Patents by Inventor Thomas Svab

Thomas Svab has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polysaccharide-protein conjugates utilizing diphtheria toxin fragment B as a carrier
    Patent number: 11219680
    Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Steptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Steptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: January 11, 2022
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: John E. MacNair, Michael A. Winters, Thomas Svab, Sheng-Ching Wang, William J. Smith, Cecilia Giovarelli
  • POLYSACCHARIDE-PROTEIN CONJUGATES UTILIZING DIPHTHERIA TOXIN FRAGMENT B AS A CARRIER
    Publication number: 20200061179
    Abstract: The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which polysaccharides obtained from bacterial capsules are conjugated to diphtheria toxin fragment B (DTFB) or a variant thereof. The immunogenic compositions may be multivalent pneumococcal polysaccharide conjugate compositions in which polysaccharides from one or more Streptococcus pneumoniae serotypes are conjugated to diphtheria toxin fragment B (DTFB) and, optionally, additional polysaccharides from one or more different Streptococcus pneumoniae serotypes are conjugated to one or more other carrier proteins.
    Type: Application
    Filed: February 20, 2018
    Publication date: February 27, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: John E. MacNair, Michael A. Winters, Thomas Svab, Sheng-Ching Wang, William J. Smith, Cecilia Giovarelli
  • METHODS OF PURIFICATION OF NATIVE OR MUTANT FORMS OF DIPHTHERIA TOXIN
    Publication number: 20140193876
    Abstract: The present invention relates to the use of hydroxyapatite chromatography and multimodal chromatography, for punfication of diphtheria toxin, or a mutant form thereof, from a mixture, for example, a host cell fermentation mixture containing impurities such as host cell proteins and DNA. This invention further relates to the integration of such a method into a multi-step procedure with other fractionation methods for purification of diphtheria toxin suitable for in vitro and in vivo applications.
    Type: Application
    Filed: June 8, 2012
    Publication date: July 10, 2014
    Inventors: Aaron R. Goerke, Thomas Svab, Patrick McHugh, Kristin Valente