Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

Abstract: The invention relates to a method and a system for providing fluids, comprising two components, wherein a first component is a container with at least one first reservoir for taking up a fluid and a second reservoir for ventilation of the system, wherein said first and second reservoir are sealed with a seal, and a second component which is a dock for taking up the container, wherein the dock comprises an inner bottom surface comprising first formations for fluid piercing of the container's at least one first reservoir for taking up a fluid and second formations for piercing of the container's second reservoir for ventilation, and wherein said inner bottom surface is a drain plate comprising a drain, wherein the container has fins on its outer edge which engage into two parallel arranged recesses at the inner side surface of the dock for fixing the container within the dock in a first position when the fins of the container engage in a first recess which is a storage snap fit or a second position when the fin

Abstract: A microfluidic flow controller comprising a substrate having formations defining two or more fluid channels having channel fluid ports which are open at an outer surface of the substrate; and a flexible layer having formations defining a fluid channel which, when the flexible layer is positioned over the substrate so as to cover at least the channel fluid ports, provides a fluid communication path between the channel fluid ports but which, when a force is applied to press the flexible layer towards the substrate, deforms so as to inhibit fluid communication between the channel fluid ports.

Abstract: A microfluidic device includes first and second outer layers each having one or more microfluidic formations and an intermediate layer bonded between the first and second outer layers; in which the glass transition temperature of the first outer layer is higher than the glass transition temperature of the second outer layer.

Abstract: A microfluidic flow controller comprising a substrate having formations defining two or more fluid channels having channel fluid ports which are open at an outer surface of the substrate; and a flexible layer having formations defining a fluid channel which, when the flexible layer is positioned over the substrate so as to cover at least the channel fluid ports, provides a fluid communication path between the channel fluid ports but which, when a force is applied to press the flexible layer towards the substrate, deforms so as to inhibit fluid communication between the channel fluid ports.

Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.