Patents by Inventor Thomas Scheper
Thomas Scheper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240294607Abstract: The present invention relates to isolated, recombinant polypeptides comprising the gamma chain of fibrinogen and a His-Tag. The present invention further relates to nucleic acids encoding said polypeptides, vectors comprising said nucleic acids, host cells, preferably bacterial host cells, comprising said nucleic acids or vectors, biohybrid materials comprising conjugates comprising said polypeptides, uses of the above, and methods for producing said polypeptides.Type: ApplicationFiled: May 20, 2021Publication date: September 5, 2024Inventors: Thomas SCHEPER, Iliyana PELANOVA, Pia GELLERMANN, Sabrina GRÜNERT
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Patent number: 10914737Abstract: The invention relates to a device and a method for automated evaluation of incubated immunoblot strips (5). What is essential for such immunoblot strips (5) is that these have regions coated with antigens, which regions discolour under the formation of so-called bands (6) as soon as a binding occurs, in particular between the antigen and an antibody present in a patient sample. Within the scope of the described technical solution, a camera (2) is initially used to make recordings of the surface of an incubated immunoblot strip (5) and these recordings are transmitted in digitized form to an evaluation unit (1). Finally, the discolourings, which occurred in the form of bands (6), are detected and at least partly quantified in the evaluation unit (1), such that a diagnosis suggestion is generated taking into account the number of bands (6) and the colour strength thereof.Type: GrantFiled: April 4, 2014Date of Patent: February 9, 2021Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Wolfgang Meyer, Thomas Scheper, Robert Kaffka
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Patent number: 10802024Abstract: A method for diagnosing a limbic encephalitis, PNS, encephaloymyelitis, leukoencephalopathy, retinitis or optic atrophy, includes detecting a bornavirus in a sample, preferably from the group comprising mammalian 2 bornavirus, even more preferably VSBV-1, and mammalian 1 bornavirus, even more preferably BoDV-1; to a carrier containing a means for the capture of an antibody against at least one polypeptide selected from the group of BoDV-1-N, BoDV-1-P, VSBV-N and VSBV-P. A kit contains the carrier and a means for the detection of a captured antibody and a control for the detection of the presence of a sample. The carrier or kit or of a primer can be used for the detection of a bornavirus or a probe can be used for the diagnosis of an encephalitis, for the prognostication of post-transplantation complications, for the monitoring of a therapy of an encephalitis or of post-transplantation complications or for the differentiation between an autoimmune encephalitis and an encephalitis caused by infection.Type: GrantFiled: December 20, 2018Date of Patent: October 13, 2020Assignee: EUROIMMUN Medizinische Labordiagnostika AGInventors: Erik Lattwein, Wolfgang Meyer, Wolfgang Schlumberger, Julia Janz, Anthonina Ott, Thomas Scheper, Jonas Schmidt-Chanasit, Dennis Tappe
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Patent number: 10620191Abstract: A device for incubating an immunoblot strip (6) includes at least one incubation channel (1) into which an elongate immunoblot strip (6) having at least one biological material on its front is inserted with its back facing a channel base (2). An agitating means (7), with which the immunoblot strip (6) is agitatable around a transverse axis (8) of the strip (6) at least at times during incubation via an agitating device (7). For handling and/or grouping incubation channels (1) with immunoblot strips (6) inserted, a rack (3) for taking up at least two incubation channels (1) is provided. The rack (3) is in operative connection with said agitating means (7) via load transmission points.Type: GrantFiled: May 3, 2013Date of Patent: April 14, 2020Assignee: Euroimmun Medizinische Labordiagnostika AGInventors: Winfried Stöcker, Wolfgang Meyer, Thomas Scheper, Antje Euken
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Publication number: 20190204318Abstract: A method for diagnosing a limbic encephalitis, PNS, encephaloymyelitis, leukoencephalopathy, retinitis or optic atrophy, includes detecting a bornavirus in a sample, preferably from the group comprising mammalian 2 bornavirus, even more preferably VSBV-1, and mammalian 1 bornavirus, even more preferably BoDV-1; to a carrier containing a means for the capture of an antibody against at least one polypeptide selected from the group of BoDV-1-N, BoDV-1-P, VSBV-N and VSBV-P. A kit contains the carrier and a means for the detection of a captured antibody and a control for the detection of the presence of a sample. The carrier or kit or of a primer can be used for the detection of a bornavirus or a probe can be used for the diagnosis of an encephalitis, for the prognostication of post-transplantation complications, for the monitoring of a therapy of an encephalitis or of post-transplantation complications or for the differentiation between an autoimmune encephalitis and an encephalitis caused by infection.Type: ApplicationFiled: December 20, 2018Publication date: July 4, 2019Applicant: EUROIMMUN Medizinische Labordiagnostika AGInventors: Erik LATTWEIN, Wolfgang Meyer, Wolfgang Schlumberger, Julia Janz, Anthonina Ott, Thomas Scheper, Jonas Schmidt-Chanasit, Dennis Tappe
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Patent number: 9891230Abstract: The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.Type: GrantFiled: April 20, 2012Date of Patent: February 13, 2018Assignee: SARTORIUS STEDIM BIOTECH GMBHInventors: Dieter Melzner, Thomas Scheper, Thomas Schueler, Frank Stahl, Denise Van Rossum, Johanna-Gabriela Walter, Carsten Zeilinger
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Patent number: 9359622Abstract: A method for production of a dihydrochalcone, especially of phloretin, using a transgenic microorganism, containing a nucleic acid section (a), comprising or consisting of a gene coding for a bacterial chalcone isomerase, and/or a nucleic acid section (a?), comprising or consisting of a gene coding for a plant chalcone isomerase, and a nucleic acid section (b), comprising or consisting of a gene coding for a bacterial enoate reductase, corresponding transgenic microorganisms, containing a nucleic acid section (a), comprising or consisting of a gene coding for a bacterial chalcone isomerase, and/or a nucleic acid section (a?), comprising or consisting of a gene coding for a plant chalcone isomerase, and/or a nucleic acid section (b), comprising or consisting of a gene coding for a bacterial enoate reductase, and host cells, containing one or more identical or different such vectors.Type: GrantFiled: July 30, 2013Date of Patent: June 7, 2016Assignee: SYMRISE AGInventors: Jens Michael Hilmer, Egon Gross, Gerhard Krammer, Jakob Peter Ley, Mechthild Gall, Uwe Bornscheuer, Maren Thomsen, Christin Peters, Patrick Jonczyk, Sascha Beutel, Thomas Scheper
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Publication number: 20160097724Abstract: The invention relates to a device and a method for automated evaluation of incubated immunoblot strips (5). What is essential for such immunoblot strips (5) is that these have regions coated with antigens, which regions discolour under the formation of so-called bands (6) as soon as a binding occurs, in particular between the antigen and an antibody present in a patient sample. Within the scope of the described technical solution, a camera (2) is initially used to make recordings of the surface of an incubated immunoblot strip (5) and these recordings are transmitted in digitized form to an evaluation unit (1). Finally, the discolourings, which occurred in the form of bands (6), are detected and at least partly quantified in the evaluation unit (1), such that a diagnosis suggestion is generated taking into account the number of bands (6) and the colour strength thereof.Type: ApplicationFiled: April 4, 2014Publication date: April 7, 2016Applicant: EUROIMMUN MEDIZINISCHE LABORDIAGNOSTIKA AGInventors: Wolfgang MEYER, Thomas SCHEPER, Robert KAFFKA
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Publication number: 20150301035Abstract: An apparatus for detecting antibodies in a patient sample includes at least one incubation channel for accommodating a patient strip and for incubating the patient strip with a patient sample, a conjugate and a substrate and a control mechanism for visual inspection of incubation quality. A separate calibration strip has at least two control zones which are implemented in such a way that, owing to incubation with a reference sample, a conjugate and a substrate, a control band becomes visible in each case in the control zones in such a way that the color intensities of the control bands differ. An evaluation unit generates a calibration curve taking the different color intensities into account and ascertains, on the basis of the calibration curve, a quality value for an antibody-pathogen protein reaction which took place on the patient strip and information about antibody concentration in the patient sample examined.Type: ApplicationFiled: September 19, 2012Publication date: October 22, 2015Inventors: Wolfgang Meyer, Thomas Scheper
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Publication number: 20140228235Abstract: The present invention relates to a microarray device for the screening or the finding of protein inhibitors, to a method for the production thereof, and to a corresponding method for screening or finding protein inhibitors. The microarray device according to the invention comprises a solid supporting element having a support material, at least one protein immobilized thereon for which inhibitors are to be screened or found, and at least one known inhibitor of the at least one protein, the inhibitor being bound to the at least one protein and comprising a detectable label.Type: ApplicationFiled: April 20, 2012Publication date: August 14, 2014Inventors: Dieter Melzner, Thomas Scheper, Thomas Schuler, Frank Stahl, Denise Van Rossum, Johanna-Gabriela Walter, Carsten Zeilinger
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Publication number: 20140186971Abstract: A device for incubating an immunoblot strip (6) includes at least one incubation channel (1) into which an elongate immunoblot strip (6) having at least one biological material on its front is inserted with its back facing a channel base (2). An agitating means (7), with which the immunoblot strip (6) is agitatable around a transverse axis (8) of the strip (6) at least at times during incubation via an agitating device (7). For handling and/or grouping incubation channels (1) with immunoblot strips (6) inserted, a rack (3) for taking up at least two incubation channels (1) is provided. The rack (3) is in operative connection with said agitating means (7) via load transmission points.Type: ApplicationFiled: May 3, 2013Publication date: July 3, 2014Applicant: Euroimmun Medizinische Labordiagnostika AGInventors: Stöcker Winfried, Wolfgang Meyer, Thomas Scheper, Antje Euken
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Publication number: 20140045233Abstract: A method for production of a dihydrochalcone, especially of phloretin, using a transgenic microorganism, containing a nucleic acid section (a), comprising or consisting of a gene coding for a bacterial chalcone isomerase, and/or a nucleic acid section (a?), comprising or consisting of a gene coding for a plant chalcone isomerase, and a nucleic acid section (b), comprising or consisting of a gene coding for a bacterial enoate reductase, corresponding transgenic microorganisms, containing a nucleic acid section (a), comprising or consisting of a gene coding for a bacterial chalcone isomerase, and/or a nucleic acid section (a?), comprising or consisting of a gene coding for a plant chalcone isomerase, and/or a nucleic acid section (b), comprising or consisting of a gene coding for a bacterial enoate reductase, and host cells, containing one or more identical or different such vectors.Type: ApplicationFiled: July 30, 2013Publication date: February 13, 2014Inventors: Jens Michael Hilmer, Egon Gross, Gerhard Krammer, Jakob Peter Ley, Mechthild Gall, Uwe Bornscheuer, Maren Thomsen, Christin Peters, Patrick Jonczyk, Sascha Beutel, Thomas Scheper
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Patent number: 8580199Abstract: A sensor for measuring an oxygen content in a liquid or gaseous sample has first and second sensor sections (14a, 14b). The first sensor section (14a) can be brought into contact with the sample and has a luminescent indicator dye embedded in an oxygen-permeable first polymer matrix. The second sensor section (14b) is arranged adjacent to the first sensor section (14a) and includes the same dye embedded in an oxygen-impermeable second polymer matrix. A light guide (10) guides luminescence excitation light from a light source (31, 32) to the sensor sections (14a, 14b) and guides luminescence emission light from the sensor section (14a, 14b) to a detector (39).Type: GrantFiled: January 10, 2007Date of Patent: November 12, 2013Assignee: Sartorius Stedim Biotech GmbHInventors: Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Michael Fritzsche
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Patent number: 8252582Abstract: The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.Type: GrantFiled: April 24, 2007Date of Patent: August 28, 2012Assignee: Sartorius Stedim Biotech GmbHInventors: Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Daniel Riechers, Russell Hayden, Philip Nuzzo
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Patent number: 7897051Abstract: The invention relates to a method for separating proteins from liquid media, comprising providing a liquid medium containing proteins, providing a clay material which has: a specific surface greater than 150 m2/g, a pore volume greater than 0.35 ml/g, an ion exchange capacity greater than 40 meq/100 g, and a sediment volume in water of less than 15 ml/2 g, equilibrating said clay material to a pH of from 3.5 to 9.0, treating said liquid medium with the equilibrated clay material, and separating the purified, protein-depleted liquid medium from the clay material.Type: GrantFiled: December 15, 2006Date of Patent: March 1, 2011Assignee: Sud-Chemie AGInventors: Ulrich Sohling, Thomas Scheper, Cornelia Kasper, Daniel Riechers, Arne Burzlaff
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Publication number: 20100035337Abstract: Bioreactor having at least one transparent window (5, 12, 13), the inner side (6) of which can be touched by a medium that can be arranged in a reactor interior (3), wherein the window (5, 12, 13) has a photocatalytic coating (7) on its inner side (6) facing the reactor interior (3), which coating can be activated by at least one light source from the outer side remote from the inner side (6).Type: ApplicationFiled: July 16, 2009Publication date: February 11, 2010Applicant: Sartorius Stedim Biotech GmbHInventors: Detlef Bahnemann, Reinhard Baumfalk, Daniel Riechers, Thomas Scheper
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Publication number: 20090306346Abstract: The invention relates to a method for separating proteins from liquid media, comprising providing a liquid medium containing proteins, providing a clay material which has: a specific surface greater than 150 m2/g, a pore volume greater than 0.35 ml/g, an ion exchange capacity greater than 40 meq/100 g, and a sediment volume in water of less than 15 ml/2 g, equilibrating said clay material to a pH of from 3.5 to 9.0, treating said liquid medium with the equilibrated clay material, and separating the purified, protein-depleted liquid medium from the clay material.Type: ApplicationFiled: December 15, 2006Publication date: December 10, 2009Applicant: SUD-CHEMIE AGInventors: Ulrich Sohling, Thomas Scheper, Kaspar Cornelia, Daniel Riechers, Arne Burzlaff
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Publication number: 20090221809Abstract: The invention relates to a method for the sorption of at least one nucleic acid molecule from a liquid medium, comprising the following steps: (a) providing a liquid medium comprising at least one nucleic acid molecule; (b) providing a layer comprising at least one acid-activated phyllosilicate, where the layer is permeable by the liquid medium, and the layer thickness is at least 1 mm; (c) passing the liquid medium with the at least one nucleic acid molecule from step (a) through the layer from step (b) for sorption of the at least one nucleic acid molecule in the layer.Type: ApplicationFiled: December 9, 2005Publication date: September 3, 2009Applicant: SUD-CHEMIE AGInventors: Ulrich Sohling, Thomas Scheper, Kasper Cornelia, Kirstin Suck, Daniel Riechers
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Publication number: 20090075362Abstract: The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.Type: ApplicationFiled: April 24, 2007Publication date: March 19, 2009Applicants: Sartorius Stedim Biotech GmbH, Respironics Novametrix, LLCInventors: Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Daniel Riechers, Russell Hayden, Philip Nuzzo
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Publication number: 20070160500Abstract: The invention relates to a sensor for measuring an oxygen content in a liquid or gaseous sample, comprising a first sensor section (14a) that can be brought into contact with the sample and has a luminescent indicator dye embedded in an oxygen-permeable, first polymer matrix, light guiding means (10) for guiding luminescence excitation light from a light source (31, 32) to the first sensor section (14a), and light guiding means (10) for guiding luminescence emission light from the first sensor section (14a) to a detector (39). The invention is distinguished in that arranged adjacent to the first sensor section (14a) is a second sensor section (14b) that includes the same dye, embedded in an oxygen-impermeable, second polymer matrix.Type: ApplicationFiled: January 10, 2007Publication date: July 12, 2007Applicant: Sartorius AGInventors: Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Michael Fritzsche