Abstract: A vehicle, electric machine, and method of manufacturing an electric machine include a stator having teeth extending from a yoke portion toward a rotor and defining slots between adjacent teeth with windings positioned within the slots, wherein the slots are coated with an electrically insulating material having an arcuate surface exiting the slots and extending at least partially over the teeth on at least one end face of the stator to form a winding guide for bending/positioning the windings. The winding guide may be formed by a molded epoxy that replaces insulating paper slot liners while providing a template for forming the hairpin bends of end windings.

Abstract: A surgical implant includes a tray extending from a first end to a second end along a first plane, the tray including an upper surface and a lower surface, a first post coupled to and extending from the tray away from the first plane and configured to be inserted into a bone portion, the first post including a first opening extending through the first post, a second post coupled to and extending from the tray away from the first plane and configured to be implanted into the bone portion, the second post including a second opening extending through the second post, and a fastener removably coupled to the first post and the second post, the fastener extending from a first fastener end to a second fastener end through the first opening and the second opening.

Abstract: A hydraulic cylinder may include a housing and a rod extending from a working end positioned outside the housing through a rod end of the housing to a piston end positioned within the housing. The hydraulic cylinder may also include a piston arranged on the piston end of the rod and configured to articulate within the housing. The hydraulic cylinder may also include a cap end secured to the housing and having a pocket for receiving a sensor. The pocket may have a cylindrical sidewall. The cap end may include a bore extending therethrough and arranged generally tangential to the sidewall where the bore extends into the cap end, breaches the sidewall, and extends further passed the pocket. The hydraulic cylinder may also include a retention pin configured for placement in the bore and for an interference fit with the sensor when the sensor is arranged in the pocket.

Abstract: In examples, a semiconductor package comprises a first driver die adapted to be coupled to a high-side switch of a power supply, the first driver die adapted to drive a gate of the high-side switch. The package also includes a second driver die adapted to be coupled to a low-side switch of the power supply, the second driver die adapted to drive a gate of the low-side switch. The package also includes a controller die positioned between the first and second driver dies and configured to control the first and second driver dies. The package also includes a pair of bond wires configured to provide a differential signal between the controller die and the first driver die, a vertical plane of a bond wire in the pair of bond wires and a vertical plane of a side surface of the first driver die having an angle therebetween ranging from 80 to 95 degrees.

Abstract: Systems and methods are provided for creating and sharing knowledge among design houses. In particular, examples of the presently disclosed technology leverage the concepts of meta-optimizing and collaborative learning to reduce the computational burden shouldered by individual design houses using inverse design techniques to find optimal designs in a manner which protects intellectual property sensitive information. Examples may share versions of a central meta-optimizer (i.e. local meta-optimizers) among design houses targeting different (but related) design tasks. A local meta-optimizer can be trained to indirectly optimize a design task by computing hyper-parameters for a design house's private optimization function. The private optimization function may be using inverse design techniques to find an optimal design for a design task. This may correspond to finding a global minimum of a cost function using gradient descent techniques or more advanced global optimization techniques.

Abstract: A method of processing a video sequence is proposed, which comprises, for a video encoding tool of a set of video encoding tools configured for encoding the video sequence comprised in a video encoder, determining an efficiency value based on an encoding performance value and an encoding computational complexity value of the video encoding tool for encoding the video sequence, and determining, based on the efficiency value of the video encoding tool, whether to configure the video encoder to use the video encoding tool for the encoding of the video sequence.

Abstract: The present invention provides a compound of Formula (I) wherein R is (II) or (III), or a pharmaceutically acceptable salt thereof, useful for treating psoriasis, systemic lupus erythematosus, or type 1 diabetes.

Abstract: Reinforced surgical constructs and methods of tissue repairs. A surgical construct can offer both repair and shuttling capabilities to allow for a single pass to load multiple sutures at once. A surgical construct includes one or more repair sutures provided with one or more junctions (one or more releasable stitches), to allow the repair sutures to be joined and subsequently released. At least one of the one or more junctions (releasable stitches) can be formed by weaving back and forth another flexible strand (releasing suture) through the one or more repair sutures. When the flexible strand is pulled, it pulls out the one or more junctions (releasable stitches) from the repair sutures, freeing the repair sutures. The surgical construct may be part of a knotless or knotted construct.

Abstract: A processing system for processing a flexible substrate is described. The processing system includes a vacuum chamber having a wall with an opening for the flexible substrate, a substrate support for supporting the flexible substrate during transportation of the flexible substrate through the opening, and a measurement assembly for measuring at least one of a property of the flexible substrate and a property of one or more coatings on the flexible substrate. The measurement assembly and the substrate support are attached to the wall.

Abstract: An embodiment may respond to different weather profiles and market conditions within a controlled environment agricultural system, which may include one or more power consuming and environment controlling systems. Different market demands and prices may be used to influence which plants are grown and when they should be harvested. The growing process may be altered based on market demand, which may call for a varietal to be harvested at a delayed time or may require some other parameters to be optimized. A control unit may identify criticality of and power consumption by the systems and may compare those with the current cost of power. The control unit may analyze the cost of adjusting power to systems and the cost of powering those systems during a specified period of time. A weather profile may be forecasted which can be used to identify which systems to power or when to store energy.

Abstract: The disclosure provides a composition configured for oral use, the composition including at least one filler, water, a basic amine, and an organic acid, an alkali metal salt of an organic acid, or a combination thereof, wherein the organic acid has a logP value of from about 1 to about 12. At least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof. The association is in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or a combination of both. The organic acid is a monoester of a dicarboxylic acid or is a carotenoid derivative having one or more carboxylic acids.

Abstract: An apparatus for cryostorage and manipulation of a plurality of container units includes a cryochamber having a cryo-access port. The cryochamber is electrically cooled at cryogenic temperatures. A unit holder is located inside the cryochamber and is configured to hold a plurality of container units. A user access area is provided for selectively permitting access to a chosen container unit by an authenticated user who has been authenticated by the apparatus. A motive grasper is provided for selectively removing the chosen container unit from the cryochamber through the cryo-access port, and selectively placing the chosen container unit into the user access area.

Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD4OL) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.

Abstract: The present disclosure provides a system for using an in-line processing device with an apheresis device. The system includes a pressure system that includes a container configured to receive cells collected using the apheresis device and is configured to change a pressure of the container so as to direct the cells collected using the apheresis device to the in-line processing device.

Abstract: An apparatus includes a body and a head. The head defines a fluid reservoir. The head includes a distal face and a needle. The distal face is configured to engage an exterior surface of a patient's eye at an anterior region of the patient's eye. The needle is configured to extend distally from the distal face. The needle has a length sufficient to extend through a sclera layer of the patient's eye and thereby position at least a portion of a distal tip of the needle in a suprachoroidal space of the patient's eye at an anterior region of the patient's eye. The needle is in fluid communication with the fluid reservoir such that the needle is operable to deliver fluid from the fluid reservoir into the suprachoroidal space of the patient's eye.

Abstract: A data processing apparatus is provided that includes communication circuitry to transmit an interconnect message to a root port using a physical address mapped to the root port. Translation circuitry encapsulates, within the interconnect message to the root port, a Peripheral Component Interconnect Express (PCIe) message to a destination, the PCIe message having routing information encoded as a PCIe bus number associated with the destination.

Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: One embodiment is directed to a system comprising a portable device executing a mobile application; and a rack controller without a display unit, the rack controller comprising a base unit. The base unit includes a processor configured to execute software that directs the processor to interact with the mobile application to show information and receive user input associated with the rack controller and at least one of rack and patching equipment installed in one or more racks even if there is not a display unit coupled to the base unit. In additional embodiments, a rack controller is configured to determine whether each rack controller interface is connected to another rack controller as a function of a respective sense signal developed by the termination circuit associated with said rack controller interface. Other embodiments are disclosed.

Abstract: The invention relates to a method for determining the ability of a molecule to modulate the activity of a G protein-coupled receptor (GPCR), said method comprising the following steps: a) introducing, into a first container:—a first membrane preparation bearing one or more GPCRs and one or more G protein(s),—a source of GDP or a source of GTP,—a first ligand of the alpha subunit of a G protein (Galpha protein) labelled with a first member of a pair of RET partners, and a second ligand of the Galpha protein labelled with a second member of the pair of RET partners, said ligands being able to specifically bind, either individually or in combination, to the empty Galpha protein or to the full Galpha protein; b) measuring the RET signal emitted in the first container; c) introducing (i) into a second container, the same reactants as in step a) and the molecule to be tested or (ii) into the first container, the molecule to be tested; d) measuring the RET signal emitted in the second container or in the first conta

Abstract: Disclosed is a building board construction that provides enhanced acoustical properties. In one possible embodiment, the board is a gypsum board with opposing facing sheets and an intermediate set gypsum core. An opened celled polymeric sheet is formed within the gypsum core and gives the resulting board enhanced sound absorption. In an alternative embodiment, individual pieces of polymeric foam are used in stead of the polymeric sheet. Also disclosed are various manufacturing methods whereby boards with enhanced acoustical properties can be formed in an continuous process. The various components of the present disclosure, and the manner in which they interrelate, are described in greater detail hereinafter.