Abstract: The present invention relates to a method of marking a petroleum hydrocarbon by adding to and uniformly mixing with said petroleum hydrocarbon a chemical marker of general formula (I) wherein two of the residues R1-R10 are independently of each other selected from C1-C4-alkoxy, and eight of the residues R1-R10 are independently of each other selected from the group consisting of hydrogen and C1-C4-alkyl, as well as to a composition of a petroleum hydrocarbon comprising a petroleum hydrocarbon and at least one chemical marker of general formula (I). The presence and concentration of the chemical marker of general formula (I) in the composition of the petroleum hydrocarbon can be advantageously determined by laser ionization coupled with mass spectrometry or by laser ionization coupled with ion mobility spectrometry.

Abstract: The present invention relates to a method of marking a petroleum hydrocarbon by adding to and uniformly mixing with said petroleum hydrocarbon a chemical marker of general formula (I) wherein two of the residues R1-R10 are independently of each other selected from C1-C4-alkoxy, and eight of the residues R1-R10 are independently of each other selected from the group consisting of hydrogen and C1-C4-alkyl, as well as to a composition of a petroleum hydrocarbon comprising a petroleum hydrocarbon and at least one chemical marker of general formula (I). The presence and concentration of the chemical marker of general formula (I) in the composition of the petroleum hydrocarbon can be advantageously determined by laser ionization coupled with mass spectrometry or by laser ionization coupled with ion mobility spectrometry.

Abstract: The present invention provides synthetic canine antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries.

Abstract: The present invention provides synthetic canine antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries.

Abstract: The present invention provides a method for determining the authenticity of a petroleum hydrocarbon allegedly comprising at least one specific chemical marker, as well as a method for determining adulteration of a petroleum hydrocarbon marked with at least one specific chemical marker. The methods claimed and described herein rely upon the use of specific chemical markers in combination with laser ionization at a wavelength of between about 300 nm and about 370 nm coupled with ion mobility spectrometry or with mass spectrometry.

Abstract: The present invention relates to a method of marking a petroleum hydrocarbon by adding to and uniformly mixing with said petroleum hydrocarbon a chemical marker of general formula (I) wherein two of the residues R1-R10 are independently of each other selected from C1-C4-alkoxy, and eight of the residues R1-R10 are independently of each other selected from the group consisting of hydrogen and C1-C4-alkyl, as well as to a composition of a petroleum hydrocarbon comprising a petroleum hydrocarbon and at is least one chemical marker of general formula (I). The presence and concentration of the chemical marker of general formula (I) in the composition of the petroleum hydrocarbon can be advantageously determined by laser ionization coupled with mass spectrometry or by laser ionization coupled with ion mobility spectrometry.

Abstract: The present disclosure provides humanized antibodies that specifically bind to CD3 with an optimized affinity and induce T cell-mediated killing of tumour related target antigen high expressing cells with high potency but have limited killing activity on target antigen low expressing cells. The present disclosure also provides bispecific antibodies comprising a first antigen-binding domain that specifically binds to human CD3 with optimized affinity and a second antigen-binding molecule that specifically binds a tumor-related antigen. The disclosure further relates to methods of generating such humanized antibodies and bispecific antibodies for biological, diagnostic, pharmaceutical and other uses.

Abstract: The present invention provides synthetic canine antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries.

Abstract: The present invention provides synthetic canine antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries.

Abstract: The present disclosure provides humanized antibodies that specifically bind to CD3 with an optimized affinity and induce T cell-mediated killing of tumour related target antigen high expressing cells with high potency but have limited killing activity on target antigen low expressing cells. The present disclosure also provides bispecific antibodies comprising a first antigen-binding domain that specifically binds to human CD3 with optimized affinity and a second antigen-binding molecule that specifically binds a tumor-related antigen. The disclosure further relates to methods of generating such humanized antibodies and bispecific antibodies for biological, diagnostic, pharmaceutical and other uses.

Abstract: The present invention provides synthetic canine antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries.

Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.

Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.

Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.

Abstract: The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties relevant to developability, wherein the collections may be used to select against any antigen using, for example, phage display.

Abstract: The present invention relates to a marking of polymeric liquid crystal material having determined optical characteristics allowing its authentication and reading by a machine and its authentication by the human eye. The marking is applied onto an item, good or article by a variable information printing process. The marking is in the form of indicia representing a unique code which allows for an easy authentication by the human eye and a secure tracking and tracing of the marked item, good or article throughout is life cycle.

Abstract: A method of increasing the solubility and/or dispersibility of a perylene dye in a liquid medium. The method comprises binding the perylene dye to a polymer which is soluble in the liquid medium. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

Abstract: Coding flake or film including at least two chiral liquid crystal polymer (CLCP) layers with a first CLCP layer that has a first detectable parameter and a second CLCP layer including a second detectable parameter; at least one additional layer including a third detectable parameter, the at least one additional layer comprising a material that is not a chiral liquid crystal polymer; and wherein at least the third detectable parameter is different from each of the first detectable parameter and the second detectable parameter.

Abstract: Method for increasing at least one of the solubility and dispersibility of a quaterrylene and/or terrylene dye in a liquid medium, including binding the quaterrylene or terrylene dye to a polymer which is soluble in the liquid medium. Various aspects relate without limitation to polymer-bonded quaterrylene or terrylene dyes, processes, markings, security features, articles and dye-doped polymers.

Abstract: The present invention relates to a marking on an item or substrate, which marking is based on a chiral nematic (also called cholesteric) liquid crystal precursor composition. Prior to curing the chiral liquid crystal precursor composition in the chiral liquid crystal state at least one optical property exhibited by the composition is modified by two modifying agents of different types in at least one area of the item or substrate.