Patents by Inventor Thomas Schrader

Thomas Schrader has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10247068
    Abstract: An oil separating module for an internal combustion engine, including: an oil separator, an oil return arranged such that separated oil can flow through the oil return to an oil sump, a mounting, and a non-return valve having: a valve housing having a throughbore with a first end opening and a second end opening, and a valve body movably mounted in the valve housing such that the valve body transitions between an open position and a closed position. When the first end opening is above the second end opening, the valve body automatically transitions to, or remains in, the closed position when a second end opening pressure is greater than a first end opening pressure by at least a threshold pressure difference, and the valve body automatically transitions to, or remains in, the open position when the second pressure is not greater than the first pressure by at least the threshold pressure difference.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: April 2, 2019
    Assignee: BRUSS SEALING SYSTEMS GMBH
    Inventors: Manfred Brand, Doerte Petigk, Thomas Schrader
  • Publication number: 20170306816
    Abstract: A venting module for an internal combustion engine comprises an oil separator with an oil return line, and a check valve which is arranged in the oil return line. The check valve comprises a valve housing, a valve body which is held in the valve housing such that it can be displaced as an entirety between an open position and a closed position, wherein the valve body is held in the open position without prestress and as a result of gravity in the rest state of the internal combustion engine. During operation of the internal combustion engine, the valve body is in the open position independently of the prevailing gas pressure if a defined liquid level in the valve housing is not exceeded, and the valve body is set up for automatic displacement into the closed position as a result of buoyancy if a defined liquid level in the valve housing is exceeded.
    Type: Application
    Filed: October 2, 2015
    Publication date: October 26, 2017
    Applicant: BRUSS SEALING SYSTEMS GMBH
    Inventors: MANFRED BRAND, HARALD LEISNER, STEFAN RUST, ROLAND KRAL, THOMAS SCHRADER
  • Publication number: 20160363015
    Abstract: An oil separating module for an internal combustion engine, comprises an oil separator, an oil return which is arranged such that separated oil can flow through the oil return to an oil sump, a mounting and a non-return valve. The non-return valve comprises a valve housing, wherein the valve housing has a throughbore having a first end opening and a second end opening and a valve body, wherein the valve body is movably mounted in the valve housing such that the valve body transitions between an open position and a closed position. In the open position, fluids are able to pass from the first end opening to the second end opening and fluids are able to pass from the second end opening to the first end opening. In the closed position, fluids are not able to pass from the first end opening to the second end opening and fluids are not able to pass from the second end opening to the first end opening.
    Type: Application
    Filed: June 23, 2016
    Publication date: December 15, 2016
    Inventors: Manfred BRAND, Doerte PETIGK, Thomas SCHRADER
  • Patent number: 9416695
    Abstract: A non-return valve for an oil return in the crankcase ventilation system of a combustion engine includes a valve housing, a valve body which is mounted in the valve housing so as to be displaceable as a whole between an open position and a closed position, wherein the valve body in the non-operating state of the combustion engine is maintained in the open position without preload and the valve body is configured to automatically move to the closed position in case of an overpressure at the crankcase side with respect to the oil separator chamber. The non-return valve is provided and configured to be inserted into a mounting of a cylinder head cover of the combustion engine.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: August 16, 2016
    Assignee: BRUSS SEALING SYSTEMS GMBH
    Inventors: Manfred Brand, Doerte Petigk, Thomas Schrader
  • Patent number: 9107966
    Abstract: The invention is a method for reducing the viral and microbial content of biological extracts which contain solids. The method comprises the steps of, (1), providing a biological extract which contains solids that comprise a biologically active substance, selected from enzymes, proteins and peptides, or a mixture of such substances; and (2) subjecting the biological extract to a high-pressure treatment; wherein the biological activity of the biological extract after the high-pressure treatment is at least 50% of the biological activity of the biological extract before the high-pressure treatment.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: August 18, 2015
    Assignee: Nordmark Arzeimittel GmbH and Co, KG
    Inventors: Christian Rämsch, Thomas Schräder, Thomas Moest, Manfred Kurfürst
  • Publication number: 20140373797
    Abstract: A non-return valve for an oil return in the crankcase ventilation system of a combustion engine includes a valve housing, a valve body which is mounted in the valve housing so as to be displaceable as a whole between an open position and a closed position, wherein the valve body in the non-operating state of the combustion engine is maintained in the open position without preload and the valve body is configured to automatically move to the closed position in case of an overpressure at the crankcase side with respect to the oil separator chamber. The non-return valve is provided and configured to be inserted into a mounting of a cylinder head cover of the combustion engine.
    Type: Application
    Filed: June 25, 2014
    Publication date: December 25, 2014
    Inventors: Manfred Brand, Doerte Petigk, Thomas Schrader
  • Patent number: 8791092
    Abstract: This invention provides novel compositions to inhibit the aggregation of amyloid proteins. In various embodiments the compositions comprise a molecular tweezers that binds lysine and/or arginine and thereby inhibits the aggregation of amyloidogenic proteins.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: July 29, 2014
    Assignees: The Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs, Massachusetts Institute of Technology, Universitat Duisburg-Essen
    Inventors: Gal Bitan, Akila Shanmugam, Aleksey Lomakin, Thomas Schrader, Frank Gerrit Klarner, Peter Talbiersky, Jolanta Polkowska, Frank Bastkowski, Sharmistha Sinha, Sally Frautschy
  • Patent number: 8637555
    Abstract: The present invention relates to certain tetrazole derivatives of Formula (I), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of ?-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: January 28, 2014
    Assignees: Arena Pharmaceuticals, Inc., Merck & Co., Inc.
    Inventors: Graeme Semple, Thomas Schrader, Philip J. Skinner, Steven L. Colletti, Tawfik Gharbaoui, Jason E. Imbriglio, Jae-Kyu Jung, Rui Liang, Subharekha Raghavan, Darby Schmidt, James R. Tata
  • Patent number: 8569451
    Abstract: The present application relates to an affinity material useful in antibody purification.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: October 29, 2013
    Assignee: Biotage AB
    Inventors: Anthony Rees, Börje Sellergren, Ecevit Yilmaz, Thomas Schrader
  • Patent number: 8481494
    Abstract: The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: July 9, 2013
    Inventors: Thomas Schrader, Katrin Hochdörffer, Julia März-Berberich, Luitgard Nagel-Steger, Gal Bitan, Sharmistha Sinha
  • Publication number: 20120270795
    Abstract: The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: January 26, 2010
    Publication date: October 25, 2012
    Inventors: Thomas Schrader, Katrin Hochdörffer, Julia März-Berberich, Luitgard Nagel-Steger, Gal Bitan, Sharmistha Sinha
  • Patent number: 8283147
    Abstract: The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided in step (a) to a heat treatment at a temperature of 84° C., preferably 80° C. and below; wherein, the biological activity of the pancreatin obtained in step (b) corresponds to at least 50% of the biological activity of the pancreatin provided in step (a); and the viral infectiousness of the pancreatin obtained in step (b) has been reduced by a factor of more than 1 log10 in comparison with the viral infectiousness of the pancreatin provided in step (a), as well as a pancreatin produced according to this method and its use for producing a medicine or a nutritional supplement.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: October 9, 2012
    Assignee: Nordmark Arzneimittel GmbH & Co. KG
    Inventors: Manfred Kurfürst, Christian Rämsch, Thomas Schräder, Thomas Moest
  • Publication number: 20120108548
    Abstract: This invention provides novel compositions to inhibit the aggregation of amyloid proteins. In various embodiments the compositions comprise a molecular tweezers that binds lysine and/or arginine and thereby inhibits the aggregation of amyloidogenic proteins.
    Type: Application
    Filed: March 5, 2010
    Publication date: May 3, 2012
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITÄT DUISBURG-ESSEN, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Gal Bitan, Akila Shanmugam, Aleksey Lomakin, Thomas Schrader, Frank Gerrit Klarner, Peter Talbiersky, Jolanta Polkowska, Frank Bastkowski, Sharmistha Sinha, Sally Frautschy
  • Publication number: 20120095165
    Abstract: The present application relates to an affinity material useful in antibody purification.
    Type: Application
    Filed: April 9, 2010
    Publication date: April 19, 2012
    Applicant: BIOTAGE AB
    Inventors: Anthony Rees, Börje Sellergren, Ecevit Yilmaz, Thomas Schrader
  • Publication number: 20110268844
    Abstract: The invention relates to a method for reducing the viral and microbial content of biological extracts which contain solids. It is provided that the method comprises the steps (a) provision of the biological extract which contains solids, comprising a biologically active substance, selected from enzymes, proteins and peptides, or a mixture of such substances; and (b) subjecting the biological extract provided in step (a) to a high-pressure treatment; wherein the biological activity of the biological extract which contains solids after the high-pressure treatment is at least 50% of the biological activity of the biological extract which contains solids before the high-pressure treatment.
    Type: Application
    Filed: August 27, 2009
    Publication date: November 3, 2011
    Inventors: Christian Rämsch, Thomas Schräder, Thomas Moest, Manfred Kurfürst
  • Patent number: 7833612
    Abstract: A substrate for inkjet printing, which includes a photoresist layer structure on a base substrate, and a method of manufacturing the same are provided. The substrate, which has high surface tension variation and slight thickness variation, may be manufactured at a low cost. The substrate includes a discontinuous organic layer structure made of a fluorinated hydrocarbon or a polysiloxane on the photoresist layer structure.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: November 16, 2010
    Assignee: Samsung Mobile Display Co., Ltd.
    Inventors: Albrecht Uhlig, Michael Redecker, Marcus Schaedig, Thomas Schrader, Werner Humbs
  • Patent number: 7737631
    Abstract: A flat panel display and a method of manufacturing the same, which allows the formation of an organic film by inkjet printing while avoiding overflow of ink into adjacent areas, thus increasing the uniformity of thickness of the organic film and decreasing manufacturing costs. The flat panel display includes a substrate, a first electrode layer formed on the substrate, ink with material for a light emission layer formed on an active area of the first electrode layer, a repellant area formed of organic material located around the active area, and a border area also formed of organic material located between the active area and the repellant area. A surface energy of the border area is higher than a surface energy of the repellant area.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: June 15, 2010
    Assignee: Samsung Mobile Display Co., Ltd.
    Inventors: Albrecht Uhlig, Kerstin Nolte, Thomas Schrader
  • Publication number: 20100119654
    Abstract: The invention relates to a method for reducing the virus and micro-organism content of biological extracts which contain solids. It is provided that the method comprises the steps (a) provision of a biological extract which contains solids in the form of a suspension, which consists of a liquid phase and solid particles dispersed therein, wherein the extract in step (a) comprises a mixture of enzymes, proteins and peptides, some of which is dissolved in the liquid phase and some of which can be bound to the solid particles or is present in pulverulent, solid form; and (b) irradiation of the biological extract provided in step (a); wherein the radiation used for the irradiation is selected from the group comprising ultra-violet radiation, x-ray radiation, ? radiation and ? radiation; and the enzymic activity of the biological extract which contains solids after irradiation is at least 50% of the enzymic activity of the biological extract which contains solids before irradiation.
    Type: Application
    Filed: August 7, 2008
    Publication date: May 13, 2010
    Inventors: Christian Rämsch, Thomas Schräder, Thomas Moest, Manfred Kurfürat
  • Publication number: 20090233344
    Abstract: The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided in step (a) to a heat treatment at a temperature of 84° C., preferably 80° C. and below; wherein, the biological activity of the pancreatin obtained in step (b) corresponds to at least 50% of the biological activity of the pancreatin provided in step (a); and the viral infectiousness of the pancreatin obtained in step (b) has been reduced by a factor of more than 1 log10 in comparison with the viral infectiousness of the pancreatin provided in step (a), as well as a pancreatin produced according to this method and its use for producing a medicine or a nutritional supplement.
    Type: Application
    Filed: March 13, 2009
    Publication date: September 17, 2009
    Applicant: Nordmark Arzneimittel GmbH & Co. KG
    Inventors: MANFRED KURFURST, Christian Ramsch, Thomas Schrader, Thomas Moest
  • Patent number: 7553207
    Abstract: An organic light-emitting diode (OLED) with an increased service life and a method of manufacturing the same are provided. The OLED is subjected to electromagnetic radiation with a spectrum that at least partially overlaps the absorption spectrum of an organic material layer of the OLED. As a result, the OLED has a longer service life, reduced decay in its initial brightness, and more saturated color than a conventional OLED.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: June 30, 2009
    Assignee: Samsung Mobile Display Co., Ltd.
    Inventors: Albrecht Uhlig, Kerstin Nolte, Thomas Schrader