Patents by Inventor Thomas Sweet

Thomas Sweet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR INCREASING PROTEIN EXPRESSION AND/OR TREATING A HAPLOINSUFFICIENCY DISORDER
    Publication number: 20260009041
    Abstract: A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon.
    Type: Application
    Filed: April 22, 2025
    Publication date: January 8, 2026
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • Methods and compositions for increasing protein expression and/or treating a haploinsufficiency disorder
    Patent number: 12281314
    Abstract: A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: April 22, 2025
    Assignees: CASE WESTERN RESERVE UNIVERSITY, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • METHODS AND COMPOSITIONS FOR TREATING A PREMATURE STOP CODON-MEDIATED DISORDER
    Publication number: 20240050594
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Application
    Filed: April 3, 2023
    Publication date: February 15, 2024
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • Methods and compositions for treating a premature stop codon-mediated disorder
    Patent number: 11617802
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Grant
    Filed: January 16, 2021
    Date of Patent: April 4, 2023
    Assignees: CASE WESTERN RESERVE UNIVERSITY, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • METHODS AND COMPOSITIONS FOR INCREASING PROTEIN EXPRESSION AND/OR TREATING A HAPLOINSUFFICIENCY DISORDER
    Publication number: 20220073933
    Abstract: A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon.
    Type: Application
    Filed: September 26, 2019
    Publication date: March 10, 2022
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • METHODS AND COMPOSITIONS FOR TREATING A PREMATURE STOP CODON-MEDIATED DISORDER
    Publication number: 20210299279
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Application
    Filed: January 16, 2021
    Publication date: September 30, 2021
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • Methods and compositions for treating a premature stop codon-mediated disorder
    Patent number: 10905778
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: February 2, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jeffery M. Coller, Thomas Sweet
  • METHODS AND COMPOSITIONS FOR TREATING A PREMATURE STOP CODON-MEDIATED DISORDER
    Publication number: 20200101174
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Application
    Filed: October 28, 2019
    Publication date: April 2, 2020
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • Pump assembly with sound emitting device
    Publication number: 20090032549
    Abstract: A container for a liquid is provided with a pressurizing pump sprayer that includes a sound emitting device. The sound emitting device emits a sound in response to pressure on a plate of the pressurizing pump sprayer.
    Type: Application
    Filed: July 30, 2007
    Publication date: February 5, 2009
    Inventors: Christopher G. Rowen, Thomas Sweet
  • Method, apparatus and article for validating ADC devices, such as barcode, RFID and magnetic stripe readers
    Publication number: 20050274801
    Abstract: Reconfiguration and/or upgrade of Automatic Data Collection (ADC) devices such as barcode readers, RFID readers and/or magnetic stripe readers is facilitated by performing adequate testing, prompt accurate analysis of the results of such testing, and prompt delivery of the analysis to those involved with the development of ADC device builds, associated components and/or functionality. The functionality of ADC devices and/or ADC device platforms is determined and appropriate tests are selected and provided to the ADC device and/or ADC device platform for execution. Results are received, analyzed and provided to appropriate users.
    Type: Application
    Filed: May 17, 2005
    Publication date: December 15, 2005
    Applicant: Intermec IP Corp.
    Inventors: Andrew Harding, Jeffrey Hunt, Thomas Sweet