Abstract: Compounds disclosed herein and pharmaceutically acceptable compositions thereof are useful as TLR7/8 antagonists.

Abstract: A combination includes as a first active ingredient 6-fluoro-2-(4-morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide or a prodrug or pharmaceutically acceptable salt thereof and as a second active ingredient pyronaridine or a prodrug or pharmaceutically acceptable salt thereof. Also, a combination includes three antimalarial active ingredients, namely of 6-fluoro-2-(4-morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide or a prodrug or salt thereof, pyronaridine or pharmaceutically acceptable salt thereof, and artemisinin or derivatives thereof. Further, pharmaceutical compositions include such combination. The combinations and pharmaceutical compositions are useful for the treatment and/or prevention of malaria.

Abstract: 3D cell cultures contain hepatic cells and are infected by a pathogen. Such cell cultures are prepared by, for example, inoculating a single-cell suspension containing hepatic cells expanded in a 2D culture in an agitation-based culture system. Next, the resulting cell culture is agitated at a given agitation rate. Then, the resulting 3D cell culture containing cell aggregates is incubated with a pathogen.

Abstract: A combination includes as a first active ingredient 6-fluoro-2-(4-morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide or a prodrug or pharmaceutically acceptable salt thereof and as a second active ingredient pyronaridine or a prodrug or pharmaceutically acceptable salt thereof. Also, a combination includes three antimalarial active ingredients, namely of 6-fluoro-2-(4-morpholin-4-ylmethyl-phenyl)-quinoline-4-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide or a prodrug or salt thereof, pyronaridine or pharmaceutically acceptable salt thereof, and artemisinin or derivatives thereof. Further, pharmaceutical compositions include such combination. The combinations and pharmaceutical compositions are useful for the treatment and/or prevention of malaria.

Abstract: The present invention provides compounds of Formula (i). Furthermore, pharmaceutical compositions are provided comprising at least one compound of Formula (i), for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases.

Abstract: The present invention provides compounds of Formula (I) for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases. Formula (I) wherein R3, R4, X and Y have the meaning given in claim 1.

Abstract: The present invention provides compounds of Formula (i). Furthermore, pharmaceutical compositions are provided comprising at least one compound of Formula (i), for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases.

Abstract: The present invention provides compounds of Formula (I) for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases. Formula (I) wherein R3, R4, X and Y have the meaning given in claim 1.

Abstract: An apparatus and method for diverting articles from a single lane to one of a plurality of lanes wherein the articles in the single lane are moving on a conveyor along a travel path, the apparatus comprising a pair of spaced apart flexible rails suspended above the conveyor where the flexible rails define a guide channel therebetween. The guide channel can have an upstream portion configured to receive the articles in the single lane and a downstream portion configured to distribute the articles to one of the lanes. The flexible rails are movable in a direction substantially parallel to the travel path. The downstream portion of the guide channel is configured to be selectively movable in a direction substantially perpendicular to the travel path in order to selectively distribute the articles to one of the lanes.

Abstract: An apparatus and method for diverting articles from a single lane to one of a plurality of lanes wherein the articles in the single lane are moving on a conveyor along a travel path, the apparatus comprising a pair of spaced apart flexible rails suspended above the conveyor where the flexible rails define a guide channel therebetween. The guide channel can have an upstream portion configured to receive the articles in the single lane and a downstream portion configured to distribute the articles to one of the lanes. The flexible rails are movable in a direction substantially parallel to the travel path. The downstream portion of the guide channel is configured to be selectively movable in a direction substantially perpendicular to the travel path in order to selectively distribute the articles to one of the lanes.

Abstract: A chain link comprising an elongated body having opposed first and second ends defining a longitudinal axis therebetween. The body has guide shoes that project from a bottom portion of the body for supporting the link on a track. The chain link further includes a gripping member that has a structure that is in sliding engagement with a cooperating structure disposed along the body of the link. The cooperating structure permits the gripping member to move relative to the body in a direction parallel to the longitudinal axis of the body.

Abstract: An apparatus and method for diverting articles from a single lane to one of a plurality of lanes wherein the articles in the single lane are moving on a conveyor along a travel path, the apparatus comprising a pair of spaced apart flexible rails suspended above the conveyor where the flexible rails define a guide channel therebetween. The guide channel can have an upstream portion configured to receive the articles in the single lane and a downstream portion configured to distribute the articles to one of the lanes. The flexible rails are movable in a direction substantially parallel to the travel path. The downstream portion of the guide channel is configured to be selectively movable in a direction substantially perpendicular to the travel path in order to selectively distribute the articles to one of the lanes.

Abstract: A chain link comprising an elongated body having opposed first and second ends defining a longitudinal axis therebetween. The body has guide shoes that project from a bottom portion of the body for supporting the link on a track. The chain link further includes a gripping member that has a structure that is in sliding engagement with a cooperating structure disposed along the body of the link. The cooperating structure permits the gripping member to move relative to the body in a direction parallel to the longitudinal axis of the body.

Abstract: The invention is directed to an apparatus for detecting and ejecting fallen containers on a conveyor line. The detecting apparatus includes at least three sensors arranged beside the conveyor system. Two of the sensors are positioned to detect the top of a container and a third sensor is positioned to detect the bottom of the container. When a container is judged to be fallen on the conveyor line, a control system sends a signal to an ejector apparatus to remove the fallen container from the conveyor line.