Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.

Abstract: A novel maize variety designated X18N926 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X18N926 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X18N926 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X18N926, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X18N926 are provided. Methods for producing maize varieties derived from maize variety X18N926 and methods of using maize variety X18N926 are disclosed.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes first and second gas permeable panes defining an evacuated gap in communication with a vacuum source; a first exterior pane spaced from the first gas permeable pane defining a first pressurized gap in communication with a source of pressurized gas; and a second exterior pane spaced from the second gas permeable pane defining a second pressurized gap in communication with the source of pressurized gas.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes first and second gas permeable panes defining an evacuated gap in communication with a vacuum source; a first exterior pane spaced from the first gas permeable pane defining a first pressurized gap in communication with a source of pressurized gas; and a second exterior pane spaced from the second gas permeable pane defining a second pressurized gap in communication with the source of pressurized gas.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes first and second gas permeable panes defining an evacuated gap in communication with a vacuum source; a first exterior pane spaced from the first gas permeable pane defining a first pressurized gap in communication with a source of pressurized gas; and a second exterior pane spaced from the second gas permeable pane defining a second pressurized gap in communication with the source of pressurized gas.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes first and second gas permeable panes defining an evacuated gap in communication with a vacuum source; a first exterior pane spaced from the first gas permeable pane defining a first pressurized gap in communication with a source of pressurized gas; and a second exterior pane spaced from the second gas permeable pane defining a second pressurized gap in communication with the source of pressurized gas.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes an interior pane and first and second exterior panes. The first exterior pane and a first side of the interior pane defines an evacuated gap in communication with a vacuum source and a second side of the interior pane and the second exterior pane defines a pressurized gap in communication with the source of pressurized gas.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes an interior pane and first and second exterior panes. The first exterior pane and a first side of the interior pane defines an evacuated gap in communication with a vacuum source and a second side of the interior pane and the second exterior pane defines a pressurized gap in communication with the source of pressurized gas.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes first and second gas permeable panes defining an evacuated gap in communication with a vacuum source; a first exterior pane spaced from the first gas permeable pane defining a first pressurized gap in communication with a source of pressurized gas; and a second exterior pane spaced from the second gas permeable pane defining a second pressurized gap in communication with the source of pressurized gas.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes first and second gas permeable panes defining an evacuated gap in communication with a vacuum source; a first exterior pane spaced from the first gas permeable pane defining a first pressurized gap in communication with a source of pressurized gas; and a second exterior pane spaced from the second gas permeable pane defining a second pressurized gap in communication with the source of pressurized gas.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes an interior pane and first and second exterior panes. The first exterior pane and a first side of the interior pane defines an evacuated gap in communication with a vacuum source and a second side of the interior pane and the second exterior pane defines a pressurized gap in communication with the source of pressurized gas.

Abstract: A dynamic multi-pane insulating assembly and system including methods for dynamically maintaining the thermal resistance value of the assembly and system. The dynamic multi-pane insulating assembly and system includes first and second gas permeable panes defining an evacuated gap in communication with a vacuum source; a first exterior pane spaced from the first gas permeable pane defining a first pressurized gap in communication with a source of pressurized gas; and a second exterior pane spaced from the second gas permeable pane defining a second pressurized gap in communication with the source of pressurized gas.

Abstract: A computer-implemented method for replicating snapshots across backup domains may include 1) identifying a replication of a snapshot from a source storage device within a source domain to a target storage device within a target domain, 2) identifying a source master system within the source domain and a target master system within the target domain, 3) identifying metadata for managing the snapshot at the source master system, and 4) transmitting the metadata from the source master system to the target master system using a master-to-master communication channel that is separate from a communication channel used for the replication. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A LED luminaire track lighting system includes an elongate track, having a number of longitudinal guideways, for attachment to a support surface, as well as a number of current conductors arranged within at least some of the guideways. The first of these conductors are power conductors and the second conductors are data conductors, the conductors being electrically isolated from each other. The lighting system further contains a first adapter for connection to a source of electrical power for the power conductors, and a second adapter for connection to a source of control data for application of data to the data conductors. There is at least one LED color-changing luminaire present in the system, and this luminaire contains a number of LEDs, each of which, when energized, generates a single color out of a discrete plurality of colors. A data converter converts data along the data lines to control the currents in the individual groups of color LEDs so that they create a desired composite color.

Abstract: Color wheel for lighting fixture, which includes a polygonal metal plate, which has slotted metal bars seated on the side edge of the polygonal plate with rectangular glass plates, e.g. dichroic filters adhesively held in the slots of the metal bars spaced. The glass plates are not in direct contact with the metal bars and are spaced close to each other, but not in contact, in a peripheral array.

Abstract: To achieve priming during start-up and repriming during operation, a self-priming pump system is provided. The self-priming pump system includes a discharge priming reservoir for storing priming liquid for a pump. The discharge priming reservoir has an inlet in communication with the outlet of the pump for receiving priming liquid from the pump and has an outlet in communication with the pump upstream of an impeller and downstream of a liquid supply reservoir for supplying the priming liquid to the pump. The self-priming pump system is operable to separate air from priming liquid in the discharge priming reservoir during recirculation of priming liquid. In addition, a priming valve is disposed between the discharge priming reservoir and the pump to control circulation of priming liquid through the self-priming pump system.