinische Labordiagnostika AG
    Inventors: Erik Lattwein, Wolfgang Meyer, Wolfgang Schlumberger, Julia Janz, Anthonina Ott, Thomas Scheper, Jonas Schmidt-Chanasit, Dennis Tappe
  • Patent number: 10620191
    Abstract: A device for incubating an immunoblot strip (6) includes at least one incubation channel (1) into which an elongate immunoblot strip (6) having at least one biological material on its front is inserted with its back facing a channel base (2). An agitating means (7), with which the immunoblot strip (6) is agitatable around a transverse axis (8) of the strip (6) at least at times during incubation via an agitating device (7). For handling and/or grouping incubation channels (1) with immunoblot strips (6) inserted, a rack (3) for taking up at least two incubation channels (1) is provided. The rack (3) is in operative connection with said agitating means (7) via load transmission points.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: April 14, 2020
    Assignee: Euroimmun Medizinische Labordiagnostika AG
    Inventors: Winfried Stöcker, Wolfgang Meyer, Thomas Scheper, Antje Euken
  • Publication number: 20190204318
    Abstract: A method for diagnosing a limbic encephalitis, PNS, encephaloymyelitis, leukoencephalopathy, retinitis or optic atrophy, includes detecting a bornavirus in a sample, preferably from the group comprising mammalian 2 bornavirus, even more preferably VSBV-1, and mammalian 1 bornavirus, even more preferably BoDV-1; to a carrier containing a means for the capture of an antibody against at least one polypeptide selected from the group of BoDV-1-N, BoDV-1-P, VSBV-N and VSBV-P. A kit contains the carrier and a means for the detection of a captured antibody and a control for the detection of the presence of a sample. The carrier or kit or of a primer can be used for the detection of a bornavirus or a probe can be used for the diagnosis of an encephalitis, for the prognostication of post-transplantation complications, for the monitoring of a therapy of an encephalitis or of post-transplantation complications or for the differentiation between an autoimmune encephalitis and an encephalitis caused by infection.
    Type: Application
    Filed: December 20, 2018
    Publication date: July 4, 2019
    Applicant: EUROIMMUN Medizinische Labordiagnostika AG
    Inventors: Erik LATTWEIN, Wolfgang Meyer, Wolfgang Schlumberger, Julia Janz, Anthonina Ott, Thomas Scheper, Jonas Schmidt-Chanasit, Dennis Tappe
  • Patent number: 9891230
    Abstract: The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: February 13, 2018
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Dieter Melzner, Thomas Scheper, Thomas Schueler, Frank Stahl, Denise Van Rossum, Johanna-Gabriela Walter, Carsten Zeilinger
  • Patent number: 9359622
    Abstract: A method for production of a dihydrochalcone, especially of phloretin, using a transgenic microorganism, containing a nucleic acid section (a), comprising or consisting of a gene coding for a bacterial chalcone isomerase, and/or a nucleic acid section (a?), comprising or consisting of a gene coding for a plant chalcone isomerase, and a nucleic acid section (b), comprising or consisting of a gene coding for a bacterial enoate reductase, corresponding transgenic microorganisms, containing a nucleic acid section (a), comprising or consisting of a gene coding for a bacterial chalcone isomerase, and/or a nucleic acid section (a?), comprising or consisting of a gene coding for a plant chalcone isomerase, and/or a nucleic acid section (b), comprising or consisting of a gene coding for a bacterial enoate reductase, and host cells, containing one or more identical or different such vectors.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: June 7, 2016
    Assignee: SYMRISE AG
    Inventors: Jens Michael Hilmer, Egon Gross, Gerhard Krammer, Jakob Peter Ley, Mechthild Gall, Uwe Bornscheuer, Maren Thomsen, Christin Peters, Patrick Jonczyk, Sascha Beutel, Thomas Scheper
  • Publication number: 20160097724
    Abstract: The invention relates to a device and a method for automated evaluation of incubated immunoblot strips (5). What is essential for such immunoblot strips (5) is that these have regions coated with antigens, which regions discolour under the formation of so-called bands (6) as soon as a binding occurs, in particular between the antigen and an antibody present in a patient sample. Within the scope of the described technical solution, a camera (2) is initially used to make recordings of the surface of an incubated immunoblot strip (5) and these recordings are transmitted in digitized form to an evaluation unit (1). Finally, the discolourings, which occurred in the form of bands (6), are detected and at least partly quantified in the evaluation unit (1), such that a diagnosis suggestion is generated taking into account the number of bands (6) and the colour strength thereof.
    Type: Application
    Filed: April 4, 2014
    Publication date: April 7, 2016
    Applicant: EUROIMMUN MEDIZINISCHE LABORDIAGNOSTIKA AG
    Inventors: Wolfgang MEYER, Thomas SCHEPER, Robert KAFFKA
  • Publication number: 20150301035
    Abstract: An apparatus for detecting antibodies in a patient sample includes at least one incubation channel for accommodating a patient strip and for incubating the patient strip with a patient sample, a conjugate and a substrate and a control mechanism for visual inspection of incubation quality. A separate calibration strip has at least two control zones which are implemented in such a way that, owing to incubation with a reference sample, a conjugate and a substrate, a control band becomes visible in each case in the control zones in such a way that the color intensities of the control bands differ. An evaluation unit generates a calibration curve taking the different color intensities into account and ascertains, on the basis of the calibration curve, a quality value for an antibody-pathogen protein reaction which took place on the patient strip and information about antibody concentration in the patient sample examined.
    Type: Application
    Filed: September 19, 2012
    Publication date: October 22, 2015
    Inventors: Wolfgang Meyer, Thomas Scheper
  • Publication number: 20140228235
    Abstract: The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.
    Type: Application
    Filed: April 20, 2012
    Publication date: August 14, 2014
    Inventors: Dieter Melzner, Thomas Scheper, Thomas Schuler, Frank Stahl, Denise Van Rossum, Johanna-Gabriela Walter, Carsten Zeilinger
  • Publication number: 20140186971
    Abstract: A device for incubating an immunoblot strip (6) includes at least one incubation channel (1) into which an elongate immunoblot strip (6) having at least one biological material on its front is inserted with its back facing a channel base (2). An agitating means (7), with which the immunoblot strip (6) is agitatable around a transverse axis (8) of the strip (6) at least at times during incubation via an agitating device (7). For handling and/or grouping incubation channels (1) with immunoblot strips (6) inserted, a rack (3) for taking up at least two incubation channels (1) is provided. The rack (3) is in operative connection with said agitating means (7) via load transmission points.
    Type: Application
    Filed: May 3, 2013
    Publication date: July 3, 2014
    Applicant: Euroimmun Medizinische Labordiagnostika AG
    Inventors: Stöcker Winfried, Wolfgang Meyer, Thomas Scheper, Antje Euken
  • Publication number: 20140045233
    Abstract: A method for production of a dihydrochalcone, especially of phloretin, using a transgenic microorganism, containing a nucleic acid section (a), comprising or consisting of a gene coding for a bacterial chalcone isomerase, and/or a nucleic acid section (a?), comprising or consisting of a gene coding for a plant chalcone isomerase, and a nucleic acid section (b), comprising or consisting of a gene coding for a bacterial enoate reductase, corresponding transgenic microorganisms, containing a nucleic acid section (a), comprising or consisting of a gene coding for a bacterial chalcone isomerase, and/or a nucleic acid section (a?), comprising or consisting of a gene coding for a plant chalcone isomerase, and/or a nucleic acid section (b), comprising or consisting of a gene coding for a bacterial enoate reductase, and host cells, containing one or more identical or different such vectors.
    Type: Application
    Filed: July 30, 2013
    Publication date: February 13, 2014
    Inventors: Jens Michael Hilmer, Egon Gross, Gerhard Krammer, Jakob Peter Ley, Mechthild Gall, Uwe Bornscheuer, Maren Thomsen, Christin Peters, Patrick Jonczyk, Sascha Beutel, Thomas Scheper
  • Patent number: 8580199
    Abstract: A sensor for measuring an oxygen content in a liquid or gaseous sample has first and second sensor sections (14a, 14b). The first sensor section (14a) can be brought into contact with the sample and has a luminescent indicator dye embedded in an oxygen-permeable first polymer matrix. The second sensor section (14b) is arranged adjacent to the first sensor section (14a) and includes the same dye embedded in an oxygen-impermeable second polymer matrix. A light guide (10) guides luminescence excitation light from a light source (31, 32) to the sensor sections (14a, 14b) and guides luminescence emission light from the sensor section (14a, 14b) to a detector (39).
    Type: Grant
    Filed: January 10, 2007
    Date of Patent: November 12, 2013
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Michael Fritzsche
  • Patent number: 8252582
    Abstract: The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: August 28, 2012
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Daniel Riechers, Russell Hayden, Philip Nuzzo
  • Patent number: 7897051
    Abstract: The invention relates to a method for separating proteins from liquid media, comprising providing a liquid medium containing proteins, providing a clay material which has: a specific surface greater than 150 m2/g, a pore volume greater than 0.35 ml/g, an ion exchange capacity greater than 40 meq/100 g, and a sediment volume in water of less than 15 ml/2 g, equilibrating said clay material to a pH of from 3.5 to 9.0, treating said liquid medium with the equilibrated clay material, and separating the purified, protein-depleted liquid medium from the clay material.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: March 1, 2011
    Assignee: Sud-Chemie AG
    Inventors: Ulrich Sohling, Thomas Scheper, Cornelia Kasper, Daniel Riechers, Arne Burzlaff
  • Publication number: 20100035337
    Abstract: Bioreactor having at least one transparent window (5, 12, 13), the inner side (6) of which can be touched by a medium that can be arranged in a reactor interior (3), wherein the window (5, 12, 13) has a photocatalytic coating (7) on its inner side (6) facing the reactor interior (3), which coating can be activated by at least one light source from the outer side remote from the inner side (6).
    Type: Application
    Filed: July 16, 2009
    Publication date: February 11, 2010
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Detlef Bahnemann, Reinhard Baumfalk, Daniel Riechers, Thomas Scheper
  • Publication number: 20090306346
    Abstract: The invention relates to a method for separating proteins from liquid media, comprising providing a liquid medium containing proteins, providing a clay material which has: a specific surface greater than 150 m2/g, a pore volume greater than 0.35 ml/g, an ion exchange capacity greater than 40 meq/100 g, and a sediment volume in water of less than 15 ml/2 g, equilibrating said clay material to a pH of from 3.5 to 9.0, treating said liquid medium with the equilibrated clay material, and separating the purified, protein-depleted liquid medium from the clay material.
    Type: Application
    Filed: December 15, 2006
    Publication date: December 10, 2009
    Applicant: SUD-CHEMIE AG
    Inventors: Ulrich Sohling, Thomas Scheper, Kaspar Cornelia, Daniel Riechers, Arne Burzlaff
  • Publication number: 20090221809
    Abstract: The invention relates to a method for the sorption of at least one nucleic acid molecule from a liquid medium, comprising the following steps: (a) providing a liquid medium comprising at least one nucleic acid molecule; (b) providing a layer comprising at least one acid-activated phyllosilicate, where the layer is permeable by the liquid medium, and the layer thickness is at least 1 mm; (c) passing the liquid medium with the at least one nucleic acid molecule from step (a) through the layer from step (b) for sorption of the at least one nucleic acid molecule in the layer.
    Type: Application
    Filed: December 9, 2005
    Publication date: September 3, 2009
    Applicant: SUD-CHEMIE AG
    Inventors: Ulrich Sohling, Thomas Scheper, Kasper Cornelia, Kirstin Suck, Daniel Riechers
  • Publication number: 20090075362
    Abstract: The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.
    Type: Application
    Filed: April 24, 2007
    Publication date: March 19, 2009
    Applicants: Sartorius Stedim Biotech GmbH, Respironics Novametrix, LLC
    Inventors: Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Daniel Riechers, Russell Hayden, Philip Nuzzo
  • Publication number: 20070160500
    Abstract: The invention relates to a sensor for measuring an oxygen content in a liquid or gaseous sample, comprising a first sensor section (14a) that can be brought into contact with the sample and has a luminescent indicator dye embedded in an oxygen-permeable, first polymer matrix, light guiding means (10) for guiding luminescence excitation light from a light source (31, 32) to the first sensor section (14a), and light guiding means (10) for guiding luminescence emission light from the first sensor section (14a) to a detector (39). The invention is distinguished in that arranged adjacent to the first sensor section (14a) is a second sensor section (14b) that includes the same dye, embedded in an oxygen-impermeable, second polymer matrix.
    Type: Application
    Filed: January 10, 2007
    Publication date: July 12, 2007
    Applicant: Sartorius AG
    Inventors: Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Michael Fritzsche