Patents by Inventor Thomas Spires

Thomas Spires has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying or screening for agents that modulate 17?-HSD3
    Patent number: 7138246
    Abstract: Methods for determining whether a test agent inhibits a 17?-HSD3, the methods comprising: obtaining a recombinant host cell that expresses the 17?-HSD3; obtaining a reaction mixture comprising the 17?-HSD3, androstenedione, and the test agent; measuring the amount of testosterone in the reaction mixture by a scintillation proximity assay (SPA) using SPA beads conjugated with a testosterone-specific antibody, wherein when the amount of testosterone is lower in the presence of a test agent than in the absence of the test agent, the test agent is identified as an inhibitor of the 17?-HSD3.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: November 21, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Matthew V. Lorenzi, Thomas Spires, Dan You, Roberto Weinmann, Marco Gottardis
  • Methods for identifying or screening for agents that modulate 17beta-HSD3
    Publication number: 20050191707
    Abstract: Methods for determining whether a test agent inhibits a 17?-HSD3, said methods comprising: obtaining a recombinant host cell that expresses said 17?-HSD3; obtaining a reaction mixture comprising said 17?-HSD3, androstenedione, and said test agent; measuring the amount of testosterone in said reaction mixture by a scintillation proximity assay (SPA) using SPA beads conjugated with a testosterone-specific antibody, wherein when the amount of testosterone is lower in the presence of a test agent than in the absence of the test agent, the test agent is identified as an inhibitor of said 17?-HSD3.
    Type: Application
    Filed: February 28, 2005
    Publication date: September 1, 2005
    Inventors: Matthew Lorenzi, Thomas Spires, Dan You, Roberto Weinmann, Marco Gottardis