Patents by Inventor Thomas Tuschl
Thomas Tuschl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7838661Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: GrantFiled: August 31, 2009Date of Patent: November 23, 2010Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas Tuschl, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Patent number: 7838662Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: GrantFiled: August 31, 2009Date of Patent: November 23, 2010Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas Tuschl, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Patent number: 7838663Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: GrantFiled: August 31, 2009Date of Patent: November 23, 2010Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas Tuschl, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Patent number: 7838664Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: GrantFiled: August 31, 2009Date of Patent: November 23, 2010Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas Tuschl, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Patent number: 7838660Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: GrantFiled: August 31, 2009Date of Patent: November 23, 2010Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas Tuschl, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Publication number: 20100292308Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: ApplicationFiled: January 23, 2009Publication date: November 18, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: THOMAS TUSCHL, MARIANA LAGOS-QUINTANA, WINFRIED LENDECKEL, JUTTA MEYER, REINHARD RAUHUT
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Publication number: 20100292456Abstract: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAI. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3? ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.Type: ApplicationFiled: June 4, 2010Publication date: November 18, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung Der Wissenschaften e.V.Inventors: Thomas TUSCHL, Sayda Mahgoub Elbashir, Winfried Lendeckel
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Publication number: 20100286246Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21 -nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: ApplicationFiled: May 7, 2010Publication date: November 11, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas TUSCHL, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Publication number: 20100286385Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.Type: ApplicationFiled: June 4, 2010Publication date: November 11, 2010Applicant: ROCKEFELLER UNIVERSITYInventors: Thomas Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
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Publication number: 20100286245Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21 -nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: ApplicationFiled: May 7, 2010Publication date: November 11, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas TUSCHL, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Publication number: 20100273255Abstract: The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a microRNA shown in SEQ ID NOs: 1-94; 281-374; 467-481; 497-522; or 549, except that up to thirty percent of the bases may be wobble bases, and up to 10% of the contiguous bases may be non-complementary. The invention further relates to modified single stranded microRNA molecules, isolated single stranded anti-microRNA molecules and isolated microRNP molecules. In another embodiment, the invention relates to a method for inhibiting microRNP activity in a cell.Type: ApplicationFiled: May 1, 2006Publication date: October 28, 2010Inventors: Thomas Tuschl, Pablo Landgraf
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Publication number: 20100233706Abstract: In one aspect, the invention relates to a method for fixing a short nucleic acid in a biological sample. In another aspect, the invention relates to a method for detecting a target short nucleic acid in a biological sample. The method includes contacting the biological sample with an aldehyde-containing fixative, and subsequently contacting the sample with a water-soluble carbodiimide. In a further aspect, the invention relates to a kit for fixing a short nucleic acid in a biological sample. The kit includes a support substrate for holding the sample; an aldehyde-containing fixative; and a water-soluble carbodiimide.Type: ApplicationFiled: March 10, 2010Publication date: September 16, 2010Applicant: THE ROCKEFELLER UNIVERSITYInventors: Thomas Tuschl, John Pena, Pavol Cekan
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Patent number: 7772389Abstract: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.Type: GrantFiled: February 11, 2005Date of Patent: August 10, 2010Assignee: Rockefeller UniversityInventors: Thomas Tuschl, Markus Landthaler, Gunter Meister, Sebastien Pfeffer
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Patent number: 7723510Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: GrantFiled: May 11, 2007Date of Patent: May 25, 2010Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas Tuschl, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Publication number: 20100113561Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: ApplicationFiled: August 31, 2009Publication date: May 6, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas Tuschl, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Publication number: 20100099748Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: ApplicationFiled: August 31, 2009Publication date: April 22, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas TUSCHL, Mariana LAGOS-QUINTANA, Winfried LENDECKEL, Jutta MEYER, Reinhard RAUHUT
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Publication number: 20100093837Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: ApplicationFiled: August 31, 2009Publication date: April 15, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas Tuschl, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Publication number: 20100087513Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: ApplicationFiled: August 31, 2009Publication date: April 8, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas TUSCHL, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Publication number: 20100087512Abstract: In Caenorhabditis elegans, lin-4 and let-7 enclode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as “small temporal RNAs” (stRNAs). We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, (miRNAs), exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRAN, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.Type: ApplicationFiled: August 31, 2009Publication date: April 8, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Thomas Tuschl, Mariana Lagos-Quintana, Winfried Lendeckel, Jutta Meyer, Reinhard Rauhut
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Publication number: 20100010207Abstract: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3? ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.Type: ApplicationFiled: August 7, 2009Publication date: January 14, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung Der Wissenschaften e.V.Inventors: Thomas Tuschl, Sayda Mahgoub Elbashir, Winfried Lendeckel