Patents by Inventor Thomas Schurpf

Thomas Schurpf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20200131259
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: January 7, 2020
    Publication date: April 30, 2020
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • Compositions and methods for growth factor modulation
    Patent number: 10597443
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: March 24, 2020
    Assignee: Scholar Rock, Inc.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • ISOFORM-SELECTIVE TGFB1 INHIBITORS AND USE THEREOF
    Publication number: 20200079840
    Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.
    Type: Application
    Filed: July 11, 2019
    Publication date: March 12, 2020
    Inventors: Abhishek Datta, Allan Capili, Thomas Schurpf, Constance Martin, Kevin B. Dagbay, Christopher Chapron, Stefan Wawersik, Christopher Littlefield, Gregory J. Carven, Alan Buckler, Susan Lin, Justin W. Jackson
  • TGFBeta Antibodies, Methods and Uses
    Publication number: 20190292254
    Abstract: ProTGFB1-GARP complex-selective antibodies, polynucleotides capable of encoding the proTGFB1-GARP complex-selective antibodies or antigen-binding fragments, cells expressing proTGFB1-GARP complex-selective antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled proTGFB1-GARP complex-selective antibodies or antigen-binding fragments may be used to enhance an immune response in a subject, for example, against a cancer.
    Type: Application
    Filed: July 14, 2017
    Publication date: September 26, 2019
    Inventors: Gregory J. Carven, Thomas Schurpf, Katherine Turner
  • ISOFORM-SPECIFIC, CONTEXT-PERMISSIVE TGFB1 INHIBITORS AND USE THEREOF
    Publication number: 20190209682
    Abstract: Disclosed herein are therapeutic use of isoform-specific, context-permissive inhibitors of TGF?1 in the treatment of disease that involve TGF?1 dysregulation.
    Type: Application
    Filed: March 22, 2019
    Publication date: July 11, 2019
    Inventors: Thomas Schurpf, Abhishek Datta, Gregory J. Carven, Constance Martin, Ashish Kalra, Kimberly Long, Alan Buckler
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20190085067
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: December 4, 2018
    Publication date: March 21, 2019
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
  • TGFbeta1-BINDING IMMUNOGLOBULINS AND USE THEREOF
    Publication number: 20190071493
    Abstract: Disclosed herein are immunoglobulins, such as antibodies, and antigen binding portions thereof, that specifically bind complexes of GARP-TGF?1, LTBP1-TGF?1, LTBP3-TGF?1, and/or LRRC33-TGF?1. The application also provides methods of use of these immunoglobulins for, for example, inhibiting TGF?1 activity, and treating subjects suffering from TGF?1-related disorders, such as cancer and fibrosis.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 7, 2019
    Inventors: Thomas Schurpf, Gregory J. Carven, Abhishek Datta, Kimberly Long
  • ISOFORM-SPECIFIC, CONTEXT-PERMISSIVE TGFB1 INHIBITORS AND USE THEREOF
    Publication number: 20180207267
    Abstract: Disclosed herein are therapeutic use of isoform-specific, context-permissive inhibitors of TGF?1 in the treatment of disease that involve TGF?1 dysregulation.
    Type: Application
    Filed: January 5, 2018
    Publication date: July 26, 2018
    Inventors: Thomas Schurpf, Abhishek Datta, Gregory J. Carven, Constance Martin, Ashish Kalra, Kimberly Long, Alan Buckler
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20180022798
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: August 8, 2017
    Publication date: January 25, 2018
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20180016332
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: July 26, 2017
    Publication date: January 18, 2018
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Straub
  • Compositions and methods for growth factor modulation
    Patent number: 9758576
    Abstract: Provided herein are antibodies that bind growth factor prodomain complexes, for example, growth factor prodomain complexes that include GDF-8 growth factor and GDF-8 prodomain. Also included are antibodies that bind growth factor prodomain complexes that have been altered by proteolytic processing.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: September 12, 2017
    Assignee: Scholar Rock, Inc.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • Compositions and methods for growth factor modulation
    Patent number: 9758577
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: September 12, 2017
    Assignee: Scholar Rock, Inc.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20170210798
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: January 9, 2017
    Publication date: July 27, 2017
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20170190767
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: January 12, 2017
    Publication date: July 6, 2017
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20170073406
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: May 6, 2015
    Publication date: March 16, 2017
    Inventors: Thomas Schurpf, Gregory P. Chang, Nagesh K. Mahanthappa
  • Compositions and methods for growth factor modulation
    Patent number: 9580500
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: February 28, 2017
    Assignee: SCHOLAR ROCK, INC.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • Compositions and methods for growth factor modulation
    Patent number: 9573995
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: February 21, 2017
    Assignee: SCHOLAR ROCK, INC.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20160289318
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: June 20, 2016
    Publication date: October 6, 2016
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • Compositions and methods for growth factor modulation
    Patent number: 9399676
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: July 26, 2016
    Assignee: SCHOLAR ROCK, INC.
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub
  • COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
    Publication number: 20160031980
    Abstract: Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-? superfamily of proteins.
    Type: Application
    Filed: July 9, 2015
    Publication date: February 4, 2016
    Inventors: Thomas Schurpf, Nagesh K. Mahanthappa, Michelle Marie Straub