Patents by Inventor Thomas T. Howarth
Thomas T. Howarth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6048977Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.Type: GrantFiled: April 6, 1995Date of Patent: April 11, 2000Assignee: SmithKline Beecham p.l.c.Inventors: Martin Cole, Thomas T Howarth, Christopher Reading
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Patent number: 6031093Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.Type: GrantFiled: April 6, 1995Date of Patent: February 29, 2000Assignee: SmithKline Beecham p.l.c.Inventors: Martin Cole, Thomas T Howarth, Christopher Reading
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Patent number: 4684641Abstract: 7.alpha.-Hydroxyamino-7.beta.-[2-substituted-2-(acylamino)acetamido]-cephal osporin antibiotics, pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, a method of treating susceptible infections therewith, and intermediates therefor.Type: GrantFiled: June 27, 1985Date of Patent: August 4, 1987Assignee: Pfizer Inc.Inventors: Colin W. Greengrass, David W. T. Hoople, Thomas T. Howarth
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Patent number: 4684642Abstract: 7.alpha.-Hydroxyamino-7.beta.-[2-substituted-2-(acylamino)acetamido]cephalo sporin antibiotics, pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, a method of treating susceptible infections therewith, and intermediates therefor.Type: GrantFiled: March 5, 1986Date of Patent: August 4, 1987Assignee: Pfizer Inc.Inventors: Colin W. Greengrass, David W. T. Hoople, Thomas T. Howarth
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Patent number: 4609495Abstract: The compounds of the formula (II): ##STR1## and salts and esters thereof wherein R is an inert organic group of up to 18 carbon atoms and are able to inhibit the action of various bacterial .beta.-lactamases. Thus when a compound of the formula (II) or its salt or ester is used together with a penicillin or cephalosporin, the effectiveness of that penicillin or cephalosporin can be considerably enhanced. These novel synergysts can be prepared by etherification of an ester of clavulanic acid followed if desired by deesterification. The novel synergysts also possess antibacterial activity.Type: GrantFiled: June 29, 1981Date of Patent: September 2, 1986Assignee: Beecham Group p.l.c.Inventors: Roger J. Ponsford, Thomas T. Howarth
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Patent number: 4571392Abstract: The present invention provides the compounds of the formula (II): ##STR1## and salts and esters thereof wherein R.sub.1 is a hydrogen atom or an alkyl group of 1-4 carbon atoms and R.sub.2 is a hydrogen atom or an alkyl group of 1-4 carbon atoms or is joined to R.sub.1 to form part of a 5-, 6- or 7 membered carbocyclic ring. These compounds are .beta.-lactamase inhibitors able to enhance the effectiveness of pencillins and cephalosporins. Their preparation and compositions containing them are described.Type: GrantFiled: April 20, 1982Date of Patent: February 18, 1986Assignee: Beecham Group LimitedInventors: Thomas T. Howarth, King Luk
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Patent number: 4560552Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta. lactam antibiotics against many .beta.-lactamase producing bacteria.Type: GrantFiled: December 14, 1981Date of Patent: December 24, 1985Assignee: Beecham Group p.l.c.Inventors: Martin Cole, Thomas T. Howarth, Christopher Reading
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Patent number: 4556559Abstract: A new antibacterially active agent has been isolated from Streptomyces clvuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.Type: GrantFiled: July 13, 1978Date of Patent: December 3, 1985Assignee: Beecham Group p.l.c.Inventors: Martin Cole, Thomas T. Howarth, Christopher Reading
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Patent number: 4548815Abstract: The compounds of the formula (II): ##STR1## and salts and esters thereof wherein R is an inert ogranic group of up to 18 carbon atoms and are able to inhibit the action of various bacterial .beta.-lactamases. Thus when a compound of the formula (II) or its salt or ester is used together with a penicillin or cephalosporin, the effectiveness of that penicillin or cephalosporin can be considerably enhanced. These novel synergysts can be prepared by etherification of an ester of clavulanic acid followed if desired by deesterification. The novel synergysts also possess antibacterial activity.Type: GrantFiled: October 3, 1983Date of Patent: October 22, 1985Assignee: Beecham Group p.l.c.Inventors: Roger J. Ponsford, Thomas T. Howarth
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Patent number: 4529720Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulonic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potancy, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta. lactam antibiotics against many .beta.-lactamase producing bacteria.Type: GrantFiled: September 24, 1981Date of Patent: July 16, 1985Assignee: Beecham Group, p.l.c.Inventors: Martin Cole, Thomas T. Howarth, Christopher Reading
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Patent number: 4526783Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.Type: GrantFiled: June 9, 1981Date of Patent: July 2, 1985Assignee: Beecham Group p.l.c.Inventors: Martin Cole, Thomas T. Howarth, Christopher Reading
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Patent number: 4525352Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta. lactam antibotics against many .beta.-lactamase producing bacteria.Type: GrantFiled: December 3, 1981Date of Patent: June 25, 1985Assignee: Beecham Group p.l.c.Inventors: Martin Cole, Thomas T. Howarth, Christopher Reading
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Patent number: 4525353Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.Type: GrantFiled: February 26, 1982Date of Patent: June 25, 1985Assignee: Beecham Group p.l.c.Inventors: Martin Cole, Thomas T. Howarth, Christopher Reading
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Patent number: 4438101Abstract: The compounds of the formula (II): ##STR1## and salts and esters thereof wherein R.sub.1 is an inert organic group of up to 14 carbon atoms and R.sub.2 is an inert organic group of up to 16 carbon atoms, the group NR.sub.1 R.sub.2 containing up to 22 carbon atoms, are antibacterial agents able to enhance the effectiveness of penicillins and cephalosporins against certain .beta.-lactamase producing bacteria.Type: GrantFiled: September 22, 1978Date of Patent: March 20, 1984Assignee: Beecham Group LimitedInventors: Roger J. Ponsford, Thomas T. Howarth
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Patent number: 4428937Abstract: The compounds of the formula: ##STR1## and salts and esters thereof are useful agents for the treatment of bacterial infections either alone or in combination with a penicillin or cephalosporin derivative. The preceding compounds may be prepared by the hydrogenation of a compound of the formula: ##STR2## wherein R is a hydrogen atom or an acyl group or a salt or ester thereof.Type: GrantFiled: December 15, 1980Date of Patent: January 31, 1984Assignee: Beecham Group LimitedInventor: Thomas T. Howarth
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Patent number: 4427690Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria.Type: GrantFiled: September 24, 1976Date of Patent: January 24, 1984Assignee: Beecham Group LimitedInventors: Martin Cole, Thomas T. Howarth, Christopher Reading
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Patent number: 4426377Abstract: This invention provides the compounds of the formula (II): ##STR1## and salts and esters thereof, wherein R.sub.1 is H and R.sub.3 is H or an aryl, aralkyl, lower alkyl or substituted lower alkyl group or R.sub.1 and R.sub.3 are joined so that the CHR.sub.1.NH.CO.R.sub.3 moiety forms a group of the sub-formula (a): ##STR2## wherein R.sub.4 is a hydrogen atom or a NH.CO.R.sub.5 group wherein R.sub.5 is a lower alkyl, lower alkoxy lower alkyl, aryl, aralkyl, aryloxyalkyl, lower alkoxy or aryloxy group.The compounds have .beta.-lactamase inhibitory and anti-bacterial properties.The invention also provides a process for their preparation, and pharmaceutical compositions containing them.Type: GrantFiled: April 11, 1980Date of Patent: January 17, 1984Assignee: Beecham Group LimitedInventor: Thomas T. Howarth
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Patent number: 4382084Abstract: The compounds of the formula (II): ##STR1## and salts and esters theereof wherein R.sub.1 is an inert organic group of up to 14 carbon atoms and R.sub.2 is an inert organic group of up to 16 carbon atoms, the group NR.sub.1 R.sub.2 containing up to 22 carbon atoms, are antibacterial agents able to enhance the effectiveness of penicillins and cephalosporins against certain .beta.-lactamase producing bacteria.Type: GrantFiled: March 10, 1980Date of Patent: May 3, 1983Assignee: Beecham Group LimitedInventors: Roger J. Ponsford, Thomas T. Howarth
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Patent number: 4372946Abstract: Compounds of the formula (I): ##STR1## and salts and esters thereof, wherein R.sub.1 is a hydrogen atom or a lower alkyl, aryl or aralkyl group, R.sub.2 and R.sub.3 are independently hydrogen, aryl, aralkyl, lower alkyl or substituted lower alkyl, or R.sub.3 is joined to R.sub.1 to form a 4-, 5-, or 6- membered ring or is joined to R.sub.2 to form a 5- or 6- membered ring with the proviso that when R.sub.2 is hydrogen, R.sub.1 is not hydrogen and R.sub.1 and R.sub.3 are not joined to form a group of the sub-formula (a) wherein R.sub.4 is a hydrogen atom or a NH.CO.R.sub.5 group wherein R.sub.5 is a lower alkyl, lower alkoxy lower alkyl, aryl, aralkyl, aryloxyalkyl; lower alkoxy or aryloxy group have .beta.-lactamase inhibitory and anti-bacterial properties.Type: GrantFiled: July 9, 1980Date of Patent: February 8, 1983Assignee: Beecham Group LimitedInventors: Thomas T. Howarth, Eric Hunt
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Patent number: 4297345Abstract: The compounds of the formula: ##STR1## and salts and esters thereof are useful agents for the treatment of bacterial infections either alone or in combination with a penicillin or cephalosporin derivative. The preceding compounds may be prepared by the hydrogenation of a compound of the formula: ##STR2## wherein R is a hydrogen atom or an acyl group or a salt or ester thereof.Type: GrantFiled: October 22, 1979Date of Patent: October 27, 1981Assignee: Beecham Group LimitedInventor: Thomas T. Howarth