Abstract: Provided herein are compositions and methods for the treatment of cancer by inhibition of ?-catenin or a ?-catenin pathway. In particular, inhibitors of ?-catenin and/or the Wnt/?-catenin signaling pathway are employed prevent or reverse evasion of immune response or immunotherapy by cancers.

Abstract: An evaporator with a finned tube block with tubes and fins, wherein the tubes are arranged in rows and the fins are arranged between the tubes, with a first collection and distribution box and with a second collection and distribution box. Each of the two collection and distribution boxes has a bottom and a box lid. The respective bottom has openings for inserting the tube ends of the tubes of the finned tube block. The finned tube block is divided into evaporator flows to which groups of tubes of the finned tube block are assigned. The tubes of an evaporator flow each merge end-side into a box area of a collection and distribution box. The respective bottom of the collection and distribution boxes is designed with rim holes for inserting the tube ends in the openings.

Abstract: A heat exchanger having at least one electrical resistance heating element, two conductors connected electrically to the electrical resistance heating element to conduct electric current through the electrical resistance heating element and thereby to heat the electrical resistance heating element, a heat-conducting element for transferring heat from the electrical resistance heating element to a fluid to be heated, an electrical insulating element insulating electrically the two conductors and the at least one electrical resistance heating element, and at least one tube. The two conductors, the electrical insulating element, and the electrical resistance heating element are arranged within a cavity bounded by the tube. The heat exchanger has an adapter plate and a tube opening, each being arranged at an opening of the adapter plate, and the at least one tube being connected fluid-tight to the adapter plate, which is connected fluid-tight to an electronics housing and/or an HVAC system housing.

Abstract: Disclosed herein is a heat exchanger, comprising at least one electric resistance heating element, at least two conductors which are connected to the at least one electric resistance heating element in an electrically conductive manner in order to conduct electric current through the at least one electric resistance heating element and thereby heat the electric resistance heating element, at least one thermally conductive element for transferring heat from the at least one electric resistance heating element to a fluid to be heated, at least one electrically insulating element, which electrically insulates the at least two conductors, and at least one pipe, wherein the at least two conductors and the at least one electric resistance heating element are arranged within a cavity bounded by the pipe and the pipe lies on the at least one electrically insulating element under a compressive force at at least one contact surface.

Abstract: The invention relates to an electrically operable heating device through which liquid flows, comprising a housing. The heating device comprises an electrically operable heating apparatus and a liquid chamber for accommodating a heat-transferring liquid. The liquid chamber has a plurality of plate pairs comprising plates connected to each other at specified distances from each other, whereby liquid flow channels can be created between the plate pairs. The electrically operable heating apparatus is designed as a heating combination having a plurality of heating elements, wherein the heating combination can be arranged between the liquid chambers by inserting the heating units into the accommodating spaces produced between the plate pairs.

Abstract: The invention relates to an electrically operable heating device through which liquid flows, comprising a housing. The heating device comprises an electrically operable heating apparatus and a liquid chamber for accommodating a heat-transferring liquid. The liquid chamber has a plurality of plate pairs comprising plates connected to each other at specified distances from each other, whereby liquid flow channels can be created between the plate pairs. The electrically operable heating apparatus is designed as a heating combination having a plurality of heating elements, wherein the heating combination can be arranged between the liquid chambers by inserting the heating units into the accommodating spaces produced between the plate pairs.

Abstract: Disclosed herein is a heat exchanger, comprising at least one electric resistance heating element, at least two conductors which are connected to the at least one electric resistance heating element in an electrically conductive manner in order to conduct electric current through the at least one electric resistance heating element and thereby heat the electric resistance heating element, at least one thermally conductive element for transferring heat from the at least one electric resistance heating element to a fluid to be heated, at least one electrically insulating element, which electrically insulates the at least two conductors, and at least one pipe, wherein the at least two conductors and the at least one electric resistance heating element are arranged within a cavity bounded by the pipe and the pipe lies on the at least one electrically insulating element under a compressive force at at least one contact surface.

Abstract: A heat exchanger having at least one electrical resistance heating element, two conductors connected electrically to the electrical resistance heating element to conduct electric current through the electrical resistance heating element and thereby to heat the electrical resistance heating element, a heat-conducting element for transferring heat from the electrical resistance heating element to a fluid to be heated, an electrical insulating element insulating electrically the two conductors and the at least one electrical resistance heating element, and at least one tube. The two conductors, the electrical insulating element, and the electrical resistance heating element are arranged within a cavity bounded by the tube. The heat exchanger has an adapter plate and a tube opening, each being arranged at an opening of the adapter plate, and the at least one tube being connected fluid-tight to the adapter plate, which is connected fluid-tight to an electronics housing and/or an HVAC system housing.

Abstract: The invention relates to an air conditioner of an air conditioning system of a vehicle, comprising a housing with a removable housing cover, in which the following components are arranged: at least one blower motor, at least one impeller, at least one blower motor mounting and at least one motor regulator. According to the invention, said components are arranged in cover (1) of the housing, especially in the inner side (3) thereof.

Abstract: A heating or air conditioning unit for the interior of a motor vehicle including installation frames having louvers being inserted into a receptacle of the housing provided for that purpose. The installation frame has a profile on its frame sides so that the installation frame is held in a positive-locking manner in a receptacle of the housing. The profile has a wedge-shaped structure, thin ribs extending, running apart, along a frame side in the insertion direction.