Patents by Inventor Thomas Stormann

Thomas Stormann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
    Patent number: 7585881
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Grant
    Filed: February 9, 2005
    Date of Patent: September 8, 2009
    Assignee: AstraZeneca AB
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tau Xin, Jalaj Arora
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20080045571
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: February 21, 2008
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20080015234
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: January 17, 2008
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20080015204
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: January 17, 2008
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
    Publication number: 20070293545
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: August 18, 2007
    Publication date: December 20, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • 5-Fluoro-, Chloro-and Cyano-Pyridin-2-Yl-Tetrazoles as Ligands of the Metabotropic Glutamate Receptor-5
    Publication number: 20070255061
    Abstract: The present invention relates to new compounds of formula I, wherein Z, Q, X1, X2, R1 and R2, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: December 13, 2004
    Publication date: November 1, 2007
    Applicants: AstraZeneca AB, NPS Pharmaceuticals, Inc.
    Inventors: David Wensbo, Louise Edwards, Methvin Isaac, Donald McLeod, Abdelmalik Slassi, Tao Xin, Thomas Stormann
  • Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20070179188
    Abstract: The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: February 15, 2005
    Publication date: August 2, 2007
    Applicants: AstraZeneca AB, NPS PHARMACEUTICALS, INC.
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald Mcleod, Alexander Minidis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20060189661
    Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
    Type: Application
    Filed: April 6, 2006
    Publication date: August 24, 2006
    Inventors: Bradford Wagenen, Thomas Stormann, Scott Moe, Susan Sheehan, Donald McLeod, Daryl Smith, Methvin Isaac, Abdelmalik Slassi, Ian Egle, Louise Edwards, Tomislav Stefanac, Tao Xin, Jalaj Arora, William Michne
  • Use of mglur5 antagonists for the treatment of gerd
    Publication number: 20060128760
    Abstract: The present invention relates to the use of metabotropic glutamate receptor 5 antagonists for the inhibition of transient lower esophageal sphincter relaxations. A further aspects of the invention is directed to the use of metabotropic glutamate receptor 5 antagonists for the treatment of gastro, esophageal reflux disease, as well as for the treatment of regurgitation and asthma.
    Type: Application
    Filed: June 19, 2003
    Publication date: June 15, 2006
    Inventors: Anders Lehmann, Jan Mattson, Thomas Stormann
  • Compounds
    Publication number: 20060122397
    Abstract: The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: November 14, 2005
    Publication date: June 8, 2006
    Applicants: AstraZeneca AB, NPS Pharmaceutical
    Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Donald McLeod, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Helena Gyback, Martin Johansson, Annika Kers, John Malmberg, Alexander Minidis, Karin Oscarsson, Mangus Waldman, Ulrika Yngve, Christoffer Osterwall
  • New compounds
    Publication number: 20060063772
    Abstract: The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, X4, R, R1, R2, R3, R4, R5, R6, R7, m, n, o, p and q are defined as in any one of claims 1 to 12, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
    Type: Application
    Filed: November 10, 2005
    Publication date: March 23, 2006
    Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Donald McLeod, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Annika Kers, Johan Malmberg, Karin Oscarsson
  • Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20050272779
    Abstract: The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
    Type: Application
    Filed: February 9, 2005
    Publication date: December 8, 2005
    Inventors: Louise Edwards, Methvin Isaac, Martin Johansson, Annika Kers, Johan Malmberg, Donald McLeod, Alexander Mindis, Karin Staaf, Abdelmalik Slassi, Tomislav Stefanac, Thomas Stormann, David Wensbo, Tao Xin, Jalaj Arora
  • Chimeric metabotropic glutamate receptors and uses thereof
    Publication number: 20050186658
    Abstract: The present invention provides chimeric receptors that include an extracellular domain from a metabotropic glutamate receptor and a non-native signal peptide, e.g., a calcium receptor signal peptide. The invention also includes methods of preparing such chimeric receptors, and methods of using such receptors to identify and characterize compounds which modulate the activity of metabotropic glutamate receptors. The invention also relates to compounds and methods for modulating metabotropic glutamate receptor activity and binding to metabotropic glutamate receptors. Modulation of metabotropic glutamate receptor activity can be used for different purposes such as treating neurological disorders and diseases, inducing an analgesic effect, cognition enhancement, and inducing a muscle-relaxant effect.
    Type: Application
    Filed: October 15, 2004
    Publication date: August 25, 2005
    Inventors: Ashwani Gupta, Pamela Jacobson, Keith Jarvie, Karen Krapcho, Laura Storjohann, Thomas Stormann
  • Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
    Publication number: 20050154027
    Abstract: The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
    Type: Application
    Filed: November 3, 2003
    Publication date: July 14, 2005
    Inventors: Bradford Wagenen, Thomas Stormann, Scott Moe, Susan Sheehan, Donald McLeod, Daryl Smith, Methvin Isaac, Abdelmalik Slassi