Abstract: Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.

Abstract: A chatter resistant shuttle valve is provided to direct fluid flow from at least two sources of pressurized fluid to a downstream apparatus. The shuttle valve includes a valve body with a shuttle valve member movably mounted inside. A dampening chamber is provided which dampen opening movement of the shuttle as it moved from a closed position on one side of the shuttle toward a closed position on the other end of the shuttle. One or more dampening chambers may be provided.

Abstract: Various sulfonamide-based compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.

Abstract: Various thienopyrimidine-based analog compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.

Abstract: A chatter resistant shuttle valve is provided to direct fluid flow from at least two sources of pressurized fluid to a downstream apparatus. The shuttle valve includes a valve body with a shuttle valve member movably mounted inside. A dampening chamber is provided which dampen opening movement of the shuttle as it moved from a closed position on one side of the shuttle toward a closed position on the other end of the shuttle. One or more dampening chambers may be provided.

Abstract: A fluid flow control valve that may be used as both a check valve and a relief valve. The valve includes a moveable valve member having a surface capable of forming two or more valve seal areas with two or more valve seat surfaces on a valve seat member. The valve seat surfaces may be formed by coining a portion of valve seat surfaces on fingers of the valve seat member. One of the valve seat fingers in inclined from the outlet toward the inlet. The valve seat member is metal, forming a metal to metal valve seat arrangement with the valve seat member.