Abstract: The present disclosure relates to a sealing assembly for sealing a space between a first machine element and a second machine element that is movable in relation to the first machine element. The first and second machine elements are arranged concentrically to each other. According to the invention, the sealing assembly is characterized in that it further comprises a conductive element that is used to establish an electrically conductive connection between the first and the second machine elements extending from the first machine element to the second machine element, and is mechanically connected at least in sections to the side of the seal facing away from the space to be sealed. The conductive element consists of an electrically conductive fiber fabric embedded in an elastomer matrix.

Abstract: The present invention relates to Orally Inhaled and Nasal Drug Product (OINDP) comprising a benzodiazepine, in particular remimazolam.

Abstract: The present invention relates to a separator plate for an electro-chemical system. The separator plate comprises: a first passage; an active region with structures for guiding a reaction medium along a first flat face of the separator plate and guiding a coolant along a rear face of the active region on the second flat face of the separator plate; a bead formed in the separator plate for sealing at least the active region; and barrier elements formed in the separator plate, which reduce or prevent a flow of reaction medium on the first flat face of the separator plate along the bead and past the active region. The separator plate fully encloses the first passage and the active region together and that at least one of the barrier elements is at least in parts sunk.

Abstract: A drive apparatus for a closure element of a motor vehicle, including a tube defining an axis, a spindle disposed within the tube and configured to translate along the axis from an extended position to a first retracted position and a second retracted position, a spindle nut disposed within the tube and operatively engaged to the spindle, a stop nut fixed to the spindle, and a damping element disposed between the spindle nut and the stop nut. The tube defines a first end stop face and the stop nut defines a second end stop face, and when the spindle is in the first retracted position, the damping element engages the first end stop face and is spaced apart from the stop nut.

Abstract: The present disclosure relates to a sealing assembly for sealing a space between a first machine element and a second machine element that is movable in relation to the first machine element. The first and second machine elements are arranged concentrically to each other. According to the invention, the sealing assembly is characterized in that it further comprises a conductive element that is used to establish an electrically conductive connection between the first and the second machine elements extending from the first machine element to the second machine element, and is mechanically connected at least in sections to the side of the seal facing away from the space to be sealed. The conductive element consists of an electrically conductive fiber fabric embedded in an elastomer matrix.

Abstract: The present invention relates to Orally Inhaled and Nasal Drug Product (OINDP) comprising a benzodiazepine, in particular remimazolam.

Abstract: The present invention relates to a separator plate for an electro-chemical system. The separator plate comprises: a first passage; an active region with structures for guiding a reaction medium along a first flat face of the separator plate and guiding a coolant along a rear face of the active region on the second flat face of the separator plate; a bead formed in the separator plate for sealing at least the active region; and barrier elements formed in the separator plate, which reduce or prevent a flow of reaction medium on the first flat face of the separator plate along the bead and past the active region. The separator plate fully encloses the first passage and the active region together and that at least one of the barrier elements is at least in parts sunk.

Abstract: The present invention relates to Orally Inhaled and Nasal Drug Product (OINDP) comprising a benzodiazepine, in particular remimazolam.

Abstract: The present invention is directed to a pharmaceutical composition comprising a Compound (a) of a class of peptide Compounds and at least one further Compound (b) for the prevention, alleviation or/and treatment of epileptic seizures.

Abstract: The present invention is directed to a pharmaceutical composition comprising a Compound (a) of a class of peptide Compounds and at least one further Compound (b) for the prevention, alleviation or/and treatment of epileptic seizures.

Abstract: The present invention is directed to a pharmaceutical composition comprising a Compound (a) of a class of peptide Compounds and at least one further Compound (b) for the prevention, alleviation or/and treatment of epileptic seizures.

Abstract: A method for alleviating and/or treating epileptic seizures comprising administering a pharmaceutical composition comprising (a) lacosamide and/or a pharmaceutically acceptable salt thereof; and (b) levetiracetam and/or a pharmaceutically acceptable salt thereof is described.

Abstract: A method of treating inflammatory diseases with Adenosine 2B receptor antagonists in particular with xanthine derived inhibitors. The method involves supplying a therapeutically active amount of the compounds of FIG. 1 and in particular compound 1.

Abstract: The present invention is directed to the use of a class of peptide Compounds for prevention, alleviation or/and treatment of refractory Status epilepticus.

Abstract: The present invention is directed to the use of a class of peptide Compounds for prevention, alleviation or/and treatment of refractory Status epilepticus.

Abstract: The present invention is directed to a pharmaceutical composition comprising a Compound (a) of a class of peptide Compounds and at least one further Compound (b) for the prevention, alleviation or/and treatment of epileptic seizures.

Abstract: The present invention is directed to the use of a class of peptide compounds for treating tumor pain, in particular bone cancer pain, for treating chemotherapy-induced pain and for treating nucleoside-induced pain.

Abstract: The present invention is directed to the use of a class of peptide compounds for treating pain in trigeminal neuralgia.

Abstract: The present invention is directed to a pharmaceutical composition comprising a Compound (a) of a class of peptide Compounds and at least one further Compound (b) for the prevention, alleviation or/and treatment of epileptic seizures.

Abstract: An embodiment of the present invention relates to a therapeutic combination including (a) lacosamide and/or a pharmaceutically acceptable salt thereof; and (b) levetiracetam and/or a pharmaceutically acceptable salt thereof. The combination can be provided in a single dosage form or separate dosage forms.