Abstract: This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells.

Abstract: This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentration of reduced nicotinamide adenine dinucleotide (NADH) in the cell.

Abstract: This invention provides methods for alleviating paroxysmal disorders in an animal, particularly epilepsy, by modulating glycolysis in brain cells.

Abstract: A number of molecules, including genes, gene fragments and encoded gene products which play key roles in function and outcome after initial neuronal injury are disclosed. The disclosed molecules include genes with an association with neural plasticity. The disclosed molecules, as well as the expression patterns associated with these molecules as a group, are used to advantage in a variety of assays for the identification of therapeutic agents to treat epilepsy and other conditions that also involve plasticity of neural circuits, such as stroke, trauma and neurodegenerative diseases. Compositions comprising the disclosed molecules and diagnostic methods, prognostic agents, and test kits in connection with such conditions are also disclosed.