Patents by Inventor Thomas Steitz

Thomas Steitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RIBOSOME STRUCTURE AND PROTEIN SYNTHESIS INHIBITORS
    Publication number: 20150258092
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: November 25, 2014
    Publication date: September 17, 2015
    Applicants: YALE UNIVERSITY, MELINTA THERAPEUTICS, INC.
    Inventors: Thomas Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • Ribosome Structure and Protein Synthesis Inhibitors
    Publication number: 20100204253
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: December 23, 2009
    Publication date: August 12, 2010
    Applicants: Yale University, Rib-X Pharmaceuticals, Inc.
    Inventors: Thomas Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
  • MODULATORS OF RIBOSOMAL FUNCTION AND IDENTIFICATION THEREOF
    Publication number: 20060136146
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: September 29, 2005
    Publication date: June 22, 2006
    Inventors: Thomas Steitz, Peter Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
  • Ribosome structure and protein synthesis inhibitors
    Publication number: 20050272681
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: February 25, 2005
    Publication date: December 8, 2005
    Applicants: Yale University, Rib-X Pharmaceuticals
    Inventors: Thomas Steitz, Peter Moore, Joyce Sutcliffe, Adegboyega Oyelere, Joseph Ippolito
  • Ribosome structure and protein synthesis inhibitors
    Publication number: 20050234227
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: August 9, 2004
    Publication date: October 20, 2005
    Applicant: Yale University
    Inventors: Thomas Steitz, Peter Moore, Nenad Ban, Poul Nissen, Jeffrey Hansen
  • RIBOSOME STRUCTURE AND PROTEIN SYNTHESIS INHIBITORS
    Publication number: 20050036997
    Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
    Type: Application
    Filed: August 2, 2002
    Publication date: February 17, 2005
    Applicants: Yale University, Rib-X Pharmaceuticals, Inc.
    Inventors: Thomas Steitz, Peter Moore, Joyce Sutcliffe, Adegboyega Oyelere, Joseph Ippolito