Patents by Inventor Thomas Thurnherr

Thomas Thurnherr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Determination of single peak melting temperature by PCR analogy and double sigmoid equation
    Patent number: 8265879
    Abstract: Systems and methods for determining melting temperatures, Tm, for DNA from melt curve data. The systems and methods also allow for quantitative determination of gene amount based on peak height. A PCR analogy is used to perform quantization of an acquired melting curve dataset. The melting curve is transformed using a horizontal flip and a horizontal translation, and a double sigmoid equation is then fit to the data. Inverse translation and inverse horizontal flip transforms are applied to the equation to produce an equation based solution of the melt curve dataset. The equation based solution of the melt curve is then used to determine the first derivative (e.g., Tm value) and peak height.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: September 11, 2012
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Ronald T. Kurnik, Thomas Thurnherr
  • DETERMINATION OF SINGLE PEAK MELTING TEMPERATURE BY PCR ANALOGY AND DOUBLE SIGMOID EQUATION
    Publication number: 20100268472
    Abstract: Systems and methods for determining melting temperatures, Tm, for DNA from melt curve data. The systems and methods also allow for quantitative determination of gene amount based on peak height. A PCR analogy is used to perform quantization of an acquired melting curve dataset. The melting curve is transformed using a horizontal flip and a horizontal translation, and a double sigmoid equation is then fit to the data. Inverse translation and inverse horizontal flip transforms are applied to the equation to produce an equation based solution of the melt curve dataset. The equation based solution of the melt curve is then used to determine the first derivative (e.g., Tm value) and peak height.
    Type: Application
    Filed: April 17, 2009
    Publication date: October 21, 2010
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Ronald T. KURNIK, Thomas THURNHERR