Abstract: The present disclosure provides methods of treatment using ophthalmic compositions comprising semifluorinated alkanes for keratoconjunctivitis sicca and/or Meibomian gland dysfunction, which methods provide for the enrichment of an ophthalmic tissue in the semifluorinated alkane, and optionally methods of delayed release of the semifluorinated alkane from the enriched ophthalmic tissue to the surface of the cornea and/or conjunctiva, and/or to the Meibomian gland.

Abstract: The invention provides ophthalmic compositions comprising about 0.1 % (w/v) cyclosporine dissolved in 1-(perfluorobutyl)pentane for use in the topical treatment of dry eye disease. The invention further provides kits comprising such compositions for the same use.

Abstract: The invention provides ophthalmic compositions comprising about 0.1% (w/v) cyclosporine dissolved in 1-(perfluorobutyl)pentane for use in the topical treatment of dry eye disease and provides for treatment methods thereof. The invention further provides kits comprising such compositions.

Abstract: The present disclosure provides methods of treatment using ophthalmic compositions, comprising 1-perfluorohexyloctane, which are useful in the treatment of ocular surface damage of the cornea and/or symptoms of dryness.

Abstract: The invention provides ophthalmic compositions comprising about 0.1% (w/v) cyclosporine dissolved in 1-(perfluorobutyl)pentane for use in the topical treatment of dry eye disease. The invention further provides kits comprising such compositions for the same use.

Abstract: A facility for the recycling of biomaterial with a fermentation stage, whereby the fermentation stage has a fermentation chamber for the production of biogas through anaerobic fermentation of the biomaterial, and with a hygiene stage that is positioned downstream from the fermentation stage, whereby the hygiene stage has a hygienization chamber for the reception and the thermal hygienization of biomaterial discharged from the fermentation stage. A process for the recycling of biomaterial by zymosis is also provided, whereby biogas is produced in a fermentation stage through anaerobic fermentation of the biomaterial, whereby the biomaterial is, after flowing through the fermentation stage, conveyed to a hygiene stage in which the biomaterial thermal is hygienized, and whereby the biomaterial is, after flowing through the hygiene stage, made available as recyclable agricultural, hygienized fermentation residue.

Abstract: The present disclosure provides methods of treatment using ophthalmic compositions comprising semifluorinated alkanes for keratoconjunctivitis sicca and/or Meibomian gland dysfunction, which methods provide for the enrichment of an ophthalmic tissue in the semifluorinated alkane, and optionally methods of delayed release of the semifluorinated alkane from the enriched ophthalmic tissue to the surface of the cornea and/or conjunctiva, and/or to the Meibomian gland.

Abstract: Disclosed is a bioreactor, especially a plug flow bioreactor, including an agitator running along a longitudinal axis for thoroughly mixing a dry solid biomass that is to be outgassed in a fermentation chamber. In said bioreactor, an agitator shaft is mounted exclusively in two opposite end walls of the fermentation chamber while at least one free end of the agitator is connected to a drive unit outside the fermentation chamber.

Abstract: A facility for the recycling of biomaterial with a fermentation stage, whereby the fermentation stage has a fermentation chamber for the production of biogas through anaerobic fermentation of the biomaterial, and with a hygiene stage that is positioned downstream from the fermentation stage, whereby the hygiene stage has a hygienization chamber for the reception and the thermal hygienization of biomaterial discharged from the fermentation stage. A process for the recycling of biomaterial by zymosis is also provided, whereby biogas is produced in a fermentation stage through anaerobic fermentation of the biomaterial, whereby the biomaterial is, after flowing through the fermentation stage, conveyed to a hygiene stage in which the biomaterial thermal is hygienized, and whereby the biomaterial is, after flowing through the hygiene stage, made available as recyclable agricultural, hygienized fermentation residue.

Abstract: The invention provides modulators for the orphan nuclear receptor ROR? and methods for treating ROR? mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need thereof. Specifically, the present invention provides compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.

Abstract: The invention provides modulators for the orphan nuclear receptor ROR? and methods for treating ROR? mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need thereof. Specifically, the present invention provides compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.

Abstract: The invention relates to modulators for the orphan nuclear receptor RORgamma and methods for identification and screening of novel modulators for RORgamma activity as well as methods for treating RORgamma mediated diseases with novel RORgamma modulators identified by such methods.

Abstract: Disclosed is a bioreactor, especially a plug flow bioreactor, including an agitator running along a longitudinal axis for thoroughly mixing a dry solid biomass that is to be outgassed in a fermentation chamber. In said bioreactor, an agitator shaft is mounted exclusively in two opposite end walls of the fermentation chamber while at least one free end of the agitator is connected to a drive unit outside the fermentation chamber.