Abstract: Provided herein, inter alia, are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Provided herein, inter alia, are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: An electrical contact element having a frame clamp comprises a frame with a stationary thread, a clamping shoe and a clamping screw engaging in the stationary thread and being supported on the clamping shoe. A plastic holder with a cavity having two insertion openings arranged on opposite walls of the cavity is provided for inserting two electrical conductors to be contacted with one another, in which the frame clamp is arranged. The frame clamp is captively fixed in the cavity of the plastic holder by means of a latching. The frame clamp is mounted in a floating manner in the cavity of the plastic holder in the direction of at least one axis, which is oriented orthogonally to an insertion direction of the electrical contacts into the insertion openings.

Abstract: Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: The invention relates to an electrical conductor for conducting electric current through a housing part, wherein the electrical conductor is enclosed on a first sealing section by a sealing body made of an elastic material, wherein the electrical conductor and the sealing body have an integrally-bonded connection. The electrical conductor has, at least in the first sealing section, an outer contour which is rounded in cross-section. The invention further relates to a method for producing an electrical conductor with a sealing body, which is connected by integral bonding and is made of an elastic material.

Abstract: Described herein, inter alia, are LPAR1 antagonists and uses thereof.

Abstract: Provided herein, inter alia, are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds, pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Described herein, inter alia, are LPAR1 antagonists and uses thereof.

Abstract: Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Provided, inter alia, are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Disclosed herein, inter alia, are a crystalline compound of mAChR M1 antagonist, its pharmaceutical composition and methods of treatment.

Abstract: Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: An electrical contact element having a frame clamp comprises a frame with a stationary thread, a clamping shoe and a clamping screw engaging in the stationary thread and being supported on the clamping shoe. A plastic holder with a cavity having two insertion openings arranged on opposite walls of the cavity is provided for inserting two electrical conductors to be contacted with one another, in which the frame clamp is arranged. The frame clamp is captively fixed in the cavity of the plastic holder by means of a latching. The frame clamp is mounted in a floating manner in the cavity of the plastic holder in the direction of at least one axis, which is oriented orthogonally to an insertion direction of the electrical contacts into the insertion openings.

Abstract: Provided herein, inter alia, are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: The invention relates to an electrical conductor for conducting electric current through a housing part, wherein the electrical conductor is enclosed on a first sealing section by a sealing body made of an elastic material, wherein the electrical conductor and the sealing body have an integrally-bonded connection. The electrical conductor has, at least in the first sealing section, an outer contour which is rounded in cross-section. The invention further relates to a method for producing an electrical conductor with a sealing body, which is connected by integral bonding and is made of an elastic material.

Abstract: Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Abstract: Provided herein are compounds which are useful as antagonists of the muscarinic acetylcholine receptor M1 (mAChR M1); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.