Patents by Inventor Thomas Stossel

Thomas Stossel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF GELSOLIN TO TREAT INFECTIONS
    Publication number: 20080118945
    Abstract: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.
    Type: Application
    Filed: January 23, 2008
    Publication date: May 22, 2008
    Inventors: Thomas Stossel, Po-Shun Lee
  • Methods of Using Gelsolin to Treat or Prevent Bacterial Sepsis
    Publication number: 20070238655
    Abstract: Provided are methods of using gelsolin and active fragments thereof to neutralize, treat or prevent the pathogenic effects of lipopolysaccharide (LPS) endotoxins released from gram-negative bacteria, including massive activation of inflammatory response in a patient and the resulting lethal septic shock. The provided gelsolin binds LPS from various bacteria with high affinity, decreasing circulating LPS and neutralizes its deleterious biological effects. Consequently, the provided gelsolin replacement therapy offers a method for the prevention of LPS-induced mortality in the patient.
    Type: Application
    Filed: November 12, 2004
    Publication date: October 11, 2007
    Inventors: Robert Bucki, Paul Janmey, Richard Chaby, Thomas Stossel
  • Use of gelsolin to treat infections
    Publication number: 20060009386
    Abstract: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.
    Type: Application
    Filed: May 12, 2005
    Publication date: January 12, 2006
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Thomas Stossel, Po-Shun Lee