Patents by Inventor Thomas Spangenberg
Thomas Spangenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240150720Abstract: The present invention relates to 3D cell cultures, which contains hepatic cells and are infected by a pathogen, methods for preparing such cell cultures and uses thereof.Type: ApplicationFiled: January 16, 2024Publication date: May 9, 2024Applicant: Merck Patent GmbHInventors: Thomas SPANGENBERG, Beatrice Greco, Paula Maria Marques Leal Sanches Alves, Manuel José Teixeira Carrondo, Ana Catarina Mauricio Brito Ataíde, Sofia Raquel Paulo Rebelo, Francisca Maria De Andrade Terras Arez, Daniel Filipe Mestre Simão, Rui Miguel Prudêncio Pignatelli, Diana Marisa Pinto Freire Fontinha, Marta Monteiro Maia Machado
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Publication number: 20230301981Abstract: Compounds disclosed herein and pharmaceutically acceptable compositions thereof are useful as TLR7/8 antagonists.Type: ApplicationFiled: June 1, 2021Publication date: September 28, 2023Applicant: Merck Patent GmbHInventors: Lukas Shinji Okitsu, Julie DeMartino, Thomas Spangenberg
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Patent number: 11491162Abstract: A combination includes as a first active ingredient 6-fluoro-2-(4-morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide or a prodrug or pharmaceutically acceptable salt thereof and as a second active ingredient pyronaridine or a prodrug or pharmaceutically acceptable salt thereof. Also, a combination includes three antimalarial active ingredients, namely of 6-fluoro-2-(4-morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide or a prodrug or salt thereof, pyronaridine or pharmaceutically acceptable salt thereof, and artemisinin or derivatives thereof. Further, pharmaceutical compositions include such combination. The combinations and pharmaceutical compositions are useful for the treatment and/or prevention of malaria.Type: GrantFiled: April 9, 2019Date of Patent: November 8, 2022Assignee: Merck Patent GmbHInventors: Thomas Spangenberg, Claude Oeuvray, Nada Abla
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Publication number: 20210130790Abstract: 3D cell cultures contain hepatic cells and are infected by a pathogen. Such cell cultures are prepared by, for example, inoculating a single-cell suspension containing hepatic cells expanded in a 2D culture in an agitation-based culture system. Next, the resulting cell culture is agitated at a given agitation rate. Then, the resulting 3D cell culture containing cell aggregates is incubated with a pathogen.Type: ApplicationFiled: March 8, 2018Publication date: May 6, 2021Applicant: Merck Patent GmbHInventors: Thomas Spangenberg, Beatrice Greco, Paula Maria Marques Leal Sanches Alves, Manuel José Teixeira Carrondo, Ana Catarina Maurício Brito Ataíde, Sofia Raquel Paulo Rebelo, Francisca Maria De Andrade Terras Arez, Daniel Filipe Mestre Simão, Rui Miguel Prudêncio Pignatelli, Diana Marisa Pinto Freire Fontinha, Marta Monteiro Maia Machado
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Publication number: 20210023087Abstract: A combination includes as a first active ingredient 6-fluoro-2-(4-morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide or a prodrug or pharmaceutically acceptable salt thereof and as a second active ingredient pyronaridine or a prodrug or pharmaceutically acceptable salt thereof. Also, a combination includes three antimalarial active ingredients, namely of 6-fluoro-2-(4-morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide or a prodrug or salt thereof, pyronaridine or pharmaceutically acceptable salt thereof, and artemisinin or derivatives thereof. Further, pharmaceutical compositions include such combination. The combinations and pharmaceutical compositions are useful for the treatment and/or prevention of malaria.Type: ApplicationFiled: April 9, 2019Publication date: January 28, 2021Applicant: Merck Patent GmbHInventors: Thomas Spangenberg, Claude Oeuvray, Nada Abla
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Azepanyl-derivatives and pharmaceutical compositions comprising the same with antiparasitic activity
Patent number: 9994577Abstract: The present invention provides compounds of Formula (i). Furthermore, pharmaceutical compositions are provided comprising at least one compound of Formula (i), for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases.Type: GrantFiled: July 6, 2015Date of Patent: June 12, 2018Assignee: MERCK PATENT GMBHInventor: Thomas Spangenberg -
Patent number: 9908863Abstract: The present invention provides compounds of Formula (I) for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases. Formula (I) wherein R3, R4, X and Y have the meaning given in claim 1.Type: GrantFiled: December 27, 2013Date of Patent: March 6, 2018Assignee: MERCK PATENT GMBHInventors: Julie Routier, Thomas Spangenberg
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AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY
Publication number: 20170137428Abstract: The present invention provides compounds of Formula (i). Furthermore, pharmaceutical compositions are provided comprising at least one compound of Formula (i), for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases.Type: ApplicationFiled: July 6, 2015Publication date: May 18, 2017Applicant: Merck Patent GmbHInventor: Thomas SPANGENBERG -
Publication number: 20150368226Abstract: The present invention provides compounds of Formula (I) for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases. Formula (I) wherein R3, R4, X and Y have the meaning given in claim 1.Type: ApplicationFiled: December 27, 2013Publication date: December 24, 2015Applicant: Merck Patent GmbHInventors: Julie ROUTIER, Thomas SPANGENBERG
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Publication number: 20050077146Abstract: An apparatus and method for diverting articles from a single lane to one of a plurality of lanes wherein the articles in the single lane are moving on a conveyor along a travel path, the apparatus comprising a pair of spaced apart flexible rails suspended above the conveyor where the flexible rails define a guide channel therebetween. The guide channel can have an upstream portion configured to receive the articles in the single lane and a downstream portion configured to distribute the articles to one of the lanes. The flexible rails are movable in a direction substantially parallel to the travel path. The downstream portion of the guide channel is configured to be selectively movable in a direction substantially perpendicular to the travel path in order to selectively distribute the articles to one of the lanes.Type: ApplicationFiled: August 10, 2004Publication date: April 14, 2005Inventors: Thomas Spangenberg, Carl Rakowski
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Patent number: 6772876Abstract: A chain link comprising an elongated body having opposed first and second ends defining a longitudinal axis therebetween. The body has guide shoes that project from a bottom portion of the body for supporting the link on a track. The chain link further includes a gripping member that has a structure that is in sliding engagement with a cooperating structure disposed along the body of the link. The cooperating structure permits the gripping member to move relative to the body in a direction parallel to the longitudinal axis of the body.Type: GrantFiled: July 2, 2002Date of Patent: August 10, 2004Assignee: AMBEC, Inc.Inventor: Thomas Spangenberg
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Patent number: 6772872Abstract: An apparatus and method for diverting articles from a single lane to one of a plurality of lanes wherein the articles in the single lane are moving on a conveyor along a travel path, the apparatus comprising a pair of spaced apart flexible rails suspended above the conveyor where the flexible rails define a guide channel therebetween. The guide channel can have an upstream portion configured to receive the articles in the single lane and a downstream portion configured to distribute the articles to one of the lanes. The flexible rails are movable in a direction substantially parallel to the travel path. The downstream portion of the guide channel is configured to be selectively movable in a direction substantially perpendicular to the travel path in order to selectively distribute the articles to one of the lanes.Type: GrantFiled: November 3, 2003Date of Patent: August 10, 2004Assignee: AMBEC, Inc.Inventors: Thomas Spangenberg, Carl Rakowski, Jr.
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Publication number: 20040129533Abstract: An apparatus and method for diverting articles from a single lane to one of a plurality of lanes wherein the articles in the single lane are moving on a conveyor along a travel path, the apparatus comprising a pair of spaced apart flexible rails suspended above the conveyor where the flexible rails define a guide channel therebetween. The guide channel can have an upstream portion configured to receive the articles in the single lane and a downstream portion configured to distribute the articles to one of the lanes. The flexible rails are movable in a direction substantially parallel to the travel path. The downstream portion of the guide channel is configured to be selectively movable in a direction substantially perpendicular to the travel path in order to selectively distribute the articles to one of the lanes.Type: ApplicationFiled: November 3, 2003Publication date: July 8, 2004Inventors: Thomas Spangenberg, Carl Rakowski
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Publication number: 20030047427Abstract: A chain link comprising an elongated body having opposed first and second ends defining a longitudinal axis therebetween. The body has guide shoes that project from a bottom portion of the body for supporting the link on a track. The chain link further includes a gripping member that has a structure that is in sliding engagement with a cooperating structure disposed along the body of the link. The cooperating structure permits the gripping member to move relative to the body in a direction parallel to the longitudinal axis of the body.Type: ApplicationFiled: July 2, 2002Publication date: March 13, 2003Inventor: Thomas Spangenberg
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Patent number: 6365906Abstract: The invention is directed to an apparatus for detecting and ejecting fallen containers on a conveyor line. The detecting apparatus includes at least three sensors arranged beside the conveyor system. Two of the sensors are positioned to detect the top of a container and a third sensor is positioned to detect the bottom of the container. When a container is judged to be fallen on the conveyor line, a control system sends a signal to an ejector apparatus to remove the fallen container from the conveyor line.Type: GrantFiled: July 22, 1999Date of Patent: April 2, 2002Assignee: AMBEC, IncorporatedInventors: Thomas Spangenberg, Thomas Lamb