Abstract: A computational evidence platform extracts clinical concepts from medical evidence sources and creates a database of elemental diagnostic factors and elemental investigations links to medical conditions. Input from a person groups factors and investigations makes corrections and adds a ranking. Elemental factors and investigations do not include information specific to their associated conditions but include synonyms and a link to a medical ontology. A patient state is determined by extracting patient known diagnostic factors and investigation results from the patient chart. These known factors and results are matched to the database and a ranking of likely conditions are output. Next-best actions per condition are output by determining factors not yet known and investigations not yet performed. Next-best actions across conditions are determined by performing a recursive tree search of the database and assuming that unknown factors are now known to generate a score for each assumption.

Abstract: A computational evidence platform extracts clinical concepts from medical evidence sources and creates a database of elemental diagnostic factors and elemental investigations links to medical conditions. Input from a person groups factors and investigations makes corrections and adds a ranking. Elemental factors and investigations do not include information specific to their associated conditions but include synonyms and a link to a medical ontology. A patient state is determined by extracting patient known diagnostic factors and investigation results from the patient chart. These known factors and results are matched to the database and a ranking of likely conditions are output. Next-best actions per condition are output by determining factors not yet known and investigations not yet performed. Next-best actions across conditions are determined by performing a recursive tree search of the database and assuming that unknown factors are now known to generate a score for each assumption.

Abstract: A computational evidence platform extracts clinical concepts from medical evidence sources and creates a database of elemental diagnostic factors and elemental investigations links to medical conditions. Input from a person groups factors and investigations makes corrections and adds a ranking. Elemental factors and investigations do not include information specific to their associated conditions but include synonyms and a link to a medical ontology. A patient state is determined by extracting patient known diagnostic factors and investigation results from the patient chart. These known factors and results are matched to the database and a ranking of likely conditions are output. Next-best actions per condition are output by determining factors not yet known and investigations not yet performed. Next-best actions across conditions are determined by performing a recursive tree search of the database and assuming that unknown factors are now known to generate a score for each assumption.

Abstract: A retention system for a bearing member includes a sleeve member and a retention member. The retention system includes an inner shoulder adapted to limit movement of the bearing member in at least one of a first axial direction and a second axial direction relative to the bore. The retention system includes an outer shoulder adapted to limit movement of at least one of the sleeve member and the retention member in at least one of the first axial direction and the second axial direction relative to the bore. The retention system includes a plurality of fasteners adapted to limit movement of each of the sleeve member and the retention member in at least one of the first axial direction and the second axial direction relative to the bore. Each of the sleeve member and the retention member is adapted to limit contact of the bearing member with the bore.

Abstract: A retention system for a bearing member includes a sleeve member and a retention member. The retention system includes an inner shoulder adapted to limit movement of the bearing member in at least one of a first axial direction and a second axial direction relative to the bore. The retention system includes an outer shoulder adapted to limit movement of at least one of the sleeve member and the retention member in at least one of the first axial direction and the second axial direction relative to the bore. The retention system includes a plurality of fasteners adapted to limit movement of each of the sleeve member and the retention member in at least one of the first axial direction and the second axial direction relative to the bore. Each of the sleeve member and the retention member is adapted to limit contact of the bearing member with the bore.

Abstract: A rooftop cargo carrier having a rack that can be mounted on the roof of an automotive vehicle and on which a linear rail is disposed, along which linear rail a support structure for an object to be transported can be moved between a transport position, in which the support structure is disposed above the linear rail, and an intermediate position, in which the support structure is disposed on the side as an extension of the linear rail. The configuration comprising the linear rail and the support structure can be pivoted between the intermediate position and a loading position, in which the linear rail and the support structure are disposed at a blunt angle relative to the rack. The rooftop cargo carrier also includes a retainer that allows joint pivoting movement of the linear rail and the support structure relative to the rack only after the intermediate position has been reached.

Abstract: A rooftop cargo carrier having a rack that can be mounted on the roof of an automotive vehicle and on which a linear rail is disposed, along which linear rail a support structure for an object to be transported can be moved between a transport position, in which the support structure is disposed above the linear rail, and an intermediate position, in which the support structure is disposed on the side as an extension of the linear rail. The configuration comprising the linear rail and the support structure can be pivoted between the intermediate position and a loading position, in which the linear rail and the support structure are disposed at a blunt angle relative to the rack. The rooftop cargo carrier also includes a retainer that allows joint pivoting movement of the linear rail and the support structure relative to the rack only after the intermediate position has been reached.

Abstract: Shields or deflectors are supported on fuse barrels and positioned to protect power linemen and other electrical workers on high voltage distribution lines against injuries resulting from the ejection of sparks and fuse debris that occurs when a fuse melts or operates due to excessively high electrical currents, by securing the deflectors on the fuse barrels in a position immediately below the fuse barrels where the deflectors can effectively direct the dangerous materials away from the workers.

Abstract: There is provided a compound of formula I, wherein Y1, Y2, Y3, Y4, Z1, Z2, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, for use in the treatment of spinal cord injury.

Abstract: Shields or deflectors are supported on fuse barrels and positioned to protect power linemen and other electrical workers on high voltage distribution lines against injuries resulting from the ejection of sparks and fuse debris that occurs when a fuse melts or operates due to excessively high electrical currents, by securing the deflectors on the fuse barrels in a position immediately below the fuse barrels where the deflectors can effectively direct the dangerous materials away from the workers.

Abstract: There is provided a compound of formula I, wherein Y1, Y2, Y3, Y4, Z1, Z2, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, for use in the treatment of spinal cord injury.

Abstract: Shields or deflectors are supported on fuse barrels and positioned to protect power linemen and other electrical workers on high voltage distribution lines against injuries resulting from the ejection of sparks and fuse debris that occurs when a fuse melts or operates due to excessively high electrical currents, by securing the deflectors on the fuse barrels in a position immediately below the fuse barrels where the deflectors can effectively direct the dangerous materials away from the workers.

Abstract: There is provided a compound of formula I, wherein Y1, Y2, Y3, Y4, Z1, Z2, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, for use in the treatment of spinal cord injury.

Abstract: The present invention refers to the renin/prorenin receptor (RER) signal transduction pathway and, in particular, to the role of promyelocytic zinc finger protein (PLZF) and its downstream targets involved in this pathway, e.g. the p85? subunit of phosphatidylinositol-3 kinase (PI3K-p85?). In more detail, the present invention refers to a method for determination of RER activity, e.g. stimulation or inhibition of RER activity, using PLZF activity as a measurement from which RER activity is derived. For the determination of RER activity, use can be made of RER/PLZF protein interaction, PLZF translocation and/or PLZF recruitment. The present invention further refers to a use of said method for identifying RER ligands, e.g. pharmaceutically active agonists or antagonists, as well as for studying undesired side-effects of renin inhibitors.

Abstract: A duty cycle controller apparatus for producing a duty cycle signal for controlling switching of switches of a battery charger having an AC input for receiving power and an output for supplying power to charge a battery in response to switching of the switches, while maintaining a high power factor at the AC input. The duty cycle controller apparatus includes a current command signal generator having a plurality of signal inputs for receiving a plurality of signals representing a plurality of operating conditions of the charger, a plurality of current command outputs and a processor operably configured to generate a plurality of current command signals at the current command outputs in response to respective sets of operating conditions.