Patents by Inventor Thomas Suchyna

Thomas Suchyna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compound to inhibit Ca permeable cation conductance
    Patent number: 9211313
    Abstract: The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: December 15, 2015
    Assignees: The Research Foundation of State University of New York, Beth Israel Deaconess Medical Center
    Inventors: Frederick Sachs, Philip Gottlieb, Thomas Suchyna, Seth L. Alper, David H. Vandorpe, Chang Xu
  • Methods and Compound to Inhibit Ca2+ Permeable Cation Conductance
    Publication number: 20120184491
    Abstract: The present invention provides methods and compositions for inhibiting calcium permeable cation conductance of red blood cells from individuals afflicted with sickle cell anemia. The method comprises exposing the cells to the peptide GsMTx4 and/or variants thereof.
    Type: Application
    Filed: January 17, 2012
    Publication date: July 19, 2012
    Inventors: Frederick Sachs, Philip Gottlieb, Thomas Suchyna, Seth L. Alper, David H. Vandorpe, Chang Xu
  • Mechanically activated channel blocker
    Patent number: 7259145
    Abstract: The present invention discloses a peptide of SEQ ID NO:1 and its variants that blocks stretch-activated ion channels. All amino acids in this peptide are D-amino acids. The peptide, designated as D-GsMTx4, is an enantiomer of a peptide GsMTX-4 present in the venom of the spider Grammostola spatulata. The present invention also discloses a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias and other pathologies that involve alterations in mechanical stress.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: August 21, 2007
    Assignee: The Research Foundation of State University of New York
    Inventors: Frederick Sachs, Thomas Suchyna, Phillip Gottlieb
  • Mechanically activated channel blocker
    Patent number: 7125847
    Abstract: The present invention discloses a peptide of SEQ ID NO:2 and its variants that blocks stretch-activated ion channels. The peptide, designated as GsMTx-4, is present in the venom of the spider Grammostola spatulata. The present invention also discloses a method of purifying the peptide GsMTx-4 from the spider venom and a method for inhibition of stretch activated ion channels in a cell. The cDNA sequence encoding the GsMTx-4 is also disclosed. This peptide and its variants can be used for the treatment of cardiac arrhythmias.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: October 24, 2006
    Assignee: The Research Foundation of State University of New York at Buffalo
    Inventors: Frederick Sachs, Thomas Suchyna, Janice Johnson
  • Mechanically activated channel blocker
    Publication number: 20060014691
    Abstract: The present invention discloses a peptide of SEQ ID NO:1 and its variants that blocks stretch-activated ion channels. All amino acids in this peptide are D-amino acids. The peptide, designated as D-GsMTx4, is an enantiomer of a peptide GsMTX-4 present in the venom of the spider Grammostola spatulata. The present invention also discloses a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias and other pathologies that involve alteartions in mechanical stress.
    Type: Application
    Filed: July 7, 2005
    Publication date: January 19, 2006
    Inventors: Frederick Sachs, Thomas Suchyna, Phillip Gottlieb
  • Mechanically activated channel blocker
    Publication number: 20020077286
    Abstract: The present invention discloses a 35 amino acid peptide (SEQ ID NO: 1) that blocks stretch-activated ion channels. The peptide, designated as GsMTx-4, is present in the venom of the spider Grammostola spatulata. The present invention also discloses a method of purifying the peptide GsMTx-4 from the spider venom and a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias.
    Type: Application
    Filed: April 6, 2001
    Publication date: June 20, 2002
    Inventors: Frederick Sachs, Janice H. Johnson, Thomas Suchyna