Abstract: A user interface unit for an automatic door drive comprises a display unit for outputting output information and a control element arrangement for capturing input information. The user interface unit, together with the door drive, is mountable in a first spatial position and in a second spatial position on a door that is drivable by the door drive. The control element arrangement comprises a first control element and a second control element, wherein the first control element is arranged in the first spatial position of the user interface unit on the same spatial side of the control element arrangement as the second control element in the second spatial position. The display unit is designed to display the displayed output information in the same spatial orientation in both the first spatial position and the second spatial position of the user interface unit.

Abstract: Described are methods for inhibition of Hepatitis B virus gene expression or treating symptoms and/or diseases associated with Hepatitis B virus infection. Dosing regimens for administering these RNAi agents are also described. RNA interference (RNAi) agents for inhibiting the expression of Hepatitis B virus gene are described. The HBV RNAi agents disclosed herein may be targeted to cells, such as hepatocytes, for example, by using conjugated targeting ligands. Pharmaceutical compositions comprising one or more HBV RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described HBV RNAi agents to infected liver in vivo provides for inhibition of HBV gene expression and treatment of diseases and conditions associated with HBV infection.

Abstract: Described herein is a cyclodextrin containing polymer conjugate.

Abstract: A user interface unit for an automatic door drive comprises a display unit for outputting output information and a control element arrangement for capturing input information. The user interface unit, together with the door drive, is mountable in a first spatial position and in a second spatial position on a door that is drivable by the door drive. The control element arrangement comprises a first control element and a second control element, wherein the first control element is arranged in the first spatial position of the user interface unit on the same spatial side of the control element arrangement as the second control element in the second spatial position. The display unit is designed to display the displayed output information in the same spatial orientation in both the first spatial position and the second spatial position of the user interface unit.

Abstract: Described herein is a cyclodextrin containing polymer conjugate.

Abstract: Described herein is a cyclodextrin containing polymer conjugate.

Abstract: Described herein is a cyclodextrin containing polymer conjugate.

Abstract: The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.

Abstract: Provided are methods relating to compositions that include a CDP-topoisomerase inhibitor, e.g., a CDP-camptothecin or camptothecin derivative conjugate, e.g., CRLX101.

Abstract: The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.

Abstract: Described herein is a cyclodextrin containing polymer conjugate.

Abstract: Provided are methods relating to compositions that include a CDP-topoisomerase inhibitor, e.g., a CDP-camptothecin or camptothecin derivative conjugate, e.g., CRLX101.

Abstract: Embodiments of an irreversible locking mechanism are presented herein. According to one embodiment, an irreversible locking mechanism comprises a body, a gate, and a spring-loaded pin. The body comprises two opposing ends separated by a gap. The gate is supported by a first of the two opposing ends and advances from the first opposing end to span the gap and engage a second of the two opposing ends such that the gate is engaged with the first and second opposing ends of the body. The gate transitions from an advancing state, where the spring-loaded pin is depressed within a seat in the first opposing end by the gate and the gate is free to span the gap, to an irreversible locked state, where the gate engages the second opposing end and the spring-loaded pin projects from the seat in the first opposing end into a catch of the gate.

Abstract: The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.

Abstract: In a method and system for controlling a revolving door that has a plurality of chambers defined by wings of a revolver, at least one imaging sensor is provided for acquiring images of a first area where the plurality of chambers rotatably pass by or through. A drive causes the revolver to rotate in a first direction from a first position where a user can enter a first chamber via the first opening. Images are acquired by the one imaging sensor and signals are acquired from a position sensor that is operative for outputting signals indicative of the angular position of the revolver. Based on the signals acquired from the position sensor, each imaging sensor or its output is disabled and/or each image acquired by each imaging sensor is ignored when each door wing is in field-of-view of the imaging sensor.

Abstract: A swinging automatic door control system includes an activation sensor for acquiring images of a first area where the door swings when opening or closing, a presence sensor for detecting motion in a second area that fronts a non-swinging side of the door when said door is closed, and a controller for controlling the opening and closing of the door as a function of the acquired images of a first area and the detection of motion in the second area.

Abstract: A radiation transmitting or sensing element is placed in a generally elongated holder of resilient material so that, if it is distorted by an accidental impact or otherwise, it will automatically re-orient itself when the intruding force is released. The invention is especially useful in safety accessories for automatic overhead doors, garages, and the like.

Abstract: The present invention provides a copolymer that noncovalently encapsulates an adenovirus while improving its delivery and resulting expression from the viral genome. It has now been discovered that a copolymer of a cationic polymer, such as PEI, polylysine, DEAE-Dextran, and derivatives thereof, and a nonionic polymer, such as PEG and derivatives thereof, can improve both delivery and transgene expression of the adenovirus in cells. The complex of the invention provides an easy-to-produce material that is therapeutically more effective than an unencapsulated adenovirus.