Patents by Inventor Thomas Simpson
Thomas Simpson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8071621Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.Type: GrantFiled: October 9, 2009Date of Patent: December 6, 2011Assignee: AstraZeneca ABInventors: Thomas Simpson, James Kang, Jeffrey Albert, Cristobal Alhambra, Gerard Koether, James Woods, Yan Li
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Patent number: 8014714Abstract: Fusers, printing apparatuses and methods of fusing toner on media are disclosed. An embodiment of a fuser for heating media includes a fuser roll including an outer portion having a first outer surface; a voltage source connected to the outer portion and adapted to supply voltage to the outer portion to heat the first outer surface; a pressure roll having a second outer surface; and a nip between the first and second outer surfaces. The first and second outer surfaces are adapted to contact a medium at the nip.Type: GrantFiled: August 28, 2008Date of Patent: September 6, 2011Assignee: Xerox CorporationInventors: Steven Donald, Christopher L. Bradley, Fred Johnson, Thomas Simpson, Robert Arnold
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Publication number: 20110136804Abstract: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.Type: ApplicationFiled: November 5, 2010Publication date: June 9, 2011Applicant: AstraZeneca ABInventors: Hui-Fang Chang, Christopher Holmquist, Eifion Phillips, Timothy Piser, Thomas Simpson, Rebecca Urbanek, James Woods, Hui Xiong
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Patent number: 7842803Abstract: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.Type: GrantFiled: May 17, 2007Date of Patent: November 30, 2010Assignee: AstraZeneca ABInventors: Hui-Fang Chang, Christopher Holmquist, Eifion Phillips, Timothy Piser, Thomas Simpson, Rebecca Urbanek, James Woods, Hui Xiong
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Publication number: 20100054784Abstract: Fusers, printing apparatuses and methods of fusing toner on media are disclosed. An embodiment of a fuser for heating media includes a fuser roll including an outer portion having a first outer surface; a voltage source connected to the outer portion and adapted to supply voltage to the outer portion to heat the first outer surface; a pressure roll having a second outer surface; and a nip between the first and second outer surfaces. The first and second outer surfaces are adapted to contact a medium at the nip.Type: ApplicationFiled: August 28, 2008Publication date: March 4, 2010Applicant: XEROX CORPORATIONInventors: Steven DONALD, Christopher L. Bradley, Fred Johnson, Thomas Simpson, Robert Arnold
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Publication number: 20100029717Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.Type: ApplicationFiled: October 9, 2009Publication date: February 4, 2010Inventors: Thomas Simpson, James Kang, Jeffrey Albert, Cristobal Alhambra, Gerard Koether, James Woods, Yan Li
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Publication number: 20090054445Abstract: Compounds of Formula I wherein R1, A, R2, n, R3, m, R4, R5 and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.Type: ApplicationFiled: January 25, 2007Publication date: February 26, 2009Applicant: ASTRAZENECA ABInventors: Jeffrey Albert, Cristobal Alhambra, James Kang, Gerard Koether, Yan Li, Thomas Simpson, James Woods
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Publication number: 20080293765Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.Type: ApplicationFiled: December 11, 2006Publication date: November 27, 2008Inventors: Jeffrey Albert, Cristobal Alhambra, James Kang, Gerard Koether, Thomas Simpson, James Woods, Yan Li
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Publication number: 20080139600Abstract: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.Type: ApplicationFiled: May 17, 2007Publication date: June 12, 2008Applicant: AstraZeneca ABInventors: Hui-Fang Chang, Christopher Holmquist, Eifion Phillips, Timothy Piser, Thomas Simpson, Rebecca Urbanek, James Woods, Hui Xiong
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Publication number: 20080081833Abstract: Compounds of Formula I: wherein A1, A2, D and E are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.Type: ApplicationFiled: December 16, 2005Publication date: April 3, 2008Applicant: AstraZeneca ABInventors: Glen Ernst, William Frietze, Thomas Simpson
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Publication number: 20080076752Abstract: Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid ? protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit ? secretase and thereby inhibit the production of amyloid ? protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.Type: ApplicationFiled: August 24, 2007Publication date: March 27, 2008Applicant: ASTRAZENECA ABInventors: Christopher Becker, Bruce Dembofsky, Robert Jacobs, James Kang, Cyrus Ohnmacht, James Rosamond, Ashokkumar Shenvi, Thomas Simpson, James Woods
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Publication number: 20080051441Abstract: Compounds of Formula I: wherein R1, R2, R3, R4, R5 Ar1 and X are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.Type: ApplicationFiled: December 23, 2005Publication date: February 28, 2008Applicant: AstraZeneca ABInventors: Dean Brown, Frances McLaren, Thomas Simpson
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Publication number: 20080021062Abstract: Compounds of Formula II wherein R1, A, R2, R3, R4, R5, R8, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.Type: ApplicationFiled: December 11, 2006Publication date: January 24, 2008Inventors: Thomas Simpson, James Kang, Jeffrey Albert, Cristobal Alhambra, Gerard Koether, James Woods, Yan Li
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Patent number: 7294622Abstract: Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid ? protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit ? secretase and thereby inhibit the production of amyloid ? protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.Type: GrantFiled: October 2, 2003Date of Patent: November 13, 2007Assignee: Astrazeneca ABInventors: Christopher Becker, Bruce Dembofsky, Robert Jacobs, James Kang, Cyrus Ohnmacht, James Rosamond, Ashokkumar Bhikkappa Shenvi, Thomas Simpson, James Woods
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Publication number: 20070248912Abstract: This invention pertains to a method and apparatus for thermally developing a photosensitive element. The photosensitive element includes a composition layer capable of being partially liquefied upon heating. Heating the layer causes one or more organic compounds in the layer to form a vapor. Oxidation of the vapor forms carbon dioxide and water vapor and reduces the need to manage waste streams containing the organic compounds.Type: ApplicationFiled: April 24, 2006Publication date: October 25, 2007Inventors: Mark Hackler, James Grant, Bernard Hoff, Carmo Pereira, Wilford Shamlin, Thomas Simpson
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Publication number: 20070179172Abstract: Compounds of Formula I or Formula II wherein R1, X and Ar are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.Type: ApplicationFiled: May 4, 2004Publication date: August 2, 2007Inventors: Christopher Becker, Jeanne Comstock, William Michne, Megan Murphy, Eifion Phillips, James Rosamond, Thomas Simpson
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Publication number: 20070146702Abstract: An automated computer-controlled method and apparatus for measuring the quality or fineness of a pigment dispersion sample, comprising placing the pigment dispersion at the deep end of the tapered path of a Hegman gage block, placing the Hegman gage block in a holder in a motorized drawdown device that draws the scraper along the length of the tapered path at an angle and to at a contact pressure and at a controlled rate, thereby creating a tapered film sample of paint whose thickness tapers from a maximum thickness of 100 micrometers to a minimum thickness of zero. An illuminator assembly illuminates the sample with a substantially collimated light source at an intensity level and the light reflected from the sample is collected by a lens onto a photodetector array in a digital camera. After a time interval the camera acquires an image of the sample.Type: ApplicationFiled: December 9, 2005Publication date: June 28, 2007Inventors: Robert Canning, Scott Mehr, Barry Rubin, Thomas Simpson, Douglas Stilwell
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Publication number: 20070131018Abstract: A flow cell for measuring the color properties of a liquid flowing therethrough using interrogating radiation at a predetermined wavelength has a thin partition mounted in spaced relationship between both a window and a base of the cell. The partition and the window define an air cavity therebetween. The spacing between the partition and the window is such that evanescent coupling of radiation reflected from the liquid into the material of the window is prevented. The cell has a pressurized fluid inflow channel and a pressurized fluid outflow channel formed therein. Each of the inflow and outflow channels communicates with the air cavity. The inflow and outflow channels are sized to pass a pressurized fluid, such as pressurized air, through the air cavity such that, in use, the spaced relationship between the partition and the window is maintained by pressurized fluid in the air cavity.Type: ApplicationFiled: December 5, 2006Publication date: June 14, 2007Applicant: E. I. DUPONT DE NEMOURS AND COMPANYInventors: Jeff Alspach, Anthony Martino, Matthew Reinhardt, Ken Schermacher, Thomas Simpson
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Publication number: 20070132991Abstract: A system utilizing the flow cell of the present invention includes a reflectance mode spectrophotometer positioned with respect to the flow cell or a probe. Either the flow cell or the probe has a thin partition mounted in spaced relationship with respect to a transparent window. The partition has a predetermined index of refraction and has a thickness dimension that is less than that of the window. The spacing between the partition and the window is such that evanescent coupling of radiation reflected from the liquid into the material of the window is prevented. The spectrophotometer is directs interrogating radiation toward a liquid flowing through the sample chamber and responds to interrogating radiation reflected from the liquid to produce an electrical signal representative of a color property thereof.Type: ApplicationFiled: December 5, 2006Publication date: June 14, 2007Applicant: E. I. DUPONT DE NEMOURS AND CONPANYInventors: Jeff Alspach, Jason Juhasz, Anthony Martino, Matthew Reinhardt, Ken Schermacher, Thomas Simpson
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Publication number: 20070132992Abstract: A flow cell for measuring the color properties of a liquid flowing through the flow cell using interrogating radiation at a predetermined wavelength has a thin partition mounted in spaced relationship between both a window and a base of the cell. The partition has a predetermined index of refraction and has a thickness dimension that is less than that of the window. The spacing between the partition and the window is such that evanescent coupling of radiation reflected from the liquid into the material of the window is prevented. Typically, this spacing is a distance not less than three (3) times the predetermined maximum wavelength in the wavelength range of interrogating radiation. A plurality of spacer elements may be disposed in the air cavity to maintain the spaced relationship between the partition and the window. The flow cell has a liquid supply passage and a liquid removal passage formed therein.Type: ApplicationFiled: December 5, 2006Publication date: June 14, 2007Applicant: E. I. DUPONT DE NEMOURS AND COMPANYInventors: Jeff Alspach, Jason Juhasz, Anthony Martino, Matthew Reinhardt, Ken Schermacher, Thomas Simpson