Patents by Inventor Thomas Stoddard

Thomas Stoddard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant plant or cell with reduced XylT and FucT
    Patent number: 11576317
    Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: February 14, 2023
    Assignees: CELLECTIS SA, MEDICAGO INC.
    Inventors: Luc Mathis, Daniel F. Voytas, Jin Li, Feng Zhang, Thomas Stoddard, Marc-Andre D'Aoust
  • Method for making nicotiana plants with mutations in XylT and FucT alleles using rare-cutting endonucleases
    Patent number: 11555198
    Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: January 17, 2023
    Assignees: CELLECTIS SA, MEDICAGO INC.
    Inventors: Luc Mathis, Daniel F. Voytas, Jin Li, Feng Zhang, Thomas Stoddard, Marc-Andre D'Aoust
  • PLANTS FOR PRODUCTION OF THERAPEUTIC PROTEINS
    Publication number: 20210059142
    Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
    Type: Application
    Filed: November 13, 2020
    Publication date: March 4, 2021
    Inventors: Luc Mathis, Daniel F. Voytas, Jin Li, Feng Zhang, Thomas Stoddard, Marc-Andre D'Aoust
  • METHODS FOR NON-TRANSGENIC GENOME EDITING IN PLANTS
    Publication number: 20210002656
    Abstract: Materials and methods for creating genome-engineered plants with non-transgenic methods are provided herein.
    Type: Application
    Filed: September 16, 2020
    Publication date: January 7, 2021
    Inventors: Daniel F. Voytas, Feng Zhang, Jin Li, Thomas Stoddard, Song Luo
  • Modifying messenger RNA stability in plant transformations
    Patent number: 10837024
    Abstract: Materials and methods for genome engineering through transient expression of a targeted nuclease are described herein. For example, the methods described herein can include introducing into a cell a messenger RNA (mRNA) that encodes a nuclease targeted to a selected sequence within the cell, where the stability of the mRNA is modified by the addition of untranslated regions (UTRs).
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: November 17, 2020
    Assignee: CELLECTIS
    Inventors: Thomas Stoddard, Song Luo
  • POTATOES WITH REDUCED COLD-INDUCED SWEETENING
    Publication number: 20200157525
    Abstract: Materials and methods are provided for making plants (e.g., Solanum varieties) with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
    Type: Application
    Filed: October 25, 2019
    Publication date: May 21, 2020
    Inventors: Luc Mathis, Daniel F. Voytas, Feng Zhang, Benjamin Clasen, William Haun, Thomas Stoddard
  • Potatoes with reduced cold-induced sweetening
    Patent number: 10513698
    Abstract: Materials and methods are provided for making Solanum varieties with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: December 24, 2019
    Assignee: CELLECTIS
    Inventors: Luc Mathis, Daniel F. Voytas, Feng Zhang, Benjamin Clasen, William Haun, Thomas Stoddard
  • POTATOES WITH REDUCED COLD-INDUCED SWEETENING
    Publication number: 20170258024
    Abstract: Materials and methods are provided for making plants (e.g., Solanum varieties) with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
    Type: Application
    Filed: October 25, 2016
    Publication date: September 14, 2017
    Inventors: Luc Mathis, Daniel F. Voytas, Feng Zhang, Benjamin Clasen, William Haun, Thomas Stoddard
  • MODIFYING MESSENGER RNA STABILITY IN PLANT TRANSFORMATIONS
    Publication number: 20170081672
    Abstract: Materials and methods for genome engineering through transient expression of a targeted nuclease are described herein. For example, the methods described herein can include introducing into a cell a messenger RNA (mRNA) that encodes a nuclease targeted to a selected sequence within the cell, where the stability of the mRNA is modified by the addition of untranslated regions (UTRs).
    Type: Application
    Filed: February 29, 2016
    Publication date: March 23, 2017
    Inventors: Thomas Stoddard, Song Luo
  • AGROBACTERIUM-MEDIATED GENOME MODIFICATION WITHOUT T-DNA INTEGRATION
    Publication number: 20160222395
    Abstract: Methods for genome engineering, including methods utilizing transient expression of a nuclease utilizing modified transfer-DNA (T-DNA) plasmids, are provided herein.
    Type: Application
    Filed: February 2, 2016
    Publication date: August 4, 2016
    Inventors: Thomas Stoddard, Nicholas J. Baltes, Song Luo
  • METHODS FOR NON-TRANSGENIC GENOME EDITING IN PLANTS
    Publication number: 20160145631
    Abstract: Materials and methods for creating genome-engineered plants with non-transgenic methods are provided herein.
    Type: Application
    Filed: June 13, 2014
    Publication date: May 26, 2016
    Inventors: Daniel F. Voytas, Feng Zhang, Jin Li, Thomas Stoddard, Song Luo
  • BRASSICA ENGINEERED TO CONFER HERBICIDE TOLERANCE
    Publication number: 20160138040
    Abstract: Materials and methods for making plants (e.g., Brassica varieties) with tolerance to ALS-inhibiting herbicides are provided herein. The methods can include making mutations in the gene encoding acetolactate synthase (ALS)/acetohydroxyacid synthase (AHAS), where the mutations are induced using a rare-cutting endonuclease and a donor matrix.
    Type: Application
    Filed: November 13, 2015
    Publication date: May 19, 2016
    Inventors: Daniel F. Voytas, Thomas Stoddard, Feng Zhang, Luc Mathis
  • POTATOES WITH REDUCED COLD-INDUCED SWEETENING
    Publication number: 20160037742
    Abstract: Materials and methods are provided for making Solanum varieties with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
    Type: Application
    Filed: December 20, 2013
    Publication date: February 11, 2016
    Inventors: Luc Mathis, Daniel F. Voytas, Feng Zhang, Benjamin Clasen, William Haun, Thomas Stoddard
  • PLANTS FOR PRODUCTION OF THERAPEUTIC PROTEINS
    Publication number: 20150272076
    Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
    Type: Application
    Filed: October 31, 2013
    Publication date: October 1, 2015
    Inventors: Luc Mathis, Daniel F. Voytas, Jin Li, Feng Zhang, Thomas Stoddard, Marc-Andre D'Aoust
  • POTATOES WITH REDUCED COLD-INDUCED SWEETENING
    Publication number: 20140178561
    Abstract: Materials and methods are provided for making plants (e.g., Solanum varieties) with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 26, 2014
    Applicant: Cellectis
    Inventors: Luc Mathis, Daniel F. Voytas, Feng Zhang, Benjamin Clasen, William Haun, Thomas Stoddard
  • PLANTS FOR PRODUCTION OF THERAPEUTIC PROTEINS
    Publication number: 20140120578
    Abstract: Materials and Methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
    Type: Application
    Filed: October 31, 2013
    Publication date: May 1, 2014
    Applicants: Medicago Inc., Cellectis SA
    Inventors: Luc Mathis, Daniel F. Voytas, Jin Li, Feng Zhang, Thomas Stoddard, Marc-André D'Aoust