Patents by Inventor Thomas Solacroup

Thomas Solacroup has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell culture methods for increased cell viability
    Patent number: 11254964
    Abstract: The present invention relates to a method of maintaining cell viability at a level of at least 80% for up to 14 days in a fed-batch culture of cells producing a recombinant protein, the method comprising maintaining the cell culture medium at a pH of 6.5 to 7.0 and at a temperature of 31° C. to 35° C. for at least 5 consecutive days of the duration of the cell culture method.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: February 22, 2022
    Assignee: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Matthieu Stettler, Hervé Broly, Thomas Solacroup, Yolande Rouiller
  • Methods for increasing biosimilarity
    Patent number: 11186858
    Abstract: The present invention relates to a method of increasing biosimilarity of a TNF ? binding protein to a reference TNF ? binding protein by modifying the charge profile of the binding protein produced by cell culture in a cell culture medium, by making an adjustment to a cell culture condition The adjustment is an increase in the concentration of a metal ion in the cell culture medium and the adjustment occurs on one or more days during the cell culture method, whereby the adjustment in the cell culture condition results in the modification of the charge profile of the binding protein. The present invention also relates to a biosimilar protein obtainable by such a process.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: November 30, 2021
    Assignee: FRESENIUS KABI DEUTSCHLAND GMBH
    Inventors: Thomas Solacroup, Matthieu Stettler, Martin Jordan, Hervé Broly
  • Method of reducing serine for asparagine misincorporation
    Patent number: 10526631
    Abstract: The present invention relates to a method of reducing serine for asparagine misincorporation in a protein produced by a culture of cells in a cell culture method, the method comprising the addition of asparagine and iron to the cell culture medium.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: January 7, 2020
    Assignee: ARES TRADING S.A.
    Inventors: Thomas Solacroup, Matthieu Stettler, Hervé Broly
  • Methods for modifying glycosylation using manganese
    Patent number: 10519479
    Abstract: The present invention relates to a cell culture method for adjusting the proportion of G0, G1, G2, and high-mannose galactosylation variants in a population of a recombinant protein produced by a culture of cells in a cell culture medium by supplementing the cell culture medium with manganese at one or more days of the cell culture method duration.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: December 31, 2019
    Assignee: ARES TRADING S.A.
    Inventors: Thomas Solacroup, Matthieu Stettler, Martin Jordan, Hervé Broly