Patents by Inventor Thomas Simpson

Thomas Simpson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8071621
    Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 6, 2011
    Assignee: AstraZeneca AB
    Inventors: Thomas Simpson, James Kang, Jeffrey Albert, Cristobal Alhambra, Gerard Koether, James Woods, Yan Li
  • Patent number: 8014714
    Abstract: Fusers, printing apparatuses and methods of fusing toner on media are disclosed. An embodiment of a fuser for heating media includes a fuser roll including an outer portion having a first outer surface; a voltage source connected to the outer portion and adapted to supply voltage to the outer portion to heat the first outer surface; a pressure roll having a second outer surface; and a nip between the first and second outer surfaces. The first and second outer surfaces are adapted to contact a medium at the nip.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: September 6, 2011
    Assignee: Xerox Corporation
    Inventors: Steven Donald, Christopher L. Bradley, Fred Johnson, Thomas Simpson, Robert Arnold
  • Publication number: 20110136804
    Abstract: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.
    Type: Application
    Filed: November 5, 2010
    Publication date: June 9, 2011
    Applicant: AstraZeneca AB
    Inventors: Hui-Fang Chang, Christopher Holmquist, Eifion Phillips, Timothy Piser, Thomas Simpson, Rebecca Urbanek, James Woods, Hui Xiong
  • Patent number: 7842803
    Abstract: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: November 30, 2010
    Assignee: AstraZeneca AB
    Inventors: Hui-Fang Chang, Christopher Holmquist, Eifion Phillips, Timothy Piser, Thomas Simpson, Rebecca Urbanek, James Woods, Hui Xiong
  • Publication number: 20100054784
    Abstract: Fusers, printing apparatuses and methods of fusing toner on media are disclosed. An embodiment of a fuser for heating media includes a fuser roll including an outer portion having a first outer surface; a voltage source connected to the outer portion and adapted to supply voltage to the outer portion to heat the first outer surface; a pressure roll having a second outer surface; and a nip between the first and second outer surfaces. The first and second outer surfaces are adapted to contact a medium at the nip.
    Type: Application
    Filed: August 28, 2008
    Publication date: March 4, 2010
    Applicant: XEROX CORPORATION
    Inventors: Steven DONALD, Christopher L. Bradley, Fred Johnson, Thomas Simpson, Robert Arnold
  • Publication number: 20100029717
    Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: October 9, 2009
    Publication date: February 4, 2010
    Inventors: Thomas Simpson, James Kang, Jeffrey Albert, Cristobal Alhambra, Gerard Koether, James Woods, Yan Li
  • Publication number: 20090054445
    Abstract: Compounds of Formula I wherein R1, A, R2, n, R3, m, R4, R5 and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: January 25, 2007
    Publication date: February 26, 2009
    Applicant: ASTRAZENECA AB
    Inventors: Jeffrey Albert, Cristobal Alhambra, James Kang, Gerard Koether, Yan Li, Thomas Simpson, James Woods
  • Publication number: 20080293765
    Abstract: Compounds of Formula I wherein R1, A, R2, R3, R4, R5, R8, n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: December 11, 2006
    Publication date: November 27, 2008
    Inventors: Jeffrey Albert, Cristobal Alhambra, James Kang, Gerard Koether, Thomas Simpson, James Woods, Yan Li
  • Publication number: 20080139600
    Abstract: Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R1 and R2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.
    Type: Application
    Filed: May 17, 2007
    Publication date: June 12, 2008
    Applicant: AstraZeneca AB
    Inventors: Hui-Fang Chang, Christopher Holmquist, Eifion Phillips, Timothy Piser, Thomas Simpson, Rebecca Urbanek, James Woods, Hui Xiong
  • Publication number: 20080081833
    Abstract: Compounds of Formula I: wherein A1, A2, D and E are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.
    Type: Application
    Filed: December 16, 2005
    Publication date: April 3, 2008
    Applicant: AstraZeneca AB
    Inventors: Glen Ernst, William Frietze, Thomas Simpson
  • Publication number: 20080076752
    Abstract: Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid ? protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit ? secretase and thereby inhibit the production of amyloid ? protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
    Type: Application
    Filed: August 24, 2007
    Publication date: March 27, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Christopher Becker, Bruce Dembofsky, Robert Jacobs, James Kang, Cyrus Ohnmacht, James Rosamond, Ashokkumar Shenvi, Thomas Simpson, James Woods
  • Publication number: 20080051441
    Abstract: Compounds of Formula I: wherein R1, R2, R3, R4, R5 Ar1 and X are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.
    Type: Application
    Filed: December 23, 2005
    Publication date: February 28, 2008
    Applicant: AstraZeneca AB
    Inventors: Dean Brown, Frances McLaren, Thomas Simpson
  • Publication number: 20080021062
    Abstract: Compounds of Formula II wherein R1, A, R2, R3, R4, R5, R8, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
    Type: Application
    Filed: December 11, 2006
    Publication date: January 24, 2008
    Inventors: Thomas Simpson, James Kang, Jeffrey Albert, Cristobal Alhambra, Gerard Koether, James Woods, Yan Li
  • Patent number: 7294622
    Abstract: Compounds having the formula (I) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid ? protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit ? secretase and thereby inhibit the production of amyloid ? protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: November 13, 2007
    Assignee: Astrazeneca AB
    Inventors: Christopher Becker, Bruce Dembofsky, Robert Jacobs, James Kang, Cyrus Ohnmacht, James Rosamond, Ashokkumar Bhikkappa Shenvi, Thomas Simpson, James Woods
  • Publication number: 20070248912
    Abstract: This invention pertains to a method and apparatus for thermally developing a photosensitive element. The photosensitive element includes a composition layer capable of being partially liquefied upon heating. Heating the layer causes one or more organic compounds in the layer to form a vapor. Oxidation of the vapor forms carbon dioxide and water vapor and reduces the need to manage waste streams containing the organic compounds.
    Type: Application
    Filed: April 24, 2006
    Publication date: October 25, 2007
    Inventors: Mark Hackler, James Grant, Bernard Hoff, Carmo Pereira, Wilford Shamlin, Thomas Simpson
  • Publication number: 20070179172
    Abstract: Compounds of Formula I or Formula II wherein R1, X and Ar are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.
    Type: Application
    Filed: May 4, 2004
    Publication date: August 2, 2007
    Inventors: Christopher Becker, Jeanne Comstock, William Michne, Megan Murphy, Eifion Phillips, James Rosamond, Thomas Simpson
  • Publication number: 20070146702
    Abstract: An automated computer-controlled method and apparatus for measuring the quality or fineness of a pigment dispersion sample, comprising placing the pigment dispersion at the deep end of the tapered path of a Hegman gage block, placing the Hegman gage block in a holder in a motorized drawdown device that draws the scraper along the length of the tapered path at an angle and to at a contact pressure and at a controlled rate, thereby creating a tapered film sample of paint whose thickness tapers from a maximum thickness of 100 micrometers to a minimum thickness of zero. An illuminator assembly illuminates the sample with a substantially collimated light source at an intensity level and the light reflected from the sample is collected by a lens onto a photodetector array in a digital camera. After a time interval the camera acquires an image of the sample.
    Type: Application
    Filed: December 9, 2005
    Publication date: June 28, 2007
    Inventors: Robert Canning, Scott Mehr, Barry Rubin, Thomas Simpson, Douglas Stilwell
  • Publication number: 20070131018
    Abstract: A flow cell for measuring the color properties of a liquid flowing therethrough using interrogating radiation at a predetermined wavelength has a thin partition mounted in spaced relationship between both a window and a base of the cell. The partition and the window define an air cavity therebetween. The spacing between the partition and the window is such that evanescent coupling of radiation reflected from the liquid into the material of the window is prevented. The cell has a pressurized fluid inflow channel and a pressurized fluid outflow channel formed therein. Each of the inflow and outflow channels communicates with the air cavity. The inflow and outflow channels are sized to pass a pressurized fluid, such as pressurized air, through the air cavity such that, in use, the spaced relationship between the partition and the window is maintained by pressurized fluid in the air cavity.
    Type: Application
    Filed: December 5, 2006
    Publication date: June 14, 2007
    Applicant: E. I. DUPONT DE NEMOURS AND COMPANY
    Inventors: Jeff Alspach, Anthony Martino, Matthew Reinhardt, Ken Schermacher, Thomas Simpson
  • Publication number: 20070132991
    Abstract: A system utilizing the flow cell of the present invention includes a reflectance mode spectrophotometer positioned with respect to the flow cell or a probe. Either the flow cell or the probe has a thin partition mounted in spaced relationship with respect to a transparent window. The partition has a predetermined index of refraction and has a thickness dimension that is less than that of the window. The spacing between the partition and the window is such that evanescent coupling of radiation reflected from the liquid into the material of the window is prevented. The spectrophotometer is directs interrogating radiation toward a liquid flowing through the sample chamber and responds to interrogating radiation reflected from the liquid to produce an electrical signal representative of a color property thereof.
    Type: Application
    Filed: December 5, 2006
    Publication date: June 14, 2007
    Applicant: E. I. DUPONT DE NEMOURS AND CONPANY
    Inventors: Jeff Alspach, Jason Juhasz, Anthony Martino, Matthew Reinhardt, Ken Schermacher, Thomas Simpson
  • Publication number: 20070132992
    Abstract: A flow cell for measuring the color properties of a liquid flowing through the flow cell using interrogating radiation at a predetermined wavelength has a thin partition mounted in spaced relationship between both a window and a base of the cell. The partition has a predetermined index of refraction and has a thickness dimension that is less than that of the window. The spacing between the partition and the window is such that evanescent coupling of radiation reflected from the liquid into the material of the window is prevented. Typically, this spacing is a distance not less than three (3) times the predetermined maximum wavelength in the wavelength range of interrogating radiation. A plurality of spacer elements may be disposed in the air cavity to maintain the spaced relationship between the partition and the window. The flow cell has a liquid supply passage and a liquid removal passage formed therein.
    Type: Application
    Filed: December 5, 2006
    Publication date: June 14, 2007
    Applicant: E. I. DUPONT DE NEMOURS AND COMPANY
    Inventors: Jeff Alspach, Jason Juhasz, Anthony Martino, Matthew Reinhardt, Ken Schermacher, Thomas Simpson